Proteinase activated receptor 2: A protean effector comes of age

Gastroenterology

Volumn 126, Issue 7, 2004, Pages 1907-1909

  Nguyen, Toan D ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Puget Sound VA Health Care System   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2;

CELL SECRETION; DIGESTIVE FUNCTION; EDITORIAL; FIBROSIS; GASTROINTESTINAL DISEASE; INFLAMMATION; NEUROMODULATION; NOMENCLATURE; PANCREATITIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SMOOTH MUSCLE CONTRACTILITY;

EID: 2942588964     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.04.026     Document Type: Editorial

References (24)

1. Déry O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 1998;274:C1429-C1452.
2. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A 1994;91:9208-9212.
3. Alm A-K, Gagnemo-Persson R, Sorsa T, Sundelin J. Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2. Biochem Biophys Res Comm 2000;275:77-83.
4. Cottrell GS, Amadesi S, Grady EF, Bunnett NW. Trypsin IV: a novel agonist of protease-activated receptors 2 and 4. J Biol Chem 2004; In Press.
5. Camerer E, Huang W, Coughlin SR. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A 2000;97:5255-5260.
6. D'Andrea M, Derian C, Leturcq D, Baker S, Brunmark A, Ling P, Darrow A, Santulli R, Brass L, Andrade-Gordon P. Characterization of protease activated receptor-2 immunoreactivity in normal human tissues. J Histochem Cytochem 1998;46:157-164.
7. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh D-S, Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 1999;103:261-269.
8. Danahay H, Withey L, Poll CT, Van De Graaf SFJ, Bridges RJ. Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells. Am J Physiol Cell Physiol 2001;280:C1455-C1464.
9. Bertog M, Letz B, Kong W, Steinhoff M, Higgins MA, Bielfeld-Ackermann A, Frömter E, Bunnett NW, Korbmacher C. Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. J Physiol 1999;521:3-17.
10. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD. A protective role for protease-activated receptors in the airways. Nature (London) 1999;398:156-160.
11. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6:151-158.
12. Figini M, Emanueli C, Grady EF, Kirkwood K, Payan DG, Ansel J, Gerard C, Geppetti P, Bunnett N. Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. Am J Physiol 1997;272:G785-G793.
13. Kawabata A, Kinoshita M, Nishikawa H, Kuroda R, Nishida M, Araki H, Arizono N, Oda Y, Kakehi K. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J Clin Invest 2001;107:1443-1450.
14. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 2001;7:821-826.
15. Hoogerwerf WA, Zou L, Shenoy M, Sun D, Micci MA, Lee-Hellmich H, Xiao SY, Winston JH, Pasricha PJ. The proteinase-activated receptor 2 is involved in nociception. J Neurosci 2001;21:9036-9042.
16. Compton SJ, Cairns JA, Holgate ST, Walls AF. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression. J Immunol 1998;161:1939-1946.
17. Fiorucci S, Mencarelll A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A 2001;98:13936-13941.
18. Frungieri MB, Weidinger S, Meineke V, Kohn FM, Mayerhofer A. Proliferative action of mast-cell tryptase is mediated by PAR-2, COX-2, prostaglandins, and PPARγ: possible relevance to human fibrotic disorders. Proc Natl Acad Sci U S A 2002;99:15072-15077.
19. Namkung W, Han W, Luo X, Muallem S, Cho KH, Kim KH, Lee MG. Protease-activated receptor 2 exerts local protection and mediates part of systemic complications in acute pancreatitis. Gastroenterology 2004;126:1844-1859.
20. Singh VP, Saluja AK, Navina S, Bhagat L, Andrade-Gordon P, Steer ML. PAR-2 plays a protective role in pancreatitis. Gastroenterology 2003;124(Suppl. 1):A-94.
21. Akers IA, Parsons M, Hill MR, Hollenberg MD, Sanjar S, Laurent GJ, McAnulty RJ. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am J Physiol 2000;278:L193-L201.
22. Schwab D, Raithel M, Hahn EG. Evidence for mast cell activation in collagenous colitis. Inflamm Res 1998;47(Suppl. 1):S64-S65.
23. Gelbmann CM, Mestermann S, Gross V, Köllinger M, Schölmerich J, Falk W. Strictures in Crohn's disease are characterized by an accumulation of mast cells colocalised with laminin but not with fibronectin or vitronectin. Gut 1999;45:210-217.
24. Matsunaga Y, Kawasaki H, Terada T. Stromal mast cells and nerve fibers in various chronic liver diseases: relevance to hepatic fibrosis. Am J Gastroenterol 1999;94:1923-1932.