Parallel synthesis and structure-activity relationships of a series of highly potent, selective, and neutral factor Xa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 15, 2004, Pages 4045-4050

  Bauer, Shawn M ^a   Goldman, Erick A ^a   Huang, Wenrong ^a   Su, Ting ^a   Wang, Lingyan ^a   Woolfrey, John ^a   Wu, Yanhong ^a   Zuckett, Jingmei F ^a   Arfsten, Ann ^a   Huang, Brian ^a   Kothule, Jaya ^a   Lin, Joyce ^a   May, Bridget ^a   Sinha, Uma ^a   Wong, Paul W ^a   Hutchaleelaha, Athiwat ^a   Scarborough, Robert M ^a   Zhu, Bing Yan ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Amino acid; Aspartic acid; Factor Xa; SAR

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTITHROMBIN III; ENZYME INHIBITORS; FACTOR XA; HUMANS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042594191     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.033     Document Type: Article

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