The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins

Glycoconjugate Journal

Volumn 19, Issue 1, 2003, Pages 13-21

  López Ferrer, Anna ^a   De Bolós, Carme ^a  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

Author keywords

Apomucin glycosylation; Fucosyltransferases; MUC1; MUC5AC

Indexed keywords

ALPHA 1,2 FUCOSE; ANTIGEN; APOMUCIN DERIVATIVE; COMPLEMENTARY DNA; FUCOSE; FUCOSYLTRANSFERASE; LEWIS ANTIGEN 1; LEWIS ANTIGEN 2; MUCIN 1; MUCIN 5AC; MUCIN 6; PROTEIN FUT1; PROTEIN FUT2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL SPECIFICITY; CELL TYPE; COLON CANCER; CONTROLLED STUDY; DNA TRANSFECTION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPOTHESIS; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; STOMACH EPITHELIUM;

ANIMALS; CA-15-3 ANTIGEN; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FLOW CYTOMETRY; FUCOSYLTRANSFERASES; GENE EXPRESSION; GLYCOSYLATION; HUMANS; LEWIS BLOOD-GROUP SYSTEM; MICE; MUCINS; NEOPLASM TRANSPLANTATION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0242668793     PISSN: 02820080     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022576712961     Document Type: Article

References (67)

1. Gendler SJ, Spicer AP, Epithelial mucin genes, Ann Rev Physiol 57, 607-34 (1995).
2. Lesuffleur T, Zweibaum A, Real FX, Mucins in normal and neoplastic human gastrointestinal tissues, Crit Rev Oncol 17, 153-80 (1994).
3. Bobek LA, Tsai H, Biesbrock AR, Levine MJ, Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7), J Biol Chem 268, 20563-9 (1993).
4. Shankar V, Gilmore MS, Elkins RC, Sachdev GP, A novel human airway mucin cDNA encodes a protein with unique tandem- repeat organization, Biochem J 300 (Pt 2), 295-8 (1994).
5. Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM, Two novel mucin genes down-regulated in colorectal cancer identified by differential display, Cancer Res 59, 4083-9 (1999).
6. Ho SB, Niehans GA, Lyftogt C, Yah PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS, Heterogeneity of mucin gene expression in normal and neoplastic tissues, Cancer Res 53, 641-51 (1993).
7. Carrato C, Balague C, de Bolos C, Gonzalez E, Gambus G, Planas J, Perini JM, Andreu D, Real FX, Differential apomucin expression in normal and neoplastic human gastrointestinal tissues, Gastroenterology 107, 160-72 (1994).
8. Kontani K, Taguchi O, Narita T, Izawa M, Hiraiwa N, Zenita K, Takeuchi T, Murai H, Miura S, Kannagi R, Modulation of MUC1 mucin as an escape mechanism of breast cancer cells from autologous cytotoxic T-lymphocytes, Br J Cancer 84, 1258-64 (2001).
9. Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simoes M, Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma, Int J Cancer 79, 402-10 (1998).
10. Gerken TA, Butenhof KJ, Shogren R, Effects of glycosylation on the conformation and dynamics of O-linked glycoproteins: Carbon-13 NMR studies of ovine submaxillary mucin, Biochemistry 28, 5536-43 (1989).
11. Yin BW, Finstad CL, Kitamura K, Federici MG, Welshinger M, Kudryashov V, Hoskins WJ, Welt S, Lloyd KO, Serological and immunochemical analysis of Lewis y (Ley) blood group antigen expression in epithelial ovarian cancer, Int J Cancer 65, 406-12 (1996).
12. Suwa T, Hinoda Y, Makiguchi Y, Takahashi T, Itoh F, Adachi M, Hareyama M, Imai K, Increased invasiveness of MUC1 and cDNA-transfected human gastric cancer MKN74 cells, Int J Cancer 76, 377-82 (1998).
13. Satoh S, Hinoda Y, Hayashi T, Burdick MD, Imai K, Hollingsworth MA, Enhancement of metastatic properties of pancreatic cancer cells by MUC1 gene encoding an anti-adhesion molecule, Int J Cancer 88, 507-18 (2000).
14. Larsen RD, Ernst LK, Nair RP, Lowe JB, Molecular cloning, sequence, and expression of a human GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen, Proc Natl Acad Sci USA 87, 6674-8 (1990).
15. Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB, Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype, J Biol Chem 270, 4640-9 (1995).
16. Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB, A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase, Genes Dev 4, 1288-303 (1990).
17. Lowe JB, Kukowska-Latallo JF, Nair RP, Larsen RD, Marks RM, Macher BA, Kelly RJ, Ernst LK, Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion, J Biol Chem 266, 17467-77 (1991).
18. Weston BW, Nair RP, Larsen RD, Lowe JB, Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities, J Biol Chem 267, 4152-60 (1992).
19. Weston BW, Smith PL, Kelly RJ, Lowe JB, Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes, J Biol Chem 267, 24575-84 (1992).
20. Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T, Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes, J Biol Chem 269, 14730-7 (1994).
21. Varki A, Biological roles of oligosaccharides: All of the theories are correct, Glycobiology 3, 97-130 (1993).
22. Hakomori S, New directions in cancer therapy based on aberrant expression of glycosphingolipids: Anti-adhesion and orthosignaling therapy, Cancer Cells 3, 461-70 (1991).
23. Garrigues J, Anderson J, Hellstrom KE, Hellstrom I, Anti-tumor antibody BR96 blocks cell migration and binds to a lysosomal membrane glycoprotein on cell surface microspikes and ruffled membranes, J Cell Biol 125, 129-42 (1994).
24. Goupille C, Hallouin F, Meflah K, Le Pendu J, Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfection, Glycobiology 7, 221-9 (1997).
25. Boren T, Falk P, Roth KA, Larson G, Normark S, Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens, Science 262, 1892-5 (1993).
26. Chan NW, Stangier K, Sherburne R, Taylor DE, Zhang Y, Dovichi NJ, Palcic MM, The biosynthesis of Lewis X in Helicobacter pylori, Glycobiology 5, 683-8 (1995).
27. Aspinall GO, Monteiro MA, Lipopolysaccharides of Helicobacter pylori strains P466 and MO19: Structures of the O antigen and core oligosaccharide regions, Biochemistry 35, 2498-504 (1996).
28. Aspinall GO, Monteiro MA, Pang H, Walsh EJ, Moran AP, Lipopolysaccharide of the Helicobacter pylori type strain NCTC 11637 (ATCC 43504): Structure of the O antigen chain and core oligosaccharide regions, Biochemistry 35, 2489-97 (1996).
29. Ge Z, Chan NW, Palcic MM, Taylor DE, Cloning and heterologous expression of an alpha1,3-fucosyltransferase gene from the gastric pathogen Helicobacter pylori, J Biol Chem 272, 21357-63 (1997).
30. Monteiro MA, Chan KH, Rasko DA, Taylor DE, Zheng PY, Appelmelk BJ, Wirth HP, Yang M, Blaser MJ, Hynes SO, Moran AP, Perry MB, Simultaneous expression of type 1 and type 2 Lewis blood group antigens by Helicobacter pylori lipopolysaccharides. Molecular mimicry between h. pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms, J Biol Chem 273, 11533-43 (1998).
31. de Bolos C, Garrido M, Real FX, MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach, Gastroenterology 109, 723-34 (1995).
32. Lopez-Ferrer A, de Bolos C, Barranco C, Garrido M, Isern J, Carlstedt I, Reis CA, Torrado J, Real FX, Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium, Gut 47, 349-56 (2000).
33. de Bolos C, Real FX, Lopez-Ferrer A, Regulation of mucin and glycoconjugate expression: From normal epithelium to gastric tumors, Front Biosci 6, D1256-63 (2001).
34. Lesuffleur T, Kornowski A, Augeron C, Dussaulx E, Barbat A, Laboisse C, Zweibaum A, Increased growth adaptability to 5-fluorouracil and methotrexate of HT- 29 sub-populations selected for their commitment to differentiation, Int J Cancer 49, 731-7 (1991).
35. Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB, Molecular basis for H blood group deficiency in Bombay (Oh) and paraBombay individuals, Proc Natl Acad Sci USA 91, 5843-7 (1994).
36. Price MR, Edwards S, Owainati A, Bullock JE, Ferry B, Robbins RA, Baldwin RW, Multiple epitopes on a human breast-carcinoma-associated antigen, Int J Cancer 36, 567-74 (1985).
37. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Simoes M, Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody, Int J Cancer 74, 112-21 (1997).
38. Sakamoto J, Furukawa K, Cordón-Cardo C, Yin BW, Rettig WJ, Oettgen HF, Old LJ, Lloyd KO, Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines, Cancer Res 46, 1553-61 (1986).
39. Xing PX, Reynolds K, Tjandra JJ, Tang XL, McKenzie IF, Synthetic peptides reactive with anti-human milk fat globule membrane monoclonal antibodies, Cancer Res 50, 89-96 (1990).
40. Rouger P, Gane P Salmon C, Tissue distribution of H, Lewis and P antigens as shown by a panel of 18 monoclonal antibodies, Rev Fr Transfus Immunohematol 30, 699-708 (1987).
41. Pastan I, Lovelace ET, Gallo MG, Rutherford AV, Magnani JL, Willingham MC, Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas, Cancer Res 51, 3781-7 (1991).
42. Hovenberg HW, Davies JR, Carlstedt I, Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells, Biochem J 318 (Pt 1), 319-24 (1996).
43. Pratt WS, Islam I, Swallow DM, Two additional polymorphisms within the hypervariable MUC1 gene: Association of alleles either side of the VNTR region, Ann Hum Genet 60 (Pt 1), 21-8 (1996).
44. Van Klinken BJ, Dekker J, Buller HA, de Bolos C, Einerhand AW, Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract, Am J Physiol 273, G296-302 (1997).
45. Silverman HS, Parry S, Sutton-Smith M, Burdick MD, McDermott K, Reid CJ, Batra SK, Morris HR, Hollingsworth MA, Dell A, Harris A, In vivo glycosylation of mucin tandem repeats, Glycobiology 11, 459-71 (2001).
46. Axelsson MA, Karlsson NG, Steel DM, Ouwendijk J, Nilsson T, Hansson GC, Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins, Glycobiology 11, 633-44 (2001).
47. Lloyd KO, Burchell J, Kudryashov V, Yin BW, Taylor-Papadimitriou J, Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines. Demonstration of simpler and fewer glycan chains in tumor cells, J Biol Chem 271, 33325-34 (1996).
48. Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, Clausen H, Burchell JM, Taylor-Papadimitriou J, The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1, J Biol Chem 276, 11007-15 (2001).
49. Tetaert D, Ten Hagen KG, Richet C, Boersma A, Gagnon J, Degand P, Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUCSAC mucin motif peptides, Biochem J 357, 313-20 (2001).
50. Tetaert D, Richet C, Gagnon J, Boersma A, Degand P, Studies of acceptor site specificities for three members of UDP-GalNAc:N-acetylgalactosaminyltransferases by using a synthetic peptide mimicking the tandem repeat of MUC5AC, Carbohydr Res 333, 165-71 (2001).
51. Wesseling J, van der Valk SW, Vos HL, Sonnenberg A, Hilkens J, Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components, J Cell Biol 129, 255-65 (1995).
52. Zhang K, Baeckstrom D, Brevinge H, Hansson GC, Secreted MUC1 mucins lacking their cytoplasmic part and carrying sialylLewis a and x epitopes from a tumor cell line and sera of colon carcinoma patients can inhibit HL-60 leukocyte adhesion to E-selectin- expressing endothelial cells, J Cell Biochem 60, 538-49 (1996).
53. Regimbald LH, Pilarski LM, Longenecker BM, Reddish MA, Zimmermann G, Hugh JC, The breast mucin MUCI as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer, Cancer Res 56, 4244-9 (1996).
54. Wesseling J, van der Valk SW, Hilkens J, A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1, Mol Biol Cell 7, 565-77 (1996).
55. Van Klinken BJ, Einerhand AW, Buller HA, Dekker J, The oligomerization of a family of four genetically clustered human gastrointestinal mucins, Glycobiology 8, 67-75 (1998).
56. Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P, Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa, Science 241, 705-8 (1988).
57. Newton JL, Allen A, Westley BR, May FE, The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach, Gut 46, 312-20 (2000).
58. Tomasetto C, Masson R, Linares JL, Wending C, Lefebvre O, Chenard MP, Rio MC, pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins, Gastroenterology 118, 70-80 (2000).
59. Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, Bellocq JP, Chambon P, Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract, Gastroenterology 100, 375-9 (1991).
60. Wright NA, Poulsom R, Stamp G, Van Norden S, Sarraf C, Elia G, Ahnen D, Jeffery R, Longcroft J, Pike C, et al., Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease, Scand J Gastroenterol Suppl 193, 76-82 (1992).
61. Lefebvre O, Wolf C, Kedinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC, The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression, J Cell Biol 122, 191-8 (1993).
62. Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wending C, Tomasetto C, Chambon P, Rio MC, Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein, Science 274, 259-62 (1996).
63. Van den Brink GR, Tytgat KM, Van der Hulst RW, Van der Loos CM, Einerhand AW, Buller HA, Dekker J, H pylori colocalises with MUC5AC in the human stomach, Gut 46, 601-7 (2000).
64. Sepp A, Skacel P, Lindstedt R, Lechler RI, Expression of alpha-1,3-galactose and other type 2 oligosaccharide structures in a porcine endothelial cell line transfected with human alpha-1,2-fucosyltransferase cDNA, J Biol Chem 272, 23104-10 (1997).
65. Sharma A, Okabe J, Birch P, McClellan SB, Martin MJ, Platt JL, Logan JS, Reduction in the level of Gal(alpha 1,3)Gal in transgenic mice and pigs by the expression of an alpha(1,2)fucosyltransferase, Proc Natl Acad Sci USA 93, 7190-5 (1996).
66. Majuri ML, Niemela R, Tiisala S, Renkonen O, Renkonen R, Expression and function of alpha 2,3-sialyl- and alpha 1,3/1,4-fucosyltransferases in colon adenocarcinoma cell lines: Role in synthesis of E-selectin counter-receptors, Int J Cancer 63, 551-9 (1995).
67. Gouyer V, Leteurtre E, Delmotte P, Steelant WF, Krzewinski-Recchi MA, Zanetta JP, Lesuffleur T, Trugnan G, Delannoy P, Huet G, Differential effect of GalNAcalpha-O-bn on intracellular trafficking in enterocytic HT-29 and Caco-2 cells: Correlation with the glycosyltransferase expression pattern, J Cell Sci 114, 1455-71 (2001).