메뉴 건너뛰기




Volumn 25, Issue 1, 2006, Pages 70-79

Mae inhibits Pointed-P2 transcriptional activity by blocking its MAPK docking site

Author keywords

ETS family transcription factors; Mae; MAPK; Pnt P2; SAM domain; Transcriptional regulation

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MAE; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POINTED P2; TRANSCRIPTION FACTOR YAN; UNCLASSIFIED DRUG;

EID: 30444442307     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600924     Document Type: Article
Times cited : (36)

References (42)
  • 1
    • 0035902045 scopus 로고    scopus 로고
    • Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila
    • Baker DA, Mille-Baker B, Wainwright SM, Ish-Horowicz D, Dibb NJ (2001) Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Nature 411: 330-334
    • (2001) Nature , vol.411 , pp. 330-334
    • Baker, D.A.1    Mille-Baker, B.2    Wainwright, S.M.3    Ish-Horowicz, D.4    Dibb, N.J.5
  • 2
    • 0037954572 scopus 로고    scopus 로고
    • Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
    • Biondi RM, Nebreda AR (2003) Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J 372: 1-13
    • (2003) Biochem J , vol.372 , pp. 1-13
    • Biondi, R.M.1    Nebreda, A.R.2
  • 3
    • 0027984806 scopus 로고
    • The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway
    • Brunner D, Ducker K, Oellers N, Hafen E, Scholz H, Klambt C (1994) The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370: 386-389
    • (1994) Nature , vol.370 , pp. 386-389
    • Brunner, D.1    Ducker, K.2    Oellers, N.3    Hafen, E.4    Scholz, H.5    Klambt, C.6
  • 4
    • 0030866897 scopus 로고    scopus 로고
    • Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
    • Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ (1997) Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell 90: 859-869
    • (1997) Cell , vol.90 , pp. 859-869
    • Canagarajah, B.J.1    Khokhlatchev, A.2    Cobb, M.H.3    Goldsmith, E.J.4
  • 5
    • 0036670396 scopus 로고    scopus 로고
    • X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition
    • Dar AC, Sicheri F (2002) X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Mol Cell 10: 295-305
    • (2002) Mol Cell , vol.10 , pp. 295-305
    • Dar, A.C.1    Sicheri, F.2
  • 6
    • 20144386673 scopus 로고    scopus 로고
    • PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha
    • Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE (2005) PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol 25: 3063-3075
    • (2005) Mol Cell Biol , vol.25 , pp. 3063-3075
    • Dey, M.1    Trieselmann, B.2    Locke, E.G.3    Lu, J.4    Cao, C.5    Dar, A.C.6    Krishnamoorthy, T.7    Dong, J.8    Sicheri, F.9    Dever, T.E.10
  • 7
    • 10044283146 scopus 로고    scopus 로고
    • Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    • Foulds CE, Nelson ML, Blaszczak AG, Graves BJ (2004) Ras/mitogen- activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol 24: 10954-10964
    • (2004) Mol Cell Biol , vol.24 , pp. 10954-10964
    • Foulds, C.E.1    Nelson, M.L.2    Blaszczak, A.G.3    Graves, B.J.4
  • 8
    • 0025888298 scopus 로고
    • Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases
    • Gonzalez FA, Raden DL, Davis RJ (1991) Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J Biol Chem 266: 22159-22163
    • (1991) J Biol Chem , vol.266 , pp. 22159-22163
    • Gonzalez, F.A.1    Raden, D.L.2    Davis, R.J.3
  • 9
    • 0033529034 scopus 로고    scopus 로고
    • Protein modification: Docking sites for kinases
    • Holland PM, Cooper JA (1999) Protein modification: docking sites for kinases. Curr Biol 9: R329-R331
    • (1999) Curr Biol , vol.9
    • Holland, P.M.1    Cooper, J.A.2
  • 10
    • 0033555229 scopus 로고    scopus 로고
    • Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
    • Jacobs D, Glossip D, Xing H, Muslin AJ, Kornfeld K (1999) Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev 13: 163-175
    • (1999) Genes Dev , vol.13 , pp. 163-175
    • Jacobs, D.1    Glossip, D.2    Xing, H.3    Muslin, A.J.4    Kornfeld, K.5
  • 11
    • 0030966367 scopus 로고    scopus 로고
    • Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases
    • Khokhlatchev A, Xu S, English J, Wu P, Schaefer E, Cobb MH (1997) Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem 272: 11057-11062
    • (1997) J Biol Chem , vol.272 , pp. 11057-11062
    • Khokhlatchev, A.1    Xu, S.2    English, J.3    Wu, P.4    Schaefer, E.5    Cobb, M.H.6
  • 13
    • 0344196904 scopus 로고    scopus 로고
    • SAM domains: Uniform structure, diversity of function
    • Kim CA, Bowie JU (2003) SAM domains: uniform structure, diversity of function. Trends Biochem Sci 28: 625-628
    • (2003) Trends Biochem Sci , vol.28 , pp. 625-628
    • Kim, C.A.1    Bowie, J.U.2
  • 16
    • 23044476138 scopus 로고    scopus 로고
    • Structural organization of a sex-comb-on-midleg/polyhomeotic copolymer
    • Kim CA, Sawaya MR, Cascio D, Kim W, Bowie JU (2005) Structural organization of a sex-comb-on-midleg/polyhomeotic copolymer. J Biol Chem 280: 27769-27775
    • (2005) J Biol Chem , vol.280 , pp. 27769-27775
    • Kim, C.A.1    Sawaya, M.R.2    Cascio, D.3    Kim, W.4    Bowie, J.U.5
  • 17
    • 0027518831 scopus 로고
    • The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
    • Klambt C (1993) The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117: 163-176
    • (1993) Development , vol.117 , pp. 163-176
    • Klambt, C.1
  • 18
    • 0026723089 scopus 로고
    • Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
    • Lai ZC, Rubin GM (1992) Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70: 609-620
    • (1992) Cell , vol.70 , pp. 609-620
    • Lai, Z.C.1    Rubin, G.M.2
  • 21
    • 0028239896 scopus 로고
    • The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway
    • O'Neill EM, Rebay I, Tjian R, Rubin GM (1994) The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78: 137-147
    • (1994) Cell , vol.78 , pp. 137-147
    • O'Neill, E.M.1    Rebay, I.2    Tjian, R.3    Rubin, G.M.4
  • 22
    • 30344442873 scopus 로고    scopus 로고
    • The many faces of SAM
    • Qiao F, Bowie JU (2005) The many faces of SAM. Sci STKE 2005: re7
    • (2005) Sci STKE , vol.2005
    • Qiao, F.1    Bowie, J.U.2
  • 25
    • 4444228344 scopus 로고    scopus 로고
    • SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers
    • Ramachander R, Bowie JU (2004) SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers. J Mol Biol 342: 1353-1358
    • (2004) J Mol Biol , vol.342 , pp. 1353-1358
    • Ramachander, R.1    Bowie, J.U.2
  • 26
    • 0036430478 scopus 로고    scopus 로고
    • Keeping the receptor tyrosine kinase signaling pathway in check: Lessons from Drosophila
    • Rebay I (2002) Keeping the receptor tyrosine kinase signaling pathway in check: lessons from Drosophila. Dev Biol 251: 1-17
    • (2002) Dev Biol , vol.251 , pp. 1-17
    • Rebay, I.1
  • 27
    • 0029019928 scopus 로고
    • Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway
    • Rebay I, Rubin GM (1995) Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81: 857-866
    • (1995) Cell , vol.81 , pp. 857-866
    • Rebay, I.1    Rubin, G.M.2
  • 29
    • 0042622380 scopus 로고    scopus 로고
    • SWISS-MODEL: An automated protein homology-modeling server
    • Schwede T, Kopp J, Guex N, Peitsch MC (2003) SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 31: 3381-3385
    • (2003) Nucleic Acids Res , vol.31 , pp. 3381-3385
    • Schwede, T.1    Kopp, J.2    Guex, N.3    Peitsch, M.C.4
  • 30
    • 0036142763 scopus 로고    scopus 로고
    • An ERK2 docking site in the pointed domain distinguishes a subset of ETS transcription factors
    • Seidel JJ, Graves BJ (2002) An ERK2 docking site in the pointed domain distinguishes a subset of ETS transcription factors. Genes Dev 16: 127-137
    • (2002) Genes Dev , vol.16 , pp. 127-137
    • Seidel, J.J.1    Graves, B.J.2
  • 31
    • 0035515347 scopus 로고    scopus 로고
    • The ETS-domain transcription factor family
    • Sharrocks AD (2001) The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2: 827-837
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 827-837
    • Sharrocks, A.D.1
  • 32
    • 0034284131 scopus 로고    scopus 로고
    • Docking domains and substrate-specificity determination for MAP kinases
    • Sharrocks AD, Yang SH, Galanis A (2000) Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem Sci 25: 448-453
    • (2000) Trends Biochem Sci , vol.25 , pp. 448-453
    • Sharrocks, A.D.1    Yang, S.H.2    Galanis, A.3
  • 33
    • 0031715982 scopus 로고    scopus 로고
    • Protein structure alignment by incremental combinatorial extension (CE) of the optimal path
    • Shindyalov IN, Bourne PE (1998) Protein structure alignment by incremental combinatorial extension (CE) of the optimal path. Protein Eng 11: 739-747
    • (1998) Protein Eng , vol.11 , pp. 739-747
    • Shindyalov, I.N.1    Bourne, P.E.2
  • 35
    • 23744450036 scopus 로고    scopus 로고
    • Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response
    • Song H, Nie M, Qiao F, Bowie JU, Courey AJ (2005) Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Genes Dev 19: 1767-1772
    • (2005) Genes Dev , vol.19 , pp. 1767-1772
    • Song, H.1    Nie, M.2    Qiao, F.3    Bowie, J.U.4    Courey, A.J.5
  • 36
    • 0033118791 scopus 로고    scopus 로고
    • Signaling specificity: The RTK/RAS/MAP kinase pathway in metazoans
    • Tan PB, Kim SK (1999) Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 15: 145-149
    • (1999) Trends Genet , vol.15 , pp. 145-149
    • Tan, P.B.1    Kim, S.K.2
  • 37
    • 0037348614 scopus 로고    scopus 로고
    • CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE
    • Tootle TL, Lee PS, Rebay I (2003) CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Development 130: 845-857
    • (2003) Development , vol.130 , pp. 845-857
    • Tootle, T.L.1    Lee, P.S.2    Rebay, I.3
  • 38
    • 15944378903 scopus 로고    scopus 로고
    • Post-translational modifications influence transcription factor activity: A view from the ETS superfamily
    • Tootle TL, Rebay I (2005) Post-translational modifications influence transcription factor activity: a view from the ETS superfamily. Bioessays 27: 285-298
    • (2005) Bioessays , vol.27 , pp. 285-298
    • Tootle, T.L.1    Rebay, I.2
  • 39
    • 7044232153 scopus 로고    scopus 로고
    • MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN
    • Vivekanand P, Tootle TL, Rebay I (2004) MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Mech Dev 121: 1469-1479
    • (2004) Mech Dev , vol.121 , pp. 1469-1479
    • Vivekanand, P.1    Tootle, T.L.2    Rebay, I.3
  • 40
    • 0347417016 scopus 로고    scopus 로고
    • Signal integration during development: Insights from the Drosophila eye
    • Voas MG, Rebay I (2004) Signal integration during development: insights from the Drosophila eye. Dev Dyn 229: 162-175
    • (2004) Dev Dyn , vol.229 , pp. 162-175
    • Voas, M.G.1    Rebay, I.2
  • 41
    • 0042328139 scopus 로고    scopus 로고
    • EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed
    • Yamada T, Okabe M, Hiromi Y (2003) EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. Development 130: 4085-4096
    • (2003) Development , vol.130 , pp. 4085-4096
    • Yamada, T.1    Okabe, M.2    Hiromi, Y.3
  • 42
    • 0242361581 scopus 로고    scopus 로고
    • Transcriptional regulation by the MAP kinase signaling cascades
    • Yang SH, Sharrocks AD, Whitmarsh AJ (2003) Transcriptional regulation by the MAP kinase signaling cascades. Gene 320: 3-21
    • (2003) Gene , vol.320 , pp. 3-21
    • Yang, S.H.1    Sharrocks, A.D.2    Whitmarsh, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.