Determination of oxygen extraction ratios by magnetic resonance imaging

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 12, 1999, Pages 1289-1295

  Oja, Joni M E ^a   Gillen, Joseph S ^a   Kauppinen, Risto A ^b   Kraut, Michael ^a   Van Zijl, Peter C M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Magnetic resonance imaging; Mismatch; Oxygen extraction; Uncoupling

Indexed keywords

ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD OXYGENATION; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; MATHEMATICAL MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN AFFINITY; OXYGEN DISSOCIATION CURVE; PRIORITY JOURNAL; VENOUS BLOOD;

EID: 0033386478     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199912000-00001     Document Type: Article

References (17)

1. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS (1993) Processing strategies for time-course data sets in functional MRI of the brain. Magn Reson Med 30:161-173
2. Bandettini PA, Wong EC, Jesmanowicz A, Hinks RS, Hyde JS (1994) Spin-echo and gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1.5 T. NMR Biomed 7:12-20.
3. Brooks RA, Di Chiro G (1987) Magnetic resonance imaging of stationary blood: a review. Med Phys 14:903-913
4. Bryant RG, Marill K, Blackmore C, Francis C (1990) Magnetic relaxation in blood and blood clots. Magn Reson Med 13:133-144
5. Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17:64-72
6. Cohen PJ, Alexander SC, Smith FC, Reivich M, Wollman H (1967) Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J Appl Physiol 23:183-189
7. Davis TL, Kwong KK, Weisskoff RM, Rosen BR (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA 95:1834-1839
8. Fabry ME, San George RC (1983) Effect of magnetic susceptibility on nuclear magnetic resonance signals arising from red cells. Biochemistry 22:4119-4125
9. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proc Natl Acad Sci USA 83:1140-1144
10. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462-464
11. Frahm J, Merboldt K-D, Hänicke W (1993) Functional MRI of human brain activation at high spatial resolution. Magn Reson Med 29:139-144
12. Furlan M, Marchal G, Viader F, Derlon J-M, Baron J-C (1996) Spontaneous neurological recovery after stroke and the fate of the ischemic penumbra. Ann Neurol 40:216-226
13. Gati JS, Menon RS, Ugurbil K, Rutt BK (1997) Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 38:296-302
14. Gillis P, Petö S, Moiny F, Mispelter J, Cuenod C-A (1995) Proton transverse nuclear magnetic relaxation in oxidized blood: a numerical approach. Magn Reson Med 33:93-100
15. Gjedde A (1997) The relation between brain function and cerebral blood flow and metabolism. Philadelphia, PA, Lippincott-Raven Publishers
16. Gomori JM, Grossman RI, Yu-Ip C, Asakura T (1987) NMR relaxation times of blood: dependence on field strength, oxidation state, and cell integrity. J Comput Assist Tomog 11:684-690
17. Gröhn OHJ, Lukkarinen JA, Oja JME, et al. (1998) Noninvasive detection of cerebral hypoperfusion and reversible ischemia from reductions in the magnetic resonance imaging relaxation time, T2. J Cereb Blood Flow Metab 18:911-920