Inhibition of factor Xa by a peptidyl-α-ketothiazole involves two steps. Evidence for a stabilizing conformational change

Biochemistry

Volumn 38, Issue 44, 1999, Pages 14582-14591

  Betz, Andreas ^a   Wong, Paul W ^a   Sinha, Uma ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENESULFONYL DEXTRO ARGINYLGLYCYLARGINYL ALPHA KETOTHIAZOLE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; DANSYLGLUTAMYLGLYCYLARGININE CHLOROMETHYL KETONE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITOR INTERACTION; EQUILIBRIUM CONSTANT; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; ENZYME STABILITY; FACTOR XA; HUMANS; KINETICS; OLIGOPEPTIDES; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS; SPECTROMETRY, FLUORESCENCE; THIAZOLES; THROMBOPLASTIN;

EID: 0033517788     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990958a     Document Type: Article

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