DC-SIGN-specific liposomal targeting and selective intracellular compound delivery to human myeloid dendritic cells: Implications for HIV disease

Scandinavian Journal of Immunology

Volumn 59, Issue 5, 2004, Pages 415-424

  Gieseler, R K ^a,b   Marquitan, G ^a   Hahn, M J ^a   Perdon, L A ^a   Driessen, W H P ^b   Sullivan, S M ^a,b   Scolaro, M J ^a  

^a LTBH Medical Research Institute   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCEIN; CD209 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD83 ANTIGEN; IMMUNOLIPOSOME; LECTIN; LIPOSOME; T6 ANTIGEN;

ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG TARGETING; DRUG UPTAKE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL MODEL; NORMAL HUMAN; PRIORITY JOURNAL; VIRUS TRANSMISSION;

CELL ADHESION MOLECULES; CELLS, CULTURED; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; FLUORESCEINS; HIV INFECTIONS; HUMANS; LECTINS, C-TYPE; LIPOSOMES; MICROSCOPY, FLUORESCENCE; MYELOID CELLS; PILOT PROJECTS; RECEPTORS, CELL SURFACE;

EID: 2642534487     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0300-9475.2004.01431.x     Document Type: Article

References (52)

1. Gieseler RKH, Röber RA, Kuhn R, Weber K, Osborn M, Peters JH. Dendritic accessory cells derived from rat bone marrow precursors under chemically defined conditions in vitro belong to the myeloid lineage. Eur J Cell Biol 1991;54:171-81.
2. Peters JH, Gieseler R, Thiele B, Steinbach F. Dendritic cells: from ontogenetic orphans to myelomonocytic descendants. Immunol Today 1996;17:273-8.
3. Banchereau J, Paczesny S, Blanco P et al. Dendritic cells: controllers of the immune system and a new promise for immunotherapy. Ann N Y Acad Sci 2003;987:180-7.
4. Schuler G, Schuler-Thurner B, Steinman RM. The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003;15:138-47.
5. Cranmer LD, Trevor KT, Hersh EM. Clinical applications of dendritic cell vaccination in the treatment of cancer. Cancer Immunol Immunother 2003;26:26.
6. Schrager LK, D'Souza MP. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. JAMA 1998;280:67-71.
7. Gieseler RK, Marquitan G, Scolaro MJ, Cohen MD. Lessons from history: dysfunctional APCs, inherent dangers of STI and an important goal, as yet unmet. Trends Immunol 2003;24:11.
8. UNAIDS. Global summary of the HIV/AIDS epidemic: December 2003. (available from http://www.unaids.org/wad/2003/press/epiupdate2003_en/epi03- 02_en.htm).
9. Snedecor SJ. Comparison of three kinetic models of HIV-1 infection: implications for optimization of treatment. J Theor Biol 2003;221:519-41.
10. Hwang K. Liposome pharmacokinetics. In: Liposomes: From Biophysics to Therapeutics. MJ Ostro ed. New York: Marcel Dekker, 1987: 109-56.
11. Bethune C, Blum A, Geyer JR, Silber JR, Ho RJY. Lipid association increases the potency against primary medulloblastoma cells and systemic exposure of 1-(2-chloroerhyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats. Pharm Res 1999;16:896-903.
12. Sullivan SM, Gieseler RK, Lenzner S et al. Inhibition of human immunodeficiency virus-1 proliferation by liposome-encapsulated sense DNA to the 5′-tat splice acceptor site. Antisense Res Dev 1992;2:187-97.
13. Leserman LD, Barbet J, Kourilsky F, Weinstein JN. Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A. Nature 1980;288:602-4.
14. Geijtenbeek TBH, Torensma R, van Vliet SJ et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000;100:575-85.
15. Geijtenbeek TBH, Kwon DS, Torensma R et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances transinfection of T cells. Cell 2000;100:587-97.
16. Soilleux EJ, Morris LS, Leslie G et al. Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol 2002;71:445-57.
17. Geijtenbeek TBH, Groot PC, Nolte MA et al. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood 2002;100:2908-16.
18. Soilleux EJ, Morris LS, Lee B et al. Placental expression of DC-SIGN may mediate intrauterine vertical transmission of HIV. J Pathol 2001;195:586-92.
19. Soilleux EJ, Coleman N. Transplacental transmission of HIV: a potential role for HIV binding lectins. Int J Biochem Cell Biol 2003;35:283-7.
20. Kämmerer U, Eggert AO, Kapp M et al. Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. Am J Pathol 2003;162:887-96.
21. Geijtenbeek TBH, van Kooyk Y. DC-SIGN: a novel HIV receptor on DCs that mediates HIV-1 transmission. Curr Top Microbiol Immunol 2003;276:31-54.
22. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langer-hans cells. Nature 1992;360:258-61.
23. Peters JH, Xu H, Ruppert J, Ostermeier D, Friedrichs D, Gieseler RKH. Signals required for differentiating dendritic cells from human monocytes in vitro. Adv Exp Med Biol 1993;329:275-80.
24. Ruppert J, Schütt C, Ostermeier D, Peters JH. Down-regulation and release of CD14 on human monocytes by IL-4 depends on the presence of serum or GM-CSF. Adv Exp Med Biol 1993;329:281-6.
25. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994;179:1109-18.
26. + dendritic cells. Proc Natl Acad Sci USA 1996;93:2588-92.
27. Gieseler R, Heise D, Soruri A, Schwartz P, Peters JH. In-vitro differentiation of mature dendritic cells from human blood monocytes. Dev Immunol 1998;6:25-39.
28. Steinman RM, Granelli-Piperno A, Pope M et al. The interaction of immunodeficiency viruses with dendritic cells. Curr Top Microbiol Immunol 2003;276:1-30.
29. McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 2003;300:1295-7.
30. Turville SG, Santos JJ, Frank I et al. Immunodeficiency virus uptake, turnover, and two-phase transfer in human dendritic cells. Blood 2003, (online publication ahead of print: DOI 2003, 10.1182/blood-2003-09-3129).
31. Reeves JP, Buck D, Berkower I, Murphy D, Epstein SL. Anti-Leu3a induces combining site-related anti-idiotypic antibody without inducing anti-HIV activity. AIDS Res Hum Retroviruses 1991;7:55-63.
32. Teunissen MBM. Dynamic nature and function of epidermal Langerhans cells in vivo and in vitro: a review, with emphasis on human Langerhans cells. Histochem J 1992;24:697-716.
33. Yrlid U, Macpherson G. Phenotype and function of rat dendritic cell subsets. APMIS 2003;111:756-65.
34. Jahnsen FL, Gran E, Haye R, Brandtzaeg P. Human nasal mucosa contains antigen-presenting cells of strikingly different functional phenotypes. Am J Respir Cell Mol Biol 2004;30:31-7. (DOI.10.1165/rcmb.2002-0230OC).
35. Allen TM, Hansen C, Martin F, Redemann C, Yau-Young A. Liposomes containing synthetic lipid derivatives of poly (ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1991;1066:29-36.
36. Gabizon A. Liposome circulation time and tumor targeting: implications for cancer chemotherapy. Adv Drug Deliv Rev 1995;16:285-94.
37. Dufresne I, Désormeaux A, Bestman-Smith J, Gourde P, Tremblay MJ, Bergeron MG. Targeting lymph nodes with liposomes bearing anti-HLA-DR Fab′ fragments. Biochim Biophys Acta 1999;1421:284-94.
38. Bestman-Smith J, Gourde P, Désormeaux A, Tremblay MJ, Bergeron MG. Sterically stabilized liposomes bearing anti-HLA-DR antibodies for targeting the primary cellular reservoirs of HIV-1. Biochim Biophys Acta 2000;1468:161-74.
39. Bestman-Smith J, Désormeaux A, Tremblay MJ, Bergeron MG. Targeting cell-free HIV and virally-infected cells with anti-HLA-DR immunoliposomes containing amphotericin B. AIDS 2000;14:2457-65.
40. Gagné JF, Désormeaux A, Perron S, Tremblay MJ, Bergeron MG. Targeted delivery of indinavir to HIV-1 primary reservoirs with immunoliposomes. Biochim Biophys Acta 2002;1558:198-210.
41. Engering A, Geijtenbeek TBH, van Vliet SJ et al. The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol 2002;168:2118-26.
42. Kwon DS, Gregorio G, Bitton N, Hendrickson WA, Littman DR. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity 2002;16:135-44.
43. Cambi A, Gijzen K, de Vries JM et al. The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol 2003;33:532-8.
44. Colmenares M, Puig-Kroger A, Pello OM, Corbi AL, Rivas L. Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes. J Biol Chem 2002;277:36766-9.
45. 287-infected macaques. J Acquir Immune Defic Syndr 2003;34:387-97.
46. Schjetne KW, Thompson KM, Aarvak T, Fleckenstein B, Sollid LM, Bogen B. A mouse Cκ-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation. Int Immunol 2002;14:1423-30.
47. Baribaud F, Pöhlmann S, Leslie G, Mortari F, Doms RW. Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells. J Virol 2002;76:9135-42.
48. Frank I, Piatak M, Stoessel H et al. Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs. J Virol 2002;76:2936-51.
49. Downing I, Koch C, Kilpatrick DC. Immature dendritic cells possess a sugar-sensitive receptor for human mannan-binding lectin. Immunology 2003;109:360-4.
50. Spear GT, Zariffard MR, Xin J, Saifuddin M. Inhibition of DC-SIGN-mediated trans infection of T cells by mannose-binding lectin. Immunology 2003;110:80-5.
51. Serre K, Giraudo L, Henri S, Machy P, Leserman L. Dendritic cells capture and efficiently present antigen encapsulated in liposomes to T cells in vivo. Liposome Res 2003;13:21-3.
52. Soruri A, Fayyazi A, Gieseler R et al. Specific: autologous anti-melanoma T cell response in vitro using monocyte-derived dendritic cells. Immunobiology 1998;198:527-38.