The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion

Molecular and Cellular Endocrinology

Volumn 165, Issue 1-2, 2000, Pages 199-209

  Cicatiello, Luigi ^a   Addeo, Raffaele ^a   Altucci, Lucia ^a   Belsito Petrizzi, Valeria ^a   Boccia, Vincenzo ^a   Cancemi, Massimo ^a   Germano, Domenico ^a   Pacilio, Carmen ^a   Salzano, Salvatore ^b   Bresciani, Francesco ^a   Weisz, Alessandro ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Antiestrogen; Breast cancer; Cell cycle; Cyclin; Estrogen; Retinoblastoma protein

Indexed keywords

ANTIESTROGEN; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLINE; ESTRADIOL; FULVESTRANT; RETINOBLASTOMA PROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BREAST NEOPLASMS; CELL CYCLE; CELL DIVISION; CYCLIN-DEPENDENT KINASES; CYCLINS; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; FEMALE; HUMANS; NEOPLASMS, HORMONE-DEPENDENT; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TUMOR CELLS, CULTURED;

EID: 0034713764     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(00)00243-4     Document Type: Article

References (37)

1. cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G1-arrested human breast cancer cells. Oncogene. 12:1996;2315-2324.
2. Altucci L., Addeo R., Cicatiello L., Germano D., Pacilio C., Battista T., Cancemi M., Belsito Petrizzi V., Bresciani F., Weisz A. Estrogen induce early and timed activation of cyclin-dependent kinases 4, 5 and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. Endocrinology. 138:1997;978-984.
3. Bonapace I.M., Addeo R., Altucci L., Cicatiello L., Bifulco M., Laezza C., Salzano S., Sica V., Bresciani F., Weisz A 17β-estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinase activation. Oncogene. 12:1996;753-763.
4. Bresciani F. DNA synthesis in alveolar cells of the mammary gland: acceleration by ovarian hormones. Science. 146:1964;653-655.
5. Cicatiello L., Sica V., Bresciani F., Weisz A. Identification of a specific pattern of 'immediate-early' gene activation induced by estrogen during mitogenic stimulation of rat uterine cells. Receptor. 3:1993;17-30.
6. Dauvois S., Danielian P.S., White R., Parker M.G. Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. Proc. Natl. Acad. Sci. USA. 89:1992;4037-4041.
7. Davidson N.E., Lippman M.E. The role of estrogens in growth regulation of breast cancer. CRC Rev. Oncogenesis. 1:1989;89-111.
8. Dubik D., Shiu R.P.C. Mechanism of estrogen activation of c-myc oncogene expression. Oncogene. 7:1992;1587-1594.
9. Foster J.S., Wimalasena J. Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells. Mol. Endocrinol. 10:1996;488-498.
10. Grana X., Reddy E.P. Cell cycle control in mammalian cells: role of cyclins, cyclin-dependent kinases, growth suppressor genes and cyclin-dependent kinase inhibitors. Oncogene. 11:1995;211-219.
11. Gronemeyer H., Benhamou B., Berry M., Bocquel M.T., Gofflo D., Garcia T., Lerouge T., Metzger D., Meyer M.E., Tora L., Vergazac A., Chambon P. Mechanisms of antihormone action. J. Steroid Biochem. Mol. Biol. 41:1992;217-221.
12. Howell A., DeFriend D., Anderson E. Mechanisms of response and resistance to endocrine therapy for breast cancer and the development of new treatments. Rev. Endocrine-Rel. Cancer. 43:1993;5-21.
13. Hyder S.M., Nawaz Z., Chappetta C., Yokoyama K., Stancel G.M. The protooncogene c-jun contains an unusual estrogen-inducible enhancer within the coding sequence. J. Biol. Chem. 270:1995;8506-8513.
14. Keyomarsi K., Sandoval L., Band V., Pardee A.B. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res. 51:1991;3602-3609.
15. Lukas J., Bartkova J., Bartek J. Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol. Cell. Biol. 16:1996;6917-6925.
16. Lucas J., Bartkova J., Welcker M., Petersen O.W., Peters G., Strauss M., Barteck J. Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene. 10:1995;2125-2134.
17. Masiakowski P., Breathnach R., Bloch J., Gannon F., Krust A., Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res. 10:1982;7895-7903.
18. Musgrove E.A., Wakeling A.E., Sutherland R.L. Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle. Cancer Res. 49:1989;2398-2404.
19. Osborne C.K., Coronado-Heinsohn E.B., Hilsenbeck S.G., McCue B.L., Wakeling A.E., Manning D.L., Nicholson R.I. Comparative effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancer. J. Natl. Cancer Inst. 87:1995;746-750.
20. Parker M.G. Action of "pure" antiestrogens in inhibiting estrogen receptor action. Breast Cancer Res. Treat. 26:1993;131-137.
21. Ohtsubo M., Theodoras A.M., Schumacher J., Roberts J.M., Pagano M. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol. Cell. Biol. 15:1995;2612-2624.
22. Pacilio C., Germano D., Addeo R., Altucci L., Belsito Petrizzi V., Cancemi M., Cicatiello L., Salzano S., Lallemand F., Michalides R.J.A.M., Bresciani F., Weisz A. Constitutive overexpression of cyclin D1 does not prevent inhibition of hormone-responsive human breast cancer cells by antiestrogens. Cancer Res. 58:1998;871-876.
23. Persico E., Scalona M., Cicatiello L., Sica V., Bresciani F., Weisz A. Activation of 'immediate-early' genes by estrogen is not sufficient to achieve stimulation of DNA synthesis in rat uterus. Biochem. Biophys. Res. Commun. 171:1990;287-292.
24. Planas-Silva M.D., Weinberg R.A. Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol. Cell. Biol. 17:1997;4059-4069.
25. Prall O.W.J., Sarcevic B., Musgrove E., Watts C.K.W., Sutherland R.L. Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J. Biol. Chem. 272:1997;10882-10894.
26. Seyler-Tuyns A., Birnstiel M.L. Structure and expression in L-cells of a cloned H4 histone gene of the mouse. J. Mol. Biol. 151:1981;607-625.
27. Sherr C.J., Roberts J.M. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1995;1149-1163.
28. Stack G., Gorski J. Estrogen-stimulated deoxyribonucleic acid synthesis: a ratchet model for the prereplicative period. Endocrinology. 117:1985;2017-2023.
29. Stiles C.D., Capone G.T., Scher C.D., Antoniades H.N., Van Wyk J.J., Pledger W.J. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc. Natl. Acad. Sci. USA. 76:1979;1279-1288.
30. Wakeling A.E., Newboult E., Peters S.W. Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells. J. Mol. Endocrinol. 2:1989;225-234.
31. Wakeling A.E., Dukes M., Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res. 51:1991;3867-7383.
32. Watts C.K.W., Brady A., Sarcevic B., deFazio A., Musgrove E.A., Sutherland R.L. Antiestrogen inhibition of cell cycle progression in breast cancer cells is associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation. Mol. Endocrinol. 9:1995;1804-1813.
33. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell. 81:1995;323-330.
34. Weisz A., Addeo R., Altucci L., Battista T., Boccia V., Cancemi M., Cicatiello L., Germano L., Mancini A., Pacilio C., Bresciani F. Molecular mechanisms for estrogen control of cell cycle progression during G1. Kuramoto H., Gurpide E. In Vitro Biology of Sex Steroid Hormone Action. 1996;1-16 Churchill Livingstone, Tokyo.
35. Weisz A., Bresciani F. Estrogen regulation of proto-oncogenes coding for nuclear proteins. CRC Rev. Oncogenesis. 4:1993;361-388.
36. Weisz A., Cicatiello L., Persico E., Scalona M., Bresciani F. Estrogen stimulates transcription of c-jun protooncogene. Mol. Endocrinol. 4:1990;1041-1050.
37. Weisz A., Rosales R. Identification of an estrogen response element upstream of the human c-fos proto-oncogene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res. 18:1990;5097-5106.