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Volumn 56, Issue 4, 2004, Pages 203-208

Alzheimer's disease therapeutics: New approaches to an ageing problem

Author keywords

Alzheimer's disease; Amyloid; Cholesterol; Dementia; Immunotherapy; Nicotine; Secretase

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA AMYLOID ANTIBODY; BETA SECRETASE; BETA SECRETASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NICOTINIC AGENT; UNCLASSIFIED DRUG;

EID: 3042538415     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540410001709211     Document Type: Review
Times cited : (8)

References (26)
  • 1
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor, J. P., Hardy, J., and Fischbeck, K. H. (2002) Toxic proteins in neurodegenerative disease. Science 296, 1991-1995.
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 2
    • 0032814135 scopus 로고    scopus 로고
    • Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?
    • Small, D. H., and McLean, C. A. (1999) Alzheimer's disease and the amyloid beta protein: What is the role of amyloid? J. Neurochem. 73, 443-449.
    • (1999) J. Neurochem. , vol.73 , pp. 443-449
    • Small, D.H.1    McLean, C.A.2
  • 3
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870.
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6    Bird, T.D.7    Hardy, J.8    Hutton, M.9    Kukull, W.10
  • 4
    • 0035433962 scopus 로고    scopus 로고
    • Alzheimer's disease and Abeta toxicity: From top to bottom
    • Small, D. H., Mok, S. S., and Bornstein, J. C. (2001) Alzheimer's disease and Abeta toxicity: from top to bottom. Nat. Rev. Neurosci. 2, 595-598.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 595-598
    • Small, D.H.1    Mok, S.S.2    Bornstein, J.C.3
  • 5
    • 0036833437 scopus 로고    scopus 로고
    • Therapeutic strategies for Alzheimer's disease
    • Wolfe, M. S. (2002) Therapeutic strategies for Alzheimer's disease. Nat. Rev. Drug Dis. 1, 859-866.
    • (2002) Nat. Rev. Drug Dis. , vol.1 , pp. 859-866
    • Wolfe, M.S.1
  • 7
    • 0034797234 scopus 로고    scopus 로고
    • The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase
    • Nunan, J., Shearman, M. S., Checler, F., Cappai, R., Evin, G., Beyreuther, K., Masters, C. L., and Small, D. H. (2001) The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase. Eur. J. Biochem. 268, 5329-5336.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 5329-5336
    • Nunan, J.1    Shearman, M.S.2    Checler, F.3    Cappai, R.4    Evin, G.5    Beyreuther, K.6    Masters, C.L.7    Small, D.H.8
  • 8
    • 0242330370 scopus 로고    scopus 로고
    • Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: Effect of C-terminal truncation on production of beta-amyloid protein
    • Nunan, J., Williamson, N., Hill, A. F., Sernee, M. F., Masters, C. L., and Small, D. H. (2003) Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. J. Neurosci. Res. 74, 378-385.
    • (2003) J. Neurosci. Res. , vol.74 , pp. 378-385
    • Nunan, J.1    Williamson, N.2    Hill, A.F.3    Sernee, M.F.4    Masters, C.L.5    Small, D.H.6
  • 9
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-beta immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk, D. (2002) Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 3, 824-828.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 824-828
    • Schenk, D.1
  • 11
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., and Weller, R. O. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nature Med. 9, 448-452.
    • (2003) Nature Med. , vol.9 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 13
    • 0032773427 scopus 로고    scopus 로고
    • Amyloid and lipids in the pathology of Alzheimer disease
    • Roher, A. E., Kuo, Y. M., Kokjohn, K. M., Emmerling, M. R., and Gracon, S. (1999) Amyloid and lipids in the pathology of Alzheimer disease. Amyloid 6, 136-145.
    • (1999) Amyloid , vol.6 , pp. 136-145
    • Roher, A.E.1    Kuo, Y.M.2    Kokjohn, K.M.3    Emmerling, M.R.4    Gracon, S.5
  • 15
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G., and Siegel, G. (2000) Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57, 1439-1443.
    • (2000) Arch. Neurol. , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 18
    • 0037312139 scopus 로고    scopus 로고
    • Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes
    • Subasinghe, S., Unabia, S., Barrow, C. J., Mok, S. S., Aguilar, M. I., and Small, D. H. (2003) Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes. J. Neurochem. 84, 471-479.
    • (2003) J. Neurochem. , vol.84 , pp. 471-479
    • Subasinghe, S.1    Unabia, S.2    Barrow, C.J.3    Mok, S.S.4    Aguilar, M.I.5    Small, D.H.6
  • 19
    • 0027398069 scopus 로고
    • The diversity of neuronal nicotinic acetylcholine receptors
    • Sargent, P. B. (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16, 403-443.
    • (1993) Annu. Rev. Neurosci. , vol.16 , pp. 403-443
    • Sargent, P.B.1
  • 22
    • 0020083001 scopus 로고
    • Cigarette smoking and state-dependent memory
    • Peters, R., and McGee, R. (1982) Cigarette smoking and state-dependent memory. Psychopharmacology (Berl.) 76, 232-235.
    • (1982) Psychopharmacology (Berl.) , vol.76 , pp. 232-235
    • Peters, R.1    McGee, R.2
  • 23
    • 0032589578 scopus 로고    scopus 로고
    • The alpha7 nicotinic acetylcholine receptor in neuronal plasticity
    • Broide, R. S., and Leslie, F. M. (1999) The alpha7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 20, 1-16.
    • (1999) Mol. Neurobiol. , vol.20 , pp. 1-16
    • Broide, R.S.1    Leslie, F.M.2
  • 24
    • 0042357192 scopus 로고    scopus 로고
    • Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation
    • Wang, H. Y., Li, W., Benedetti, N. J., and Lee, D. H. (2003) Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation. J. Biol. Chem. 278, 31547-31553.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31547-31553
    • Wang, H.Y.1    Li, W.2    Benedetti, N.J.3    Lee, D.H.4
  • 25
    • 1442348421 scopus 로고    scopus 로고
    • Alpha7-nicotinic acetylcholine receptors mediate an Abeta1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons
    • Fodero, L. R., Mok, S. S., Losic, D., Martin, L. L., Aguilar, M. I., Barrow, C. J., Livett, B. G., and Small, D. H. (2004) Alpha7-nicotinic acetylcholine receptors mediate an Abeta1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons. J. Neurochem. 88, 1186-1193.
    • (2004) J. Neurochem. , vol.88 , pp. 1186-1193
    • Fodero, L.R.1    Mok, S.S.2    Losic, D.3    Martin, L.L.4    Aguilar, M.I.5    Barrow, C.J.6    Livett, B.G.7    Small, D.H.8
  • 26
    • 15044344417 scopus 로고    scopus 로고
    • Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease
    • in press
    • Small, D. H., Fodero, L. R., Losic, D., Chu, C., Aguilar, M. I., Martin, L. L., and Chebib, M. (2004) Role of Aβ and the α7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's disease. Lett. Pept. Sci. (in press).
    • (2004) Lett. Pept. Sci.
    • Small, D.H.1    Fodero, L.R.2    Losic, D.3    Chu, C.4    Aguilar, M.I.5    Martin, L.L.6    Chebib, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.