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Volumn 3, Issue 5, 2001, Pages 421-426

Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones

Author keywords

[No Author keywords available]

Indexed keywords

ACETOPHENONE DERIVATIVE; ANTINEOPLASTIC AGENT; CHALCONE; DIAGNOSTIC AGENT; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

EID: 0035465012     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc000075z     Document Type: Article
Times cited : (84)

References (42)
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    • For recent reports on the solution- and solid-phase synthesis of chalcone libraries for other purposes see the following. Powers, D. G.; Casebier, D. S.; Fokas, D.; Ryan, W. J.; Troth, J. R.; Coffen, D. L. Tetrahedron 1998, 54, 4085-4096. Marzinzik, A. L.; Felder, E. R. J. Org. Chem. 1998, 63, 723- 727. Katritzky, A. R.; Serdyuk, L.; Chassaing, C.; Toader, D.; Wang, X.; Forood, B.; Flatt, B.; Sun, C.; Vo, K. J. Comb. Chem. 2000, 2, 182-185.
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    • For recent reports on the solution- and solid-phase synthesis of chalcone libraries for other purposes see the following. Powers, D. G.; Casebier, D. S.; Fokas, D.; Ryan, W. J.; Troth, J. R.; Coffen, D. L. Tetrahedron 1998, 54, 4085-4096. Marzinzik, A. L.; Felder, E. R. J. Org. Chem. 1998, 63, 723-727. Katritzky, A. R.; Serdyuk, L.; Chassaing, C.; Toader, D.; Wang, X.; Forood, B.; Flatt, B.; Sun, C.; Vo, K. J. Comb. Chem. 2000, 2, 182-185.
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    • note
    • Controls for the aldehydes and ketones were not performed because we had previously found that those used were not cytotoxic. In principle, these could be performed by assessing the cytotoxicity at the same single value (5 μM) used for the library.
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    • note
    • Random sampling of 32 wells revealed that 60% were essentially composed of only the expected chalcone; of the other 40% most were mixtures of the benzaldehyde, acetophenone, and chalcone.
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