Mutation of tyrosine 383 in leukotriene A4 hydrolase allows conversion of leukotriene A4 into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid: Implications for the epoxide hydrolase mechanism

Journal of Biological Chemistry

Volumn 272, Issue 37, 1997, Pages 23057-23063

  Andberg, Martina Blomster ^a   Hamberg, Mats ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EPOXIDE HYDROLASE; LEUKOTRIENE A4; LEUKOTRIENE A4 HYDROLASE; RECOMBINANT PROTEIN; XENOBIOTIC AGENT;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINOPEPTIDASES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPOXIDE HYDROLASES; HYDROXYEICOSATETRAENOIC ACIDS; LEUCINE; LEUKOTRIENE A4; LEUKOTRIENE B4; MASS SPECTROMETRY; METALLOPROTEINS; MICE; MODELS, CHEMICAL; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; SPECTROPHOTOMETRY, ULTRAVIOLET; TYROSINE; ZINC;

ESCHERICHIA COLI; GLYCINE MAX;

EID: 0030819492     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.37.23057     Document Type: Article

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