-
1
-
-
0042020173
-
Treatment of Alzheimer's disease: Current status and new perspectives
-
Scarpini E, Scheltens P, Feldman H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2003;2:539-547.
-
(2003)
Lancet Neurol
, vol.2
, pp. 539-547
-
-
Scarpini, E.1
Scheltens, P.2
Feldman, H.3
-
2
-
-
0036736218
-
Amyloid precursor protein, presenilins, and α-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
-
Suh Y-H, Checler F. Amyloid precursor protein, presenilins, and α-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev. 2002;54:469-525.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 469-525
-
-
Suh, Y.-H.1
Checler, F.2
-
3
-
-
0141763668
-
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis
-
Lanctot KL, Herrmann N, Yau KK, et al. Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis. CMAJ. 2003; 169:557-564.
-
(2003)
CMAJ
, vol.169
, pp. 557-564
-
-
Lanctot, K.L.1
Herrmann, N.2
Yau, K.K.3
-
4
-
-
0141954291
-
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease
-
Rogawski MA, Wenk GL. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev. 2003; 9:275-308.
-
(2003)
CNS Drug Rev
, vol.9
, pp. 275-308
-
-
Rogawski, M.A.1
Wenk, G.L.2
-
5
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
-
Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291:317-324.
-
(2004)
JAMA
, vol.291
, pp. 317-324
-
-
Tariot, P.N.1
Farlow, M.R.2
Grossberg, G.T.3
-
6
-
-
0029620841
-
A new cognition-enhancing agent, (R)-(-)-1-(benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol hydrochloride.: Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions
-
Ono S, Yamafuji T, Chaki H, et al. A new cognition-enhancing agent, (R)-(-)-1-(benzo [b] thiophen-5-yl)-2-[2-(N, N-diethylamino) ethoxy] ethanol hydrochloride.: effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions. Biol Pharm Bull. 1995; 18:1779-1783.
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 1779-1783
-
-
Ono, S.1
Yamafuji, T.2
Chaki, H.3
-
7
-
-
0038306162
-
Protective effect of T-588 on toxic damage by serum deprivation and amyloid-β protein in cultured neurons
-
Yamamuro A, Ago Y, Maeda S, et al. Protective effect of T-588 on toxic damage by serum deprivation and amyloid-β protein in cultured neurons. J Pharmacol Sci. 2003;92:153-156.
-
(2003)
J Pharmacol Sci
, vol.92
, pp. 153-156
-
-
Yamamuro, A.1
Ago, Y.2
Maeda, S.3
-
8
-
-
0036263210
-
Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: Suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits
-
Tateishi N, Mori T, Kagamiishi Y, et al. Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurologic deficits. J Cereb Blood Flow Metab. 2002;22:723-734.
-
(2002)
J Cereb Blood Flow Metab
, vol.22
, pp. 723-734
-
-
Tateishi, N.1
Mori, T.2
Kagamiishi, Y.3
-
9
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001;81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
10
-
-
0037010298
-
β-Secretase as a target for the treatment of Alzheimer's disease
-
Citron M. β-Secretase as a target for the treatment of Alzheimer's disease. J Neurosci Res. 2002; 70:373-379.
-
(2002)
J Neurosci Res
, vol.70
, pp. 373-379
-
-
Citron, M.1
-
11
-
-
0037468759
-
The role of presenilin cofactors in the γ-secretase complex
-
Takasugi N, Tomita T, Hayashi I, et al. The role of presenilin cofactors in the γ-secretase complex. Nature. 2003;422:438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
-
13
-
-
1642441331
-
Pharmacology of selective acetylcholinesterase inhibitors: Implications for use in Alzheimer's disease
-
Liston DR, Nielsen JA, Villalobos A, et al. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease. Eur J Pharmacol. 2004;486:9-17.
-
(2004)
Eur J Pharmacol
, vol.486
, pp. 9-17
-
-
Liston, D.R.1
Nielsen, J.A.2
Villalobos, A.3
-
14
-
-
0031911138
-
Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons
-
Akaike A, Maeda T, Kaneko S, Tamura Y. Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons. Jpn J Pharmacol. 1998;76:219-222.
-
(1998)
Jpn J Pharmacol
, vol.76
, pp. 219-222
-
-
Akaike, A.1
Maeda, T.2
Kaneko, S.3
Tamura, Y.4
-
15
-
-
0142092495
-
Human β-secretase (BACE) and BACE inhibitors
-
John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. Human β-secretase (BACE) and BACE inhibitors. J Med Chem. 2003;46:4625-4630.
-
(2003)
J Med Chem
, vol.46
, pp. 4625-4630
-
-
John, V.1
Beck, J.P.2
Bienkowski, M.J.3
Sinha, S.4
Heinrikson, R.L.5
-
16
-
-
0038476561
-
The γ-secretase inhibitor N-EN-(3,5-difluorophenacetyl)-L-alanyl]- S-phenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice
-
Lanz TA, Himes CS, Pallante G, et al. The γ-secretase inhibitor N-EN-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice. J Pharmacol Exp Ther. 2003;305:864-871.
-
(2003)
J Pharmacol Exp Ther
, vol.305
, pp. 864-871
-
-
Lanz, T.A.1
Himes, C.S.2
Pallante, G.3
-
17
-
-
0242330368
-
JLK isocoumarin inhibitors: Selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo
-
Petit A, Pasini A, Costa CA, et al. JLK isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo. J Neurosci Res. 2003;74:370-377.
-
(2003)
J Neurosci Res
, vol.74
, pp. 370-377
-
-
Petit, A.1
Pasini, A.2
Costa, C.A.3
-
18
-
-
0042206671
-
The mechanism of γ-secretase: Multiple inhibitor binding sites for transition state analogs and small molecule inhibitors
-
Tian G, Ghanekar SV, Aharony D, et al. The mechanism of γ-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors. J Biol Chem. 2003;278:28968-28975.
-
(2003)
J Biol Chem
, vol.278
, pp. 28968-28975
-
-
Tian, G.1
Ghanekar, S.V.2
Aharony, D.3
-
19
-
-
0036848056
-
A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro
-
Nakagami Y, Nishimura S, Murasugi T, et al. A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro. Br J Pharmacol. 2002; 137:676-682.
-
(2002)
Br J Pharmacol
, vol.137
, pp. 676-682
-
-
Nakagami, Y.1
Nishimura, S.2
Murasugi, T.3
-
20
-
-
0242268945
-
Immunotherapeutic approaches to Alzheimer's disease
-
Monsonego A, Weiner HL. Immunotherapeutic approaches to Alzheimer's disease. Science. 2003;302:834-838.
-
(2003)
Science
, vol.302
, pp. 834-838
-
-
Monsonego, A.1
Weiner, H.L.2
-
21
-
-
3042791725
-
-
Japanese source
-
-
-
-
23
-
-
0242609178
-
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator- activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase
-
Sastre M, Dewachter I, Landreth GE, et al. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-γ agonists modulate immunostimulated processing of amyloid precursor protein through regulation of β-secretase. J Neurosci. 2003;23:9796-9804.
-
(2003)
J Neurosci
, vol.23
, pp. 9796-9804
-
-
Sastre, M.1
Dewachter, I.2
Landreth, G.E.3
-
24
-
-
9144219644
-
Cyclooxygenase (COX)-2 and COX-1 potentiate β-amyloid peptide generation through mechanisms that involve γ-secretase activity
-
Qin W, Ho L, Pompl PN, et al. Cyclooxygenase (COX)-2 and COX-1 potentiate β-amyloid peptide generation through mechanisms that involve γ-secretase activity. J Biol Chem. 2003;278:50970-50977.
-
(2003)
J Biol Chem
, vol.278
, pp. 50970-50977
-
-
Qin, W.1
Ho, L.2
Pompl, P.N.3
-
25
-
-
0037359765
-
Apolipoprotein E and cholesterol metabolism in the pathogensis and treatment of Alzheimer's disease
-
Poirier J. Apolipoprotein E and cholesterol metabolism in the pathogensis and treatment of Alzheimer's disease. Trends Mol Med. 2003;94-101.
-
(2003)
Trends Mol Med
, pp. 94-101
-
-
Poirier, J.1
-
26
-
-
0344256425
-
Mild cognitive impairment: New neuropsychological and pharmacological target
-
Rivas-Vazquez RA, Mendez C, Rey GJ, et al. Mild cognitive impairment: new neuropsychological and pharmacological target. Arch Clin Neuropsychol. 2004;19:11-27.
-
(2004)
Arch Clin Neuropsychol
, vol.19
, pp. 11-27
-
-
Rivas-Vazquez, R.A.1
Mendez, C.2
Rey, G.J.3
|