Coagulation factor Xa: The prothrombinase complex as an emerging therapeutic target for small molecule inhibitors

Journal of Enzyme Inhibition

Volumn 14, Issue 1, 1998, Pages 15-25

  Scarborough, Robert M ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Anticoagulant activity; Antithrombotic activity; Factor Xa; Non peptide reversible inhibitors; Prothrombinase complex; Transition state inhibitors

Indexed keywords

2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; 2,6 BIS(3 AMIDINOPHENOXY) 3,5 DIFLUORO 4 METHYLPYRIDINE; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BX 807834; HEPARIN; N ACETYL 4 (AMINOIMINOMETHYL)PHENYLALANYL 2 CYCLOHEXYLGLYCYL 3 (1 METHYLPYRIDINIUM 3 YL) ALANYLLEUCYLPROLINAMIDE; N [1 (2 AMINOIMINOMETHYL 4 THIENYLMETHYL) 2 OXO 3 PYRROLIDINYL] 7 METHOXY N METHYL 2 NAPHTHALENESULFONAMIDE; RPR 130737; SEL 2489; UNCLASSIFIED DRUG; ZK 805412; ZK 806530; ZK 807191; [N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID;

DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TARGETING; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; THROMBOCYTE AGGREGATION INHIBITION; VEIN THROMBOSIS;

OXY;

EID: 0032432971     PISSN: 87555093     EISSN: None     Source Type: Journal    
DOI: 10.3109/14756369809036543     Document Type: Review

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