Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart

European Journal of Pharmacology

Volumn 530, Issue 3, 2006, Pages 243-249

  Létienne, Robert ^a   Vié, Bruno ^a   Le Grand, Bruno ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Heart rate regulation; Voltage gated sodium channel blocker

Indexed keywords

KC 12291; LIDOCAINE; N [1 [4 (4 FLUOROPHENOXY)BUTYL] 4 PIPERIDINYL] N METHYL 2 BENZOTHIAZOLAMINE; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART RATE; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SINUS NODE; SODIUM CURRENT;

ANIMALS; BENZOTHIAZOLES; BRADYCARDIA; HEART ATRIA; HEART RATE; LIDOCAINE; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; SINOATRIAL NODE; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; THIADIAZOLES; THIAZOLES;

EID: 30444451315     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.11.035     Document Type: Article

References (33)

1. S. Abraham, G.N. Beatch, B.A. MacLeod, and M.J. Walker Antiarrhythmic properties of tetrodotoxin against occlusion-induced arrhythmias in the rat: a novel approach to the study of the antiarrhythmic effects of ventricular sodium channel blockade J. Pharmacol. Exp. Ther. 251 1989 1166 1173
2. M. Baruscotti, D. DiFrancesco, and R.B. Robinson A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells J. Physiol. 492 1996 21 30
3. + current contribution to the diastolic depolarisation in newborn rabbit SA node cells Am. J. Physiol. 279 2000 H2303 H2309
4. D.W. Benson, D.W. Wang, M. Dyment, T.K. Knilans, F.A. Fish, M.J. Strieper, T.H. Rhodes, and A.L. Georges Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A) J. Clin. Invest. 112 2003 1019 1028
5. M.R. Boyett, H. Honjo, and I. Kodama The sino-atrial node, a heterogeneous pacemaker structure Cardiovasc. Res. 47 2000 658 687
6. H.S. Cho, M. Takano, and A. Noma The electrophysiological properties of spontaneously beating pacemaker cells isolated from mouse sinoatrial node J. Physiol. 550 2003 169 180
7. D. DiFrancesco Pacemaker mechanisms in cardiac tissue Annu. Rev. Physiol. 55 1993 455 472
8. H.J. Duff, R.S. Sheldon, and N.J. Cannon Tetrodotoxin: sodium channel specific anti-arrhythmic activity Cardiovasc. Res. 22 1988 800 807
9. J.S. Gillespie, and T.C. Muir A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat Br. J. Pharmacol. 30 1967 78 87
10. R.F. Gilmour, D.G. Morrical, P.J. Ertel, J.F. Maesaka, and D.P. Zipes Depressant effects of fast sodium channel blockade on the electrical activity of ischaemic canine ventricle: mediation by the sympathetic nervous system Cardiovasc. Res. 18 1984 405 413
11. M. Goethals, A. Raes, and P.P. Van Bogaert Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors Circulation 88 1993 2389 2401
12. H. Himmel, D. Wihelm, and U. Ravens Effects of R56865 on membrane currents in isolated ventricular cardiomyocytes of the guinea-pig Eur. J. Pharmacol. 187 1990 235 240
13. 2+ release from SR in cardiac myocytes Am. J. Physiol. 266 1994 H511 H520
14. G.W. John, and J.P. Valentin Analysis of the pulmonary hypertensive effects of the isoprostane derivative, 8-iso-PGF2alpha, in the rat Br. J. Pharmacol. 122 1997 899 905
15. G.W. John, R. Létienne, B. Le Grand, C. Pignier, B. Vacher, J.F. Patoiseau, F.C. Colpaert, and A. Coulombe KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties Cardiovasc. Drug Rev. 22 2004 17 26
16. Y.K. Ju, D.A. Saint, and P.W. Gage Effects of lignocaine and quinidine on the persistent sodium current in rat ventricular myocytes Br. J. Pharmacol. 107 1992 311 316
17. Y.K. Ju, D.A. Saint, G.D. Hirst, and P.W. Gage Sodium currents in toad cardiac pacemaker cells J. Membr. Biol. 145 1995 119 128
18. Y.K. Ju, P.W. Gage, and D.A. Saint Tetrodotoxin-sensitive inactivation-resistant sodium channels in pacemakers cells influence heart rate Pflügers Arch. 431 1996 868 875
19. + currents in pacemaker activity in the sinoatrial node Am. J. Physiol. 272 1997 H2793 H2806
20. B. Le Grand, A. Marty, S. Vieu, J.M. Talmant, and G.W. John Veratrine-induced tetanic contracture of the rat isolated left atrium. Evidence for novel direct protective effects of prazosin and WB4101 Naunyn-Schmiedeberg's Arch. Pharmacol. 348 1993 184 190
21. + current blockers Am. J. Physiol. 269 1995 H533 H540
22. B. Le Grand, A. Coulombe, and G.W. John Late sodium current inhibition in human isolated cardiomyocytes by R 56865 J. Cardiovasc. Pharmacol. 31 1998 800 804
23. R. Létienne, B. Vié, A. Puech, S. Vieu, B. Le Grand, and G.W. John Evidence that ranolazine behaves as a weak beta1 -and beta2-adrenoceptor antagonist in the rat cardiovascular system Naunyn-Schmiedeberg's Arch. Pharmacol. 363 2001 464 471
24. S.K. Maier, R.E. Westenbroek, T.T. Yamanushi, H. Dobrzynski, M.R. Boyett, W.A. Catterall, and T. Scheuer An unexpected requirement for brain-type sodium channels for control of heart rate in the mouse sinoatrial node Proc. Natl. Acad. Sci. U. S. A. 100 2003 3507 3512
25. T. Mitsuiye, Y. Shinagawa, and A. Noma Sustained inward current during pacemaker depolarization in mammalian sinoatrial node cells Circ. Res. 87 2000 88 91
26. + current in pacemaker cells isolated from rabbit sinoatrial node Am. J. Physiol. 270 1996 H2108 H2119
27. D. Nuyens, M. Stengl, S. Dugarmaa, T. Rossenbacker, V. Compernolle, Y. Rudy, J.F. Smits, W. Flameng, C.E. Clancy, L. Moons, M.A. Vos, M. Dewerchin, K. Benndorf, D. Collen, E. Carmeliet, and P. Carmeliet Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome Nat. Med. 7 2001 1021 1027
28. R.L. Rasmusson, J.W. Clark, W.R. Giles, E.F. Shibata, and D.L. Campbell A mathematical model of a bullfrog cardiac pacemaker cell Am. J. Physiol. 259 1990 H352 H369
29. S. Tamareille, B. Le Grand, G.W. John, D. Feuvray, and A. Coulombe Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels J. Cardiovasc. Pharmacol. 40 2002 346 355
30. J.C. Tomlinson, and T.N. James Pharmacologic actions of tetrodotoxin studied by direct perfusion of the sinus node Circ. Res. 23 1968 501 506
31. M.W. Veldkamp, R. Wilders, A. Baartscheer, J.G. Zegers, C.R. Bezzina, and A.A. Wilde Contribution of sodium channel mutations to bradycardia and sinus node dysfunction in LQT3 families Circ. Res. 92 2003 976 983
32. L. Ver Donck, M. Borgers, and F. Verdonck Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle Cardiovasc. Res. 27 1993 349 357
33. M. Yamamoto, H. Honjo, R. Niwa, and I. Kodama Low-frequency extracellular potentials recorded from the sinoatrial node Cardiovasc. Res. 39 1998 360 372