Regional differences in the role of the Ca2+ and Na+ currents in pacemaker activity in the sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Kodama, I ^a   Nikmaram, M R ^b   Boyett, M R ^c   Suzuki, R ^a   Honjo, H ^a   Owen, J M ^c  

^a NAGOYA UNIVERSITY   (Japan)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Cardiac; Heart

Indexed keywords

CALCIUM ION; NIFEDIPINE; SODIUM ION; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; MICROELECTRODE; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; RABBIT; SINUS NODE; SODIUM CURRENT;

EID: 0030757415     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.272.6.h2793     Document Type: Article

References (18)

1. Baruscotti, M., D. DiFrancesco, and R. B. Robinson. A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells. J. Physiol. (Lond.) 492: 21-30, 1996.
2. Bleeker, W. K., A. J. C. Mackaay, M. Masson-Pevet, L. N. Bouman, and A. E. Becker. Functional and morphological organization of the rabbit sinus node. Circ. Res. 46: 11-22, 1980.
3. K) (Abstract). J. Physiol. (Lond.) 479: 68P, 1994.
4. Boyett, M. R., S. M. Harrison, N. C. Janvier, S. O. McMorn, J. M. Owen, and Z. Shui. A list of vertebrate cardiac ionic currents. Nomenclature, properties and cloned equivalents. Cardiovasc. Res. 32: 455-481, 1996.
5. Boyett, M. R., G. Hart, A. J. Levi, and A. Roberts. Effects of repetitive activity on developed force and intracellular sodium in isolated sheep and dog Purkinje fibres. J. Physiol. (Lond.) 388: 295-322, 1987.
6. Boyett, M. R., A. V. Holden, H. Zhang, I. Kodama, and R. Suzuki. Atrial modulation of sinoatrial pacemaker rate. Chaos, Solitons & Fractals 5: 425-438, 1995.
7. Boyett, M. R., I. Kodama, H. Honjo, A. Arai, R. Suzuki, and J. Toyama. Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial node. Cardiovasc. Res. 29: 867-878, 1995.
8. Brown, A. M., K. S. Lee, and T. Powell. Sodium current in single rat heart muscle cells. J. Physiol. (Lond.) 318: 479-500, 1981.
9. Denyer, J. C., and H. F. Brown. Rabbit sino-atrial node cells: isolation and electrophysiological properties. J. Physiol. (Lond.) 428: 405-424, 1990.
10. 2+ antagonists and agonists in rabbit cardiac myocytes. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H1737-H1742, 1991.
11. Guo, J., K. Ono, and A. Noma. A sustained inward current activated at the diastolic potential range in rabbit sino-atrial node cells. J. Physiol. (Lond.) 483: 1-13, 1995.
12. Honjo, H., and M. R. Boyett. Correlation between action potential parameters and the size of single sino-atrial node cells isolated from the rabbit heart (Abstract). J. Physiol. (Lond.) 452: 128P, 1992.
13. + current and the hyperpolarization-activated current in rabbit sinoatrial node cells depends on cell size (Abstract). J. Physiol. (Lond.) 491: 154P, 1995.
14. Honjo, H., I. Kodama, W.-J. Zang, and M. R. Boyett. Desensitization to acetylcholine in single sinoatrial node cells isolated from the rabbit heart. Am. J. Physiol. 263 (Heart Circ. Physiol. 32): H1779-H1789, 1992.
15. Irisawa, H., H. F. Brown, and W. Giles. Cardiac pacemaking in the sinoatrial node. Physiol. Rev. 73: 197-227, 1993.
16. Kirchhof, C. J. H. J., F. I. M. Bonke, M. A. Allessie, and W. J. E. P. Lammers. The influence of the atrial myocardium on impulse formation in the rabbit sinus node. Pflügers Arch. 410: 198-203, 1987.
17. Kodama, I., and M. R. Boyett. Regional differences in the electrical activity of the rabbit sinus node. Pflügers Arch. 404: 214-226, 1985.
18. Kreitner, D. Electrophysiological study of the two main pacemaker mechanisms in the rabbit sinus node. Cardiovasc. Res. 19: 304-318, 1985.