Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila

Nature

Volumn 411, Issue 6835, 2001, Pages 330-334

  Baker, David A ^a,b   Mille Baker, Blandine ^a   Wainwright, S Mark ^b   Ish Horowicz, David ^b   Dibb, Nicholas J ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CLONING; SUBSTRATES;

PHOSPHORYLATION;

ENZYMES;

EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SERINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ACTIVATOR PROTEIN POINTED P2; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR MAE; TRANSCRIPTION FACTOR YAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DROSOPHILA; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE COMPLEX; LARVAL DEVELOPMENT; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BODY PATTERNING; CARRIER PROTEINS; DNA; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE PROTEINS; GENE EXPRESSION REGULATION; GENES, ESSENTIAL; GENES, REPORTER; IMMUNOHISTOCHEMISTRY; INSECT PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; HEXAPODA;

EID: 0035902045     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35077122     Document Type: Article

References (31)

1. Hill, C. S. & Treisman, R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80, 199-211 (1995).
2. Marshall, C. J. Specificity of receptor tyrosine kinase signalling; transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185 (1995).
3. Treisman, R. Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol. 8, 205-215 (1996).
4. Wasylyk, B., Hagman, J. & Gutierrez-Hartmann, A. Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. Trends Biochem. Sci. 23, 213-216 (1998).
5. Lai, Z. C. & Rubin, G. M. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70, 609-620 (1992).
6. Rebay, I. & Rubin, G. M. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 80, 857-866 (1995).
7. Rogge, R. et al. The role of yan in mediating the choice between cell division and differentiation. Development 121, 3947-3958 (1995).
8. Rebay, I. et al. A genetic screen for novel components of the Ras/mitogen-activeted protein kinase signalling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics 154, 695-712 (2000).
9. O'Neill, E. M., Rebay, I., Tjian, R. & Rubin, G. M. The activities of two ETS-related transcription factors required tor Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78, 137-147 (1994).
10. Jousset, C. et al. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL- PDGFRb oncoprotein. EMBO J. 16, 69-82 (1997).
11. Ponting, C. P. SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins. Protein Sci. 4, 1928-1930 (1995).
12. Nye, J. A. Interaction of murine ETS-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif. Genes Dev. 6, 975-990 (1992).
13. Soudant, S. et al. A residue in the ETS domain mutated in the v-ets oncogene is essential for the DNA-binding and transactivating properties of the ETS-1 and ETS-2 proteins. Nucleic Acids Res. 22, 3871-3879 (1994).
14. Klambt, C. The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of midline glial cells. Development 117, 163-176 (1993).
15. Brunner, D. et al. The ETS domain protein Pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370, 386-389 (1994).
16. Golembo, M., Raz, E. & Shilo, B.-Z. The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370 (1996).
17. Yagi, Y., Suzuki, T. & Hayashi, S. Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neurectoderm. Development 125, 3625-3633 (1998).
18. Gabay, I., et al. EGF receptor signalling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122, 3355-3362 (1996).
19. Golembo, M., Yarnitzky, T., Volk, T. & Shilo, B.-Z. Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm. Genes Dev. 13, 158-162 (1999).
20. Gabay, L., Seger, R. & Shilo, B.-Z. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 77, 1103-1106 (1997).
21. Durnstrei, K. et al. EGFR signalling is required for the differentiation and maintenance of neural progenitors along the dorsal midline of the Drosphila embryonic head. Development 125, 3417-3426 (1998).
22. Roch, F. et al. Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. Mol. Gen. Genet. 257, 103-112 (1998).
23. Spradling, A. C. et al. The Berkeley Drosophila genome gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153, 135-177 (1999).
24. Jurgens, G., Wieschaus, E., Nusslein-Volhard, C. & Kluding, H. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster II. Zygotic loci on the third chromosome. Roux's Arch. Dev. Biol. 193, 283-295 (1984).
25. Mayer, U. & Nusselein-Volhard, C. A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes Dev. 2, 1496-1503 (1988).
26. Wasserman, J. D., Urban, S. & Freeman, M. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signalling. Genes Dev. 14, 1651-1663 (2000).
27. Golembo, M., Schweitzer, R., Freeman, M. & Shilo, B.-Z. Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122, 223-230 (1996).
28. Scholz, H., Sadlowski, E., Klaes, A. & Klambt, C. Control of midline glia development in the embryonic Drosophila CNS. Mech. Dev. 64, 137-151 (1997).
29. Towbin, H., Staehelin, T. & Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl Acad. Sci. USA 76, 4350-4354 (1979).
30. Wieschaus, E. & Nusslein-Volhard, C. in Drosophila, a Practical Approach (ed. Roberts, D. B) 199-226 (IRL, Oxford, 1986).
31. Tautz, D. & Pfeifle, C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85 (1989).