MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN

Mechanisms of Development

Volumn 121, Issue 12, 2004, Pages 1469-1479

  Vivekanand, Pavithra ^a   Tootle, Tina L ^a,b   Rebay, Ilaria ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Drosophila; Epidermal growth factor receptor; Ets transcription factor; Eye development; Pointed domain; Receptor tyrosine kinase; S2 cultured cells; Signal transduction

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PNT; TRANSCRIPTION FACTOR YAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EYE DEVELOPMENT; IN VIVO STUDY; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EYE; EYE ABNORMALITIES; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NERVE TISSUE PROTEINS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, INVERTEBRATE PEPTIDE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 7044232153     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mod.2004.07.009     Document Type: Article

References (30)

1. D.A. Baker, B. Mille-Baker, S.M. Wainwright, D. Ish-Horowicz, and N.J. Dibb Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila Nature 411 2001 330 334
2. T. Casci, J. Vinos, and M. Freeman Sprouty, an intracellular inhibitor of Ras signaling Cell 96 1999 655 665
3. R.G. Fehon, P.J. Kooh, I. Rebay, C.L. Regan, T. Xu, M.A. Muskavitch, and S. Artavanis-Tsakonas Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF homologous genes in Drosophila Cell 61 1990 523 534
4. R.G. Fehon, K. Johansen, I. Rebay, and S. Artavanis-Tsakonas Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function J. Cell Biol. 113 1991 657 669
5. G.V. Flores, H. Duan, H. Yan, R. Nagaraj, W. Fu, Y. Zou, M. Noll, and U. Banerjee Combinatorial signaling in the specification of unique cell fates Cell 103 2000 75 85
6. M. Freeman Feedback control of intercellular signalling in development Nature 408 2000 313 319
7. L. Gabay, H. Scholz, M. Golembo, A. Klaes, B.Z. Shilo, and C. Klambt EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm Development 122 1996 3355 3362
8. C. Ghiglione, K.L. Carraway III, L.T. Amundadottir, R.E. Boswell, N. Perrimon, and J.B. Duffy The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis Cell 96 1999 847 856
9. M. Golembo, R. Schweitzer, M. Freeman, and B.Z. Shilo Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop Development 122 1996 223 230
10. M.H. Jin, K. Sawamoto, M. Ito, and H. Okano The interaction between the Drosophila secreted protein argos and the epidermal growth factor receptor inhibits dimerization of the receptor and binding of secreted spitz to the receptor Mol. Cell Biol. 20 2000 2098 2107
11. C. Jousset, C. Carron, A. Boureux, C.T. Quang, C. Oury, I. Dusanter-Fourt, M. Charon, J. Levin, O. Bernard, and J. Ghysdael A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein Eur. Mol. Biol. Org. J. 16 1997 69 82
12. C.A. Kim, M.L. Phillips, W. Kim, M. Gingery, H.H. Tran, M.A. Robinson, S. Faham, and J.U. Bowie Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression Eur. Mol. Biol. Org. J. 20 2001 4173 4182
13. C. Klambt The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells Development 117 1993 163 176
14. C.J. Marshall MAP kinase kinase kinase, MAP kinase kinase and MAP kinase Curr. Opin. Genet. Dev. 4 1994 82 89
15. J.A. Nye, J.M. Petersen, C.V. Gunther, M.D. Jonsen, and B.J. Graves Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif Genes Dev. 6 1992 975 990
16. E.M. O'Neill, I. Rebay, R. Tjian, and G.M. Rubin The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway Cell 78 1994 137 147
17. E. Pascal, and R. Tjian Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism Genes Dev. 5 1991 1646 1656
18. F. Qiao, H. Song, C.A. Kim, M.R. Sawaya, J.B. Hunter, A.J. Courey, and J.U. Bowie Derepression by depolymerization:structural insights into the regulation of Yan by Mae Cell 118 2004 163 173
19. I. Rebay Keeping the receptor tyrosine kinase signaling pathway in check: lessons from Drosophila Dev. Biol. 251 2002 1 17
20. I. Rebay, and G.M. Rubin Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway Cell 81 1995 857 866
21. I. Rebay, F. Chen, F. Hsiao, P.A. Kolodziej, B.H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G.M. Rubin A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein Genetics 154 2000 695 712
22. M. Rohrbaugh, E. Ramos, D. Nguyen, M. Price, Y. Wen, and Z.C. Lai Notch Activation of yan Expression Is Antagonized by RTK/Pointed Signaling in the Drosophila Eye Curr. Biol. 12 2002 576 581
23. S.J. Silver, E.L. Davies, L. Doyon, and I. Rebay Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network Mol. Cell Biol. 23 2003 5989 5999
24. P.B. Tan, and S.K. Kim Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans Trends Genet. 15 1999 145 149
25. D. Tautz, and C. Pfeifle A non-radioactive in situ hybridization method for the localization of specific mRNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback Chromosoma 98 1989 81 85
26. A. Tomlinson, D.D. Bowtell, E. Hafen, and G.M. Rubin Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila Cell 51 1987 143 150
27. T.L. Tootle, P.S. Lee, and I. Rebay CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE Development 130 2003 845 857
28. C. Xu, R.C. Kauffmann, J. Zhang, S. Kladny, and R.W. Carthew Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye Cell 103 2000 87 97
29. T. Yamada, M. Okabe, and Y. Hiromi EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed Development 130 2003 4085 4096
30. S.L. Zipursky, and G.M. Rubin Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila Annu. Rev. Neurosci. 17 1994 373 397