Sustained poststimulus elevation in cerebral oxygen utilization after vascular recovery

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 7, 2004, Pages 764-770

  Lu, Hanzhang ^a,b   Golay, Xavier ^a,b,c   Pekar, James J ^a,b   Van Zijl, Peter C M ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

Author keywords

BOLD; Decoupling of Flow and Metabolism; Functional MRI; Oxygen utilization; Vascular recovery; VASO

Indexed keywords

OXYGEN;

ADULT; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; ENERGY METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; IMAGING SYSTEM; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN BLOOD LEVEL; PRIORITY JOURNAL; VISUAL STIMULATION;

EID: 3042812185     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000124322.60992.5C     Document Type: Article

References (39)

1. Ances BM, Buerk DG, Greenberg JH, Detre JA (2001) Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats. Neurosci Lett 306:106-110
2. Attwell D, Iadecola C (2002) The neural basis of functional brain imaging signals. Trends Neurosci 25:621-625
3. Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21:1133-1145
4. Brockhaus J, Ballanyi K, Smith JC, Richter DW (1993) Microenvironment of respiratory neurons in the in vitro brainstem-spinal cord of neonatal rats. J Physiol London 462:421-445
5. Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39:855-864
6. Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37-45
7. Devor A, Dunn AK, Andermann ML, Ulbert I, Boas DA, Dale AM (2003) Coupling of total hemoglobity concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron 39:353-359
8. Ernst T, Hennig J (1994) Observation of a fast response in functional MR. Magn Reson Med 32:146-149
9. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci U S A 83:1140-1144
10. Golay X, Silvennoinen MJ, Zhou J, Clingman CS, Kauppinen RA, Pekar JJ, van Zijl PC (2001) Measurement of tissue oxygen extraction ratios from venous blood T(2): increased precision and validation of principle. Magn Reson Med 46:282-291
11. Golay X, Stuber M, Pruessmann KP, Meier D, Boesiger, P (1999) Transfer insensitive labeling technique (TILT): application to multislice functional perfusion imaging. J Magn Reson Imaging 9:454-461
12. Gotoh J, Kuang TY, Nakao Y, Cohen DM, Melzer P, Itoh Y, Pak H, Pettigrew K, Sokoloff L (2001) Regional differences in mechanisms of cerebral circulatory response to neuronal activation. Am J Physiol Heart Circ Physiol 280:H821-H829
13. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci U S A 96:9403-9408
14. Koch RA, Barish ME (1994) Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. J Neurosci 14:2585-2593
15. Kuschinsky W (1996) Regulation of cerebral blood flow: an overview In: Neurophysiological basis of cerebral blood flow control an introduction (Mraovitch S, Sercombe R, eds), London: Johns Libbey & Company Ltd, pp 245-162
16. Kuschinsky W, Wahl M (1978) Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev 58:656-689
17. Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng HM, Brady TJ, Rosen BR (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A 89:5675-5679
18. Leenders KL, Perani D, Lammertsma AA, Heather JD, Buckingham P, Healy MJ, Gibbs JM, Wise RJ, Hatazawa J, Herold S, et al (1990) Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. Brain 113(pt 1):27-47
19. Li J, Iadecola C (1994) Nitric oxide and adenosine-mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology 33:1453-1461
20. Lindauer U, Megow D, Matsuda H, Dirnagl U (1999) Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. Am J Physiol 277:H799-H811
21. Logothetis NK (2002) The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal. Philos Trans R Soc Lond B Biol Sci 357:1003-1037
22. Lu H, Golay X, Pekar JJ, van Zijl PCM (2003) Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn Reson Med 50:263-274
23. Mandeville JB, Marota JJ, Ayata C, Zaharchuk G, Moskowitz MA, Rosen BR, Weisskoff RM (1999) Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 19:679-689
24. Mandeville JB, Marota JJ, Kosofsky BE, Keltner JR, Weissleder R, Rosen BR, Weisskoff RM (1998) Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med 39:615-624
25. Menon RS, Ogawa S, Hu X, Strupp JP, Anderson P, Ugurbil K (1995) BOLD based functional MRI at 4 Tesla includes a capillary bed contribution: echo-planar imaging correlates with previous optical imaging using intrinsic signals. Magn Reson Med 33:453-459
26. Mintun MA, Lundstrom BN, Snyder AZ, Vlassenko AG, Shulman GL, Raichle ME (2001) Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data. Proc Natl Acad Sci U S A 98:6859-6864
27. Ogawa S, Menon RS, Tank DW, Kim SG, Merkle H, Ellermann JM, Ugurbil K (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J 64:803-812
28. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 89:5951-5955
29. Oja JM, Gillen JS, Kauppinen RA, Kraut M, van Zijl PC (1999) Determination of oxygen extraction ratios by magnetic resonance imaging. J Cereb Blood Flow Metab 19:1289-1295
30. Pinard E, Tremblay E, Ben-Ari Y, Seylaz J (1984) Blood flow compensates oxygen demand in the vulnerable CA3 region of the hippocampus during kainate-induced seizures. Neuroscience 13: 1039-1049
31. Powers WJ, Hirsch IB, Cryer PE (1996) Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. Am J Physiol 270:H554-H559
32. Silvennoinen MJ, Clingman CS, Golay X, Kauppinen RA, van Zijl PC (2003) Comparison of the dependence of blood R2 and R2* on oxygen saturation at 1.5 and 4.7 Tesla. Magn Reson Med 49:47-60
33. Thompson JK, Peterson MR, Freeman RD (2003) Single-neuron activity and tissue oxygenation in the cerebral cortex. Science 299:1070-1072
34. Ugurbil K, Adriany G, Andersen P, Chen W, Gruetter R, Hu X, Merkle H, Kim DS, Kim SG, Strupp J, Zhu XH, Ogawa S (2000) Magnetic resonance studies of brain function and neurochemistry. Annu Rev Biomed Eng 2:633-660
35. Vafaee MS, Gjedde A (2000) Model of blood-brain transfer of oxygen explains nonlinear flow-metabolism coupling during stimulation of visual cortex. J Cereb Blood Flow Metab 20:747-754
36. van Zijl PC, Eleff SM, Ulatowski JA, Oja JM, Ulug AM, Traystman RJ, Kauppinen RA (1998) Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 4:159-167
37. Villringer A, Dirnagl U (1995) Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging. Cerebrovasc Brain Metab Rev 7:240-276
38. Yablonskiy DA, Haacke EM (1994) Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn Reson Med 32:749-763
39. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6:43-50