In vitro and in vivo effects of deoxynivalenol (DNV) on regulators of cap dependent translation control in porcine endometrium

Reproductive Toxicology

Volumn 21, Issue 1, 2006, Pages 60-73

  Wollenhaupt, K ^a   Danicke S ^b   Brussow K P ^a   Tiemann, U ^a  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b INSTITUTE FOR EPIDEMIOLOGY AND PATHOGEN DIAGNOSTICS   (Germany)

Author keywords

In vitro and in vivo effects; Mycotoxin DNV; Pig endometrium; Translational control

Indexed keywords

D 0156; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; VOMITOXIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION; SWINE; TOXICITY;

ANIMALS; CELLS, CULTURED; DIET; ENDOMETRIUM; EUKARYOTIC INITIATION FACTOR-4E; FEMALE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SWINE; TRICHOTHECENES; TRITICUM; TUBULIN;

ANIMALIA; EUKARYOTA; SUIDAE; SUS SCROFA;

EID: 30044451139     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2005.06.003     Document Type: Article

References (61)

1. J.F. Grove Non-macrocyclic trichothecenes Nat Prod Rep 5 1988 187 209
2. J.F. Grove Macrocyclic trichothecenes Nat Prod Rep 10 1993 429 448
3. B.A. Rotter, D.B. Prelusky, and J.J. Pestka Toxicology of deoxynivalenol (vomitoxin) J Toxicol Environ Health 48 1996 1 34
4. W.L. Thompson, and R.W. Wannemacher Jr. Structure-function relationship of 12,13-epoxytrichothecene mycotoxins in cell culture: comparison to whole animal lethality Toxicon 24 1986 985 994
5. V.I. Shifrin, and P. Anderson Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis J Biol Chem 274 1999 13985 13992
6. G.S. Bondy, and J.J. Pestka Immunomodulation by fungal toxins J Toxicol Environ Health B Crit Rev 3 2000 109 143
7. S.H. Hussein, and J.M. Brasel Toxicity, metabolism, and impact of mycotoxins on humans and animals Toxicology 167 2001 101 134
8. U. Tiemann, T. Viergutz, L. Jonas, and F. Schneider Influence of the mycotoxins α- and β-zearalenol and deoxynivalenol on the cell cycle of cultured porcine endometrial cells Reprod Toxicol 17 2003 209 218
9. J.L. Middlebrook, and D.L. Leatherman Binding of T-2 toxin to eukaryotic cell ribosomes Biochem Pharmacol 38 1989 3103 3110
10. M.F. Witt, and J.J. Pestka Uptake of the naturally occurring 3-α-hydroxy isomer of T-2 toxin by a murine B-cell hybridoma Food Chem Toxicol 28 1990 21 28
11. S. Dänicke Fusariumtoxine in der Tierernährung Großtierpraxis 3 2002 5 18
12. M.S. Iordanov, D. Pribnow, J.L. Magun, T.H. Dihn, J.A. Pearson, and S.L. Chen Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA Mol Cell Biol 17 1997 3373 3381
13. M.H. Cobb MAP kinase pathways Prog Biophys Mol Biol 71 1999 479 500
14. C. Dong, R.J. Davis, and R.A. Flavell MAP kinases in the immune response Annu Rev Immunol 20 2002 55 72
15. T.G. Boulton, S.H. Nye, D.J. Robbins, N.Y. Ip, E. Radziejewska, and S.D. Morgenbesser ERKs: a family of protein-serine/threonine kinases that are activated and tyrosin phosphorylated in response to insulin and NGF Cell 65 1991 663 675
16. A.L. Cahill, and R.L. Perlman Activation of a microtubule-associated protein-2 kinase by insulin-like growth factor-1 in bovine chromaffin cells J Neurochem 57 1991 1832 1839
17. G. Pages, P. Lenormand, G. L'Allemain, J.C. Chambare, S. Meloche, and J. Pouyssegur Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation Proc Natl Acad Sci USA 90 1993 8319 8323
18. Y. Moon, and J.J. Pestka Vomitoxin-induced cyclooxygenase-2 gene expression in macrophages mediated by activation of ERK and p38 but not JNK mitogen-activated protein kinases Toxicol Sci 69 2002 373 382
19. H.R. Zhou, Z. Islam, and J.J. Pestka Rapid sequential activation of mitogen-activated protein kinases and transcription factors precedes proinflammatory cytokine mRNA expression in spleens of mice exposed to the trichothecene vomitoxin (deoxynivalenol) Toxicol Sci 72 2003 130 142
20. C.Y. Chen, and A.B. Shyu AU-rich elements: characterization and importance in mRNA degradation Trends Biochem Sci 20 1995 465 470
21. W. Zhang, B.J. Wagner, K. Ehrenman, A.W. Schaefer, C.T. DeMaria, and D. Crater Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1 Mol Cell Biol 13 1993 7652 7665
22. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
23. T. Zhu, and P.E. Lobie Janus kinase 2-dependent activation of p38 mitogen-activated protein kinase by growth hormone. Resultant transcriptional activation of ATF-2 and CHOP, cytoskeletal re-organization and mitogenesis J Biol Chem 275 2000 2103 2114
24. S.K. Moon, B.Y. Cha, and C.H. Kim ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappa B and AP-1: involvement of the ras dependent pathway J Cell Physiol 198 2004 417 427
25. R. Winzen, G. Gowrishankar, F. Bollig, K. Resch, and H. Holtmann Distinct domains of AU-rich elements exert different function in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR Mol Cell Biol 24 2004 4835 4847
26. T.P. Herbert, R.A. Tee, and C.G. Proud The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites J Biol Chem 277 2002 11591 11596
27. N. Sonenberg Cap-binding proteins of eucaryotic mRNA: function in initiation and control of translation Microbiol Rev 44 1988 173 225
28. N. Sonenberg, and A.C. Gingras The mRNA 5′ cap-binding protein eIF4E and control of cell growth Curr Opin Cell Biol 10 1998 268 275
29. G.C. Scheper, B. van Kollenburg, J. Hu, Y. Luo, D.J. Goss, and C.G. Proud Phosphorylation of eukaryotic initiation factor 4E markedly reduced its affinity for capped mRNA J Biol Chem 277 2002 3303 3309
30. S. Pyronnet, H. Imataka, A.C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E. EMBO J 18 1999 270 279
31. X. Wang, A. Flynn, A.J. Waskiewicz, B.L.J. Webb, R.G. Vries, and I.A. Baines The phosphorylation of eucaryotic initiation factor eIF4E in response to phorbol esters, cell stresses and cytokines is mediated by distinct MAP kinase pathways J Biol Chem 273 1998 9373 9377
32. C. Tschopp, U. Knauf, M. Brauchle, M. Zurini, P. Ramage, and D. Glueck Phosphorylation of eIF4E on series 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies Mol Cell Biol Res Commun 3 2000 205 211
33. S.J. Morley, and L. McKendrick Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signalling pathways in the enhanced phosphorylation of initiation factor eIF4E in NIH 3T3 cells J Biol Chem 272 1997 17887 17893
34. A. Pause, G.J. Belshem, A.C. Gingras, O. Donze, T.A. Lin, and J.R. Lawrence Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function Nature 371 1994 762 767
35. W. Tomek, F.A. Mela Sterza, M. Kubelka, K. Wollenhaupt, H. Torner, and M. Anger Regulation of translation during in vitro maturation of bovine oocytes: the role of MAP kinase, eIF4E (cap binding protein) phosphorylation, and eIF4E-BP1 Biol Reprod 66 2002 1274 1282
36. U. Tiemann, F. Schneider, and A. Tuchscherer Effects of organochloride pesticides on synthesis of cultured oviductal and uterine cells and on estrogen receptor of uterine tissue from heifers Arch Toxicol 70 1996 490 496
37. U. Tiemann, T. Viergutz, L. Jonas, K. Wollenhaupt, R. Pöhland, and W. Kanitz Fluorometric detection of platelet activating factor receptor in cultured oviductal epithelial and stromal cells and endometrial stromal cells from bovine at different stages of the oestrous cycle and early pregnancy Dom Anim Endocrinol 20 2001 149 164
38. Y. Bertois, J.A. Katzenellenbogen, and B.S. Katzenellenbogen Phenol red was omitted from the medium in all experiments to avoid possible interference by this substances with the steroid receptor Proc Natl Acad Sci USA 83 1986 2496 2500
39. BML 2000: The German Federal Ministry of Agriculture and Forestry (BML): orientation values for critical concentrations of deoxynivalenol and zearalenone in the diets for pigs, ruminants and gallinaceous poultry, 6 October 2003.
40. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein dye binding Anal Biochem 72 1976 248 254
41. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 275
42. H. Towbin, T. Staehlin, and J. Gordon Electrophoretic transfer of proteins from acrylamide gels to nitrocellulose sheets. Proc Natl Acad Sci USA 76 1979 4350 4354
43. K. Wollenhaupt, L. Jonas, U. Tiemann, and W. Tomek Influence of the mycotoxin α- and β-zearalenol (ZOL) on regulators of cap-dependent translation control in pig endometrial cells Reprod Toxicol 19 2004 189 199
44. S. Pyronnet, and N. Sonenberg Cell-cycle-dependent translational control Curr Opin Genet Dev 11 2001 13 18
45. G.C. Scheper, N.A. Moricce, and C.G. Proud The MAP kinase signal-integrating konase Mnk2 is an eIF4E kinase with high basal activity in mammalian cells Mol Cell Biol 21 2001 743 754
46. Y. Moon, and J.J. Pestka Deoxynivalenol-induced mitogen-activated protein kinase phosphorylation and IL-6 expression in mice suppressed by fish oil J Nutrit Biochem 14 2003 717 726
47. Cashel M, Rudd K. In: Neidhardt F, Ingraham J, Low K, Magasanik B, Schaechter M, Umbarger H, editors. Escherichia coli and Salmonella typhimurium: cellular and molecular biology, 2. Washington, DC: American Society for Microbiology; 1987. p. 1410-38.
48. B.M. Marte, and Downward J PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond Trends Biochem Sci 22 1997 355 358
49. R.N. Kolesnick, and M. Kronke Regulation of ceramide production and apoptosis Annu Rev Physiol 60 1998 643 665
50. J. Massague' G1 cell-cycle control and cancer Nature 432 2004 298 306
51. B.M. Burgering, and P.J. Coffer Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction Nature 376 1995 599 602
52. D. Stokoe, L.R. Stephens, T. Copeland, P.R. Gaffney, C.B. Reese, and G.F. Painter Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B Science 277 1997 567 570
53. D.R. Alessi, S.R. James, C.P. Downes, A.B. Holmes, P.R. Gaffney, and C.B. Reese Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr Biol 7 1997 261 269
54. M.J. Rane, P.Y. Coxon, D.W. Powell, R. Webster, J.B. Klein, and W. Pierce P38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide- dependent kinase-2 for Akt in human neutrophils J Biol Chem 276 2001 3517 3523
55. J. Hayakawa, M. Ohmichi, H. Kurachi, Y. Kanda, K. Hisamoto, and Y. Nishio Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitises human ovarian cancer cells to cisplatin Cancer Res 60 2000 5988 5994
56. S.G. Kennedy, A.J. Wagner, S.D. Conzen, J. Jordan, A. Bellacosa, and P.N. Tsichlis The PI3-kinase/Akt signalling pathway delivers an anti-apoptotic signal Genes Dev 11 1997 701 713
57. M.M. Karim, J.M. Hughes, J. Warwicker, G.C. Scheper, C.G. Proud, and J.E. Mc-Carthy A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1 J Biol Chem 276 2001 20750 20757
58. M. Schuh Klinische Auswirkungen der in Österreich vorkommenden Mykotoxine Wiener tierärztl Monatsschrift 68 1981 308 311
59. I. Oswald, S. Bouket, D.E. Marin, P. Pinton, and I. Tatanu Auswirkungen von Mykotoxinen auf das Immunsystem von Schweinen Großtierpraxis 4 2003 5 10
60. D. Yan, H.R. Zhou, K.H. Brooks, and J.J. Pestka Role of macrophages in elevated IgA and IL-6 production by peyer's patch cultures following acute oral vomitoxin exposure Toxicol Appl Pharmacol 148 1998 261 273
61. R.L. Warner, K. Brooks, and J.J. Pesta In vitro effects of vomitoxin (deoxynivalenol) on T-cell interleukin production and IgA secretion Food Chem Toxicol 32 1994 617 625