Trypsin and thrombin accelerate aggregation of human endocrine pancreas precursor cells

Journal of Cellular Physiology

Volumn 206, Issue 2, 2006, Pages 322-328

  Wei, Chiju ^a   Geras Raaka, Elizabeth ^a   Marcus Samuels, Bernice ^a   Oron, Yoram ^b   Gershengorn, Marvin C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLTYROSYLGLYCYLLYSYLPHENYLALANINAMIDE; CALCIUM ION; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 AGONIST; PROTEINASE ACTIVATED RECEPTOR 4; PROTEINASE ACTIVATED RECEPTOR 4 AGONIST; RHO FACTOR; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINAMIDE; SERYLPHENYLALANYLLEUCYLLEUCYLARGINYLASPARAGINAMIDE; THREONYLPHENYLALANYLLEUCYLLEUCYLARGININAMIDE; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM TRANSPORT; CELL AGGREGATION; FETUS CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS CARCINOMA; PANCREAS CELL; PANCREAS DUCT; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SECOND MESSENGER; SIGNAL TRANSDUCTION; STEM CELL;

CALCIUM; CELL AGGREGATION; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOPLASM; HUMANS; ISLETS OF LANGERHANS; OLIGOPEPTIDES; RECEPTORS, PROTEINASE-ACTIVATED; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; THROMBIN; TRYPSIN; TUMOR CELLS, CULTURED;

EID: 30344461929     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20459     Document Type: Article

References (29)

1. Abraham LA, Jenkins AL, Stone SR, Mackie EJ. 1998. Expression of the thrombin receptor in developing bone and associated tissues. J Bone Miner Res 13:818-827.
2. Alvarez C, Regan JP, Merianos D, Bass BL. 2004. Protease-activated receptor-2 regulates bicarbonate secretion by pancreatic duct cells in vitro. Surgery 136:669-676.
3. Chevessier F, Hantai D, Verdiere-Sahuque M. 2001. Expression of the thrombin receptor (PAR-1) during rat skeletal muscle differentiation. J Cell Physiol 189:152-161.
4. Clarke PGH. 1990. Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol 181:195-213.
5. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Jr, Coughlin SR. 1996. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381:516-519.
6. Coughlin SR. 2000. Thrombin signalling and protease-activated receptors. Nature 407:258-264.
7. Darrow AL, Fung-Leung WP, Ye RD, Santulli RJ, Cheung WM, Derian CK, Burns CL, Damiano BP, Zhou L, Keenan CM, Peterson PA, Andrade-Gordon P. 1996. Biological consequences of thrombin receptor deficiency in mice. Thromb Haemost 76:860-866.
8. Derian CK, Eckardt AJ, Andrade-Gordon P. 1997. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differ 8:743-749.
9. Edlund H. 2002. Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532.
10. Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM. 2004. Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306:2261-2264.
11. Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. 2001. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293:1666-1670.
12. Hardikar AA, Marcus-Samuels B, Geras-Raaka E, Raaka BM, Gershengorn MC. 2003. Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. Proc Natl Acad Sci USA 100:7117-7122.
13. Ikeda O, Egami H, Ishiko T, Ishikawa S, Kamohara H, Hidaka H, Mita S, Ogawa M. 2003. Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis. Int J Oncol 22:295-300.
14. Kawabata A. 2003. Gastrointestinal functions of proteinase-activated receptors. Life Sci 74:247-254.
15. Kawabata A, Kuroda R, Nishida M, Nagata N, Sakaguchi Y, Kawao N, Nishikawa H, Arizono N, Kawai K. 2002. Protease-activated receptor-2 (PAK-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci 71:2435-2446.
16. Macfarlane SR, Plevin R. 2003. Intracellular signalling by the G-protein coupled proteinase-activated receptor (PAH) family. Drug Dev Res 59:367-374.
17. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. 2001. Proteinase-activated receptors. Pharmacol Rev 53:245-282.
18. Mackie EJ, Pagel CN, Smith R, De Niese MR, Song SJ, Pike RN. 2002. Protease-activated receptors: A means of converting extracellular proteolysis into intracellular signals. IUBMB Life 53:277-281.
19. Naldini A, Sower L, Bocci V, Meyers B, Carney DH. 1998. Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation. J Cell Physiol 177:76-84.
20. Nguyen TD. 2004. Proteinase activated receptor 2: A protean effector comes of age. Gastroenterology 126:1907-1909.
21. Niclou SP, Suidan HS, Pavlik A, Vejsada R, Monard D. 1998. Changes in the expression of protease-activated receptor 1 and protease nexin-1 mRNA during rat nervous system development and after nerve lesion. Eur J Neurosci 10:1590-1607.
22. Ossovskaya VS, Bunnett NW. 2004. Protease-activated receptors: Contribution to physiology and disease. Physiol Rev 84:579-621.
23. 2+- independent action. Biochem J 216:287-294.
24. Rudroff C, Striegler S, Schilli M, Scheele J. 2001. Thrombin enhances adhesion in pancreatic cancer in vitro through the activation of the thrombin receptor PAR 1. Eur J Surg Oncol 27:472-476.
25. Rudroff C, Seibold S, Kaufmann R, Zetina CC, Reise K, Schafer U, Schneider A, Brockmann M, Scheele J, Neugebauer EA. 2002. Expression of the thrombin receptor PAR-1 correlates with tumour cell differentiation of pancreatic adenocarcinoma in vitro. Clin Exp Metastasis 19:181-189.
26. Soifer SJ, Peters KG, O'Keefe J, Coughlin SR. 1994. Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol 144:60-69.
27. Tran T, Stewart AG. 2003. Protease-activated receptor (PAH)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle. Br J Pharmacol 138:865-875.
28. Vergnolle N. 2000. Review article: Proteinase-activated receptors-novel signals for gastrointestinal pathophysiology. Aliment Pharmacol Ther 14:257-266.
29. Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC. 1998. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 95:6642-6646.