A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells

Journal of Physiology

Volumn 492, Issue 1, 1996, Pages 21-30

  Baruscotti, Mirko ^a   DiFrancesco, Dario ^b   Robinson, Richard B ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

TETRODOTOXIN;

ACTION POTENTIAL; AGING; ANIMAL CELL; ARTICLE; CELL AGING; CELL MATURATION; CONTROLLED STUDY; HYPERPOLARIZATION; ION CURRENT; NEWBORN; NONHUMAN; PACEMAKER NERVE CELL; PATCH CLAMP; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RABBIT; SINUS NODE; SODIUM CURRENT;

EID: 0029923331     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021285     Document Type: Article

References (28)

1. ALMERS, W. & MCCLESKEY, E. W. (1984). Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. Journal of Physiology 353, 585-608.
2. BARRY, P. H. & LYNCH, J. W. (1991). Liquid junction potentials and small cell effects in patch clamp analysis. Journal of Membrane Biology 121, 101-117.
3. BELARDINELLI, L., GILES, W. R. & WEST, A. (1988). Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heart. Journal of Physiology 405, 615-633.
4. + channels. Biophysical Journal 69, 873-882.
5. DENYER, J. C. & BROWN, H. F. (1990). Rabbit sino-atrial node cells: isolation and electrophysiological properties. Journal of Physiology 428, 405-424.
6. f) to generation of spontaneous activity in rabbit sino-atrial node myocytes. Journal of Physiology 434, 23-40.
7. f) in cells isolated from the rabbit sino-atrial node. Journal of Physiology 377, 61-88
8. FABIATO, A. (1988). Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands. Methods in Enzymology 157, 378-417.
9. GILES, W. R. & IMAIZUMI, Y. (1988). Comparison of potassium currents in rabbit atrial and ventricular cells. Journal of Physiology 405, 123-145.
10. GILES, W. R., VAN GINNEKEN, A. C. G. & SHIBATA, E. F. (1986). Ionic currents underlying cardiac pacemaker activity: a summary of voltage-clamp data from single cells. In Cardiac Muscle: the Regulation of Excitation and Contraction, ed. NATHAN, R. D., pp. 1-27. Academic Press, New York.
11. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. & SIGWORTH, F. J. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv 391, 85-100.
12. HILLE, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates Inc., Sunderland, MA, USA.
13. IRISAWA, H. (1987). Membrane currents in cardiac pacemaker tissue. Experientia 43, 1131-1135.
14. IRISAWA, H., BROWN, H. F. & GILES, W. (1993). Cardiac pacemaking in the sinoatrial node. Physiological Reviews 73, 197-227.
15. KREITNER, D. (1975). Evidence for the existence of a rapid sodium channel in the membrane of rabbit sinoatrial cells. Journal of Molecular and Cellular Cardiology 7, 655-662.
16. KREITNER, D. (1978). Effects of polarization and of inhibitors of ionic conductances on the action potentials of nodal and perinodal fibers in rabbit sinoatrial node. In The Sinus Node, ed. BONKE, F. I. M., pp. 270-278. Martinus Nijhoff Medical Division, The Hague.
17. KREITNER, D. (1985). Electrophysiological study of the two main pacemaker mechanisms in the rabbit sinus node. Cardiovascular Research 19, 304-318.
18. LENFANT, J., MIRONNEAU, J., GARGOUIL, Y. & GALAND, G. (1968). Analyse de l'activité électrique spontanée du centre de l'automatisme cardiaque de lapin par les inhibiteurs de permeabilités membranaires. Comptes Rendus Hebdomadaires des Sceances de l'Academie des Sciences D. 226, 901-904.
19. LIPSIUS, S. L. & VASSALLE, M. (1978). Dual excitatory channels in the sinus node. Journal of Molecular and Cellular Cardiology 10, 753-767.
20. MACFARLANE, P. W. & VEITCH LAWRIE, T. D. (1989). Comprehensive Electrocardiology: Theory and Practice in Health and Disease, vols 2 and 3. Pergamon Press, New York.
21. NATHAN, R. D. (1986). Two electrophysiologically distinct types of cultured pacemaker cells from rabbit sinoatrial node. American Journal of Physiology 250, H325-329.
22. NEHER, E. (1992). Correction for liquid junction potentials in patch clamp experiments. Methods in Enzymology 207, 123-131.
23. NOMA, A., NAKAYAMA, T., KURACHI, Y. & IRISAWA, H. (1984). Resting K conductances in pacemaker and non-pacemaker heart cells of the rabbit. Japanese Journal of Physiology 34, 245-254.
24. ONO, K., FOZZARD, H. A. & HANCK, D. A. (1993). Mechanism of c-AMP-dependent modulation of cardiac sodium channel current kinetics. Circulation Research 72, 807-815.
25. TODA, N. (1980). Age-related changes in the transmembrane potential of isolated sino-atrial nodes and atria. Cardiovascular Research 1, 58-63.
26. f in single cells from rabbit sino-atrial node. Journal of Physiology 434, 57-83.
27. YAMAGISHI, S. & SANO, T. (1966). Effect of tetrodotoxin on the pacemaker action potential of the sinus node. Proceedings of the Japanese Academy 42, 1194-1196.
28. ZHANG, J., ROBINSON, R. B. & SIEGELBAUM, S. A. (1992). Sympathetic neurons mediate developmental change in cardiac sodium channel gating through long-term neu neurotransmitter action. Neuron 9, 97-103.