-
1
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor, J. P., Hardy, J., and Fischbeck, K. H. (2002) Toxic proteins in neurodegenerative disease. Science 296, 1991-1995.
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
2
-
-
0032814135
-
Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?
-
Small, D. H., and McLean, C. A. (1999) Alzheimer's disease and the amyloid beta protein: What is the role of amyloid? J. Neurochem. 73, 443-449.
-
(1999)
J. Neurochem.
, vol.73
, pp. 443-449
-
-
Small, D.H.1
McLean, C.A.2
-
3
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870.
-
(1996)
Nature Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
-
4
-
-
0035433962
-
Alzheimer's disease and Abeta toxicity: From top to bottom
-
Small, D. H., Mok, S. S., and Bornstein, J. C. (2001) Alzheimer's disease and Abeta toxicity: from top to bottom. Nat. Rev. Neurosci. 2, 595-598.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
5
-
-
0036833437
-
Therapeutic strategies for Alzheimer's disease
-
Wolfe, M. S. (2002) Therapeutic strategies for Alzheimer's disease. Nat. Rev. Drug Dis. 1, 859-866.
-
(2002)
Nat. Rev. Drug Dis.
, vol.1
, pp. 859-866
-
-
Wolfe, M.S.1
-
6
-
-
0035912829
-
Gamma-secretase inhibitors repress thymocyte development
-
Hadland, B. K., Manley, N. R., Su, D. M., Longmore, G. D., Moore, C. L., Wolfe, M. S., Schroeter, E. H., and Kopan, R. (2001) Gamma-secretase inhibitors repress thymocyte development. Proc. Natl. Acad. Sci. USA 98, 7487-7491.
-
(2001)
Proc. Natl. Acad. Sci. USA.
, vol.98
, pp. 7487-7491
-
-
Hadland, B.K.1
Manley, N.R.2
Su, D.M.3
Longmore, G.D.4
Moore, C.L.5
Wolfe, M.S.6
Schroeter, E.H.7
Kopan, R.8
-
7
-
-
0034797234
-
The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
-
Nunan, J., Shearman, M. S., Checler, F., Cappai, R., Evin, G., Beyreuther, K., Masters, C. L., and Small, D. H. (2001) The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase. Eur. J. Biochem. 268, 5329-5336.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 5329-5336
-
-
Nunan, J.1
Shearman, M.S.2
Checler, F.3
Cappai, R.4
Evin, G.5
Beyreuther, K.6
Masters, C.L.7
Small, D.H.8
-
8
-
-
0242330370
-
Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: Effect of C-terminal truncation on production of beta-amyloid protein
-
Nunan, J., Williamson, N., Hill, A. F., Sernee, M. F., Masters, C. L., and Small, D. H. (2003) Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. J. Neurosci. Res. 74, 378-385.
-
(2003)
J. Neurosci. Res.
, vol.74
, pp. 378-385
-
-
Nunan, J.1
Williamson, N.2
Hill, A.F.3
Sernee, M.F.4
Masters, C.L.5
Small, D.H.6
-
9
-
-
0036780877
-
Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
-
Schenk, D. (2002) Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 3, 824-828.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 824-828
-
-
Schenk, D.1
-
10
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979-982.
-
(2000)
Nature
, vol.408
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
Chishti, M.A.7
Horne, P.8
Heslin, D.9
French, J.10
-
11
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
-
Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., and Weller, R. O. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nature Med. 9, 448-452.
-
(2003)
Nature Med.
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.R.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
12
-
-
0038100154
-
Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
-
Hock, C., Konietzko, U., Streffer, J. R., Tracy, J., Signorell, A., Muller-Tillmanns, B., Lemke, U., Henke, K., Moritz, E., Garcia, E., et al. (2003) Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. Neuron 38, 547-554.
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
Tracy, J.4
Signorell, A.5
Muller-Tillmanns, B.6
Lemke, U.7
Henke, K.8
Moritz, E.9
Garcia, E.10
-
13
-
-
0032773427
-
Amyloid and lipids in the pathology of Alzheimer disease
-
Roher, A. E., Kuo, Y. M., Kokjohn, K. M., Emmerling, M. R., and Gracon, S. (1999) Amyloid and lipids in the pathology of Alzheimer disease. Amyloid 6, 136-145.
-
(1999)
Amyloid
, vol.6
, pp. 136-145
-
-
Roher, A.E.1
Kuo, Y.M.2
Kokjohn, K.M.3
Emmerling, M.R.4
Gracon, S.5
-
14
-
-
0034638746
-
Statins and the risk of dementia
-
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A. (2000) Statins and the risk of dementia. Lancet 356, 1627-1631.
-
(2000)
Lancet
, vol.356
, pp. 1627-1631
-
-
Jick, H.1
Zornberg, G.L.2
Jick, S.S.3
Seshadri, S.4
Drachman, D.A.5
-
15
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G., and Siegel, G. (2000) Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57, 1439-1443.
-
(2000)
Arch. Neurol.
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
16
-
-
0035160066
-
A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease
-
Refolo, L. M., Pappolla, M. A., LaFrancois, J., Malester, B., Schmidt, S. D., Thomas-Bryant, T., Tint, G. S., Wang, R., Mercken, M., Petanceska, S. S., et al. (2001) A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8, 890-899.
-
(2001)
Neurobiol. Dis.
, vol.8
, pp. 890-899
-
-
Refolo, L.M.1
Pappolla, M.A.2
LaFrancois, J.3
Malester, B.4
Schmidt, S.D.5
Thomas-Bryant, T.6
Tint, G.S.7
Wang, R.8
Mercken, M.9
Petanceska, S.S.10
-
17
-
-
0033833354
-
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
-
Refolo, L. M., Pappolla, J., Malester, M. A., LaFrancois B., Thomas-Bryant, T., Wang, R., Tint, G. S., Sambamurti, K., and Duff, K. E. (2000) Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol. Dis. 7, 321-331.
-
(2000)
Neurobiol. Dis.
, vol.7
, pp. 321-331
-
-
Refolo, L.M.1
Pappolla, J.2
Malester, M.A.3
LaFrancois, B.4
Thomas-Bryant, T.5
Wang, R.6
Tint, G.S.7
Sambamurti, K.8
Duff, K.E.9
-
18
-
-
0037312139
-
Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes
-
Subasinghe, S., Unabia, S., Barrow, C. J., Mok, S. S., Aguilar, M. I., and Small, D. H. (2003) Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes. J. Neurochem. 84, 471-479.
-
(2003)
J. Neurochem.
, vol.84
, pp. 471-479
-
-
Subasinghe, S.1
Unabia, S.2
Barrow, C.J.3
Mok, S.S.4
Aguilar, M.I.5
Small, D.H.6
-
19
-
-
0027398069
-
The diversity of neuronal nicotinic acetylcholine receptors
-
Sargent, P. B. (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16, 403-443.
-
(1993)
Annu. Rev. Neurosci.
, vol.16
, pp. 403-443
-
-
Sargent, P.B.1
-
20
-
-
0030756236
-
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
-
Kihara, T., Shimohama, S., Sawada, H., Kimura, J., Kume, T., Kochiyama, H., Maeda, T., and Akaike, A. (1997) Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Ann. Neurol. 42, 159-163.
-
(1997)
Ann. Neurol.
, vol.42
, pp. 159-163
-
-
Kihara, T.1
Shimohama, S.2
Sawada, H.3
Kimura, J.4
Kume, T.5
Kochiyama, H.6
Maeda, T.7
Akaike, A.8
-
21
-
-
0032507506
-
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity
-
Kihara, T., Shimohama, S., Urushitani, M., Sawada, H., Kimura, J., Kume, T., Maeda, T., and Akaike, A. (1998) Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity. Brain Res. 792, 331-334.
-
(1998)
Brain Res.
, vol.792
, pp. 331-334
-
-
Kihara, T.1
Shimohama, S.2
Urushitani, M.3
Sawada, H.4
Kimura, J.5
Kume, T.6
Maeda, T.7
Akaike, A.8
-
22
-
-
0020083001
-
Cigarette smoking and state-dependent memory
-
Peters, R., and McGee, R. (1982) Cigarette smoking and state-dependent memory. Psychopharmacology (Berl.) 76, 232-235.
-
(1982)
Psychopharmacology (Berl.)
, vol.76
, pp. 232-235
-
-
Peters, R.1
McGee, R.2
-
23
-
-
0032589578
-
The alpha7 nicotinic acetylcholine receptor in neuronal plasticity
-
Broide, R. S., and Leslie, F. M. (1999) The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 20, 1-16.
-
(1999)
Mol. Neurobiol.
, vol.20
, pp. 1-16
-
-
Broide, R.S.1
Leslie, F.M.2
-
24
-
-
0042357192
-
Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation
-
Wang, H. Y., Li, W., Benedetti, N. J., and Lee, D. H. (2003) Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J. Biol. Chem. 278, 31547-31553.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31547-31553
-
-
Wang, H.Y.1
Li, W.2
Benedetti, N.J.3
Lee, D.H.4
-
25
-
-
1442348421
-
Alpha7-nicotinic acetylcholine receptors mediate an Abeta1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons
-
Fodero, L. R., Mok, S. S., Losic, D., Martin, L. L., Aguilar, M. I., Barrow, C. J., Livett, B. G., and Small, D. H. (2004) Alpha7-nicotinic acetylcholine receptors mediate an Abeta1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons. J. Neurochem. 88, 1186-1193.
-
(2004)
J. Neurochem.
, vol.88
, pp. 1186-1193
-
-
Fodero, L.R.1
Mok, S.S.2
Losic, D.3
Martin, L.L.4
Aguilar, M.I.5
Barrow, C.J.6
Livett, B.G.7
Small, D.H.8
-
26
-
-
15044344417
-
Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease
-
in press
-
Small, D. H., Fodero, L. R., Losic, D., Chu, C., Aguilar, M. I., Martin, L. L., and Chebib, M. (2004) Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease. Lett. Pept. Sci. (in press).
-
(2004)
Lett. Pept. Sci.
-
-
Small, D.H.1
Fodero, L.R.2
Losic, D.3
Chu, C.4
Aguilar, M.I.5
Martin, L.L.6
Chebib, M.7
|