Gene and stem cell therapy for erectile dysfunction

International Journal of Impotence Research

Volumn 17, Issue SUPPL. S1, 2005, Pages

  Deng, W ^a   Bivalacqua, T J ^b   Hellstrom, W J G ^a   Kadowitz, P J ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Adeno associated virus; Adenovirus; Calcitonin gene related peptide; Endothelial nitric oxide synthase; Erectile dysfunction; Gene therapy; RhoA Rho kinase; Stem cells; Superoxide dismutase

Indexed keywords

ADENOVIRUS VECTOR; CALCITONIN GENE RELATED PEPTIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HERPESVIRUS VECTOR; PARVOVIRUS VECTOR; RHO KINASE; SILDENAFIL; SUPEROXIDE DISMUTASE; ZAPRINAST;

CAVERNOUS SINUS; CELL BASED GENE THERAPY; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CYTOMEGALOVIRUS; DIABETES MELLITUS; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; GENE EXPRESSION; GENE TRANSFER; HUMAN; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; GENE THERAPY; IMPOTENCE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NITRIC OXIDE SYNTHASE TYPE III; RHOA GTP-BINDING PROTEIN; STEM CELLS; SUPEROXIDE DISMUTASE;

EID: 30044446099     PISSN: 09559930     EISSN: 14765489     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901430     Document Type: Review

References (70)

1. Shabsigh R, Anastasiadis AG. Erectile dysfunction. Annu Rev Med 2003; 54: 153-168.
2. Rajfer J et al. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326: 90-94.
3. Cellek S. Let's make NO mistake!. Int J Impot Res 2005; 17: 388-389.
4. Burnett AL et al. Nitric oxide: a physiologic mediator of penile erection. Science 1992; 257: 401-403.
5. Toda N, Ayajiki K, Okamura T. Nitric oxide and penile erectile function. Pharmacol Ther 2005; 106: 233-266.
6. Giuliano F, Rampin O. Neural control of erection. Physiol Behav 2004; 83: 189-201.
7. Nehra A et al. Third International Conference on the Management of Erectile Dysfunction: Linking Pathophysiology and Therapeutic Response. J Urol 2003; 170: S3-S5.
8. Rosen RC. Psychogenic erectile dysfunction. Classification and management. Urol Clin North Am 2001; 28: 269-278.
9. Seftel AD, Sun P, Swindle R. The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction. J Urol 2004; 171: 2341-2345.
10. Rendell MS, Rajfer J, Wicker PA, Smith MD. Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA 1999; 281: 421-426.
11. Martinez-Jabaloyas JM et al. Prognostic factors for response to Sildenafil in patients with erectile dysfunction. Eur Urol 2001; 40: 641-646.
12. Shabsigh R. Therapy of ED: PDE-5 Inhibitors. Endocrine 2004; 23: 135-141.
13. Setter SM et al. Phosphodiesterase 5 inhibitors for erectile dysfunction. Ann Pharmacother 2005; 39: 1286-1295.
14. Gonzalez-Cadavid NF, Ignarro LJ, Rajfer J. Nitric Oxide and the Cyclic GMP System in the Penis. Mol Urol 1999; 3: 51-59.
15. Garban H et al. Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol 1995; 268: 467-475.
16. Matz RL, Andriantsitohaina R. Age-related endothelial dysfunction: potential implications for pharmacotherapy. Drugs Aging 2003; 20: 527-550.
17. Champion HC et al. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proc Natl Acad Sci USA 1999; 96: 11648-11652.
18. Bivalacqua TJ et al. Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. Int J Impot Res 2000; 12(Suppl 3): S8-S17.
19. Saenz de Tejada I et al. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989; 320: 1025-1030.
20. Bloomgarden ZT. American Diabetes Association Annual Meeting, 1997. Endothelial dysfunction, neuropathy and the diabetic foot, diabetic mastopathy, and erectile dysfunction. Diabetes Care 1998; 21: 183-189.
21. Lue TF. Erectile dysfunction. N Engl J Med 2000; 342: 1802-1813.
22. Steger RW et al. Streptozotocin-induced deficits in sex behavior and neuroendocrine function in male rats. Endocrinology 1989; 124: 1737-1743.
23. Bivalacqua TJ et al. Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats. J Urol 2003; 169: 1911-1917.
24. Bivalacqua TJ et al. Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats. Int J Impot Res 2004; 16: 21-29.
25. Brain SD et al. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985; 313: 54-56.
26. Lippton HL et al. Vasodilator activity of human alpha-calcitonin gene-related peptide in the feline mesenteric vascular bed. Am J Hypertens 1988; 1: 124S-126S.
27. Champion HC et al. Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model. J Androl 1997; 18: 513-521.
28. Champion HC et al. In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse. Circulation 2000; 101: 923-930.
29. Chattergoon NN et al. Antiproliferative effects of calcitonin gene-related peptide in aortic and pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2005; 288: L202-L211.
30. van Rossum D, Hanisch UK, Quirion R. Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. Neurosci Biobehav Rev 1997; 21: 649-678.
31. Hirata Y et al. Calcitonin gene-related peptide receptor in cultured vascular smooth muscle and endothelial cells. Biochem Biophys Res Commun 1988; 151: 1113-1121.
32. de Hoon JN et al. Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans. Clin Pharmacol Ther 2003; 73: 312-321.
33. Qing X, Keith IM. Targeted blocking of gene expression for CGRP receptors elevates pulmonary artery pressure in hypoxic rats. Am J Physiol Lung Cell Mol Physiol 2003; 285: L86-L96.
34. Hay DL et al. The pharmacology of CGRP-responsive receptors in cultured and transfected cells. Peptides 2004; 25: 2019-2026.
35. Stief CG, Wetterauer U, Schaebsdau FH, Jonas U. Calcitonin gene-related peptide: a possible role in human penile erection and its therapeutic application in impotent patients. J Urol 1991; 146: 1010-1014.
36. Wimalawansa SJ. Age-related changes in tissue contents of immunoreactive calcitonin gene-related peptide. Aging (Milano) 1992; 4: 211-217.
37. + channels in CGRP-induced dilatation of basilar artery in vivo. Am J Physiol 1993; 265: H581-H585.
38. 1 in the treatment of erectile dysfunction. J Urol 1993; 149: 1296-1298.
39. Bivalacqua TJ et al. Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat. Biol Reprod 2001; 65: 1371-1377.
40. Jeremy JY et al. Platelets, oxidant stress and erectile dysfunction: an hypothesis. Cardiovasc Res 2000; 46: 50-54.
41. Jones RW et al. Oxygen free radicals and the penis. Expert Opin Pharmacother 2002; 3: 889-897.
42. Bivalacqua TJ et al. Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats. Am J Physiol Heart Circ Physiol 2003; 284: H1408-H1421.
43. Azadzoi KM, Schulman RN, Aviram M, Siroky MB. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol 2005; 174: 386-393.
44. Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986; 320: 454-456.
45. Fukai T, Folz RJ, Landmesser U, Harrison DG. Extracellular superoxide dismutase and cardiovascular disease. Cardiovasc Res 2002; 55: 239-249.
46. Beckman JS et al. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-1624.
47. Squadrito GL, Pryor WA. Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic Biol Med 1998; 25: 392-403.
48. Stralin P, Karlsson K, Johansson BO, Marklund SL. The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. Arterioscler Thromb Vasc Biol 1995; 15: 2032-2036.
49. Marklund SL. Human copper-containing superoxide dismutase of high molecular weight. Proc Natl Acad Sci USA 1982; 79: 7634-7638.
50. Levin ED. Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging. Curr Alzheimer Res 2005; 2: 191-196.
51. Chacko S, Conti MA, Adelstein RS. Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2+ regulation. Proc Natl Acad Sci USA 1977; 74: 129-133.
52. Mills TM et al. Vasoconstriction, RhoA/Rho-kinase and the erectile response. Int J Impot Res 2003; 15(Suppl 5): S20-S24.
53. Feng J et al. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 1999; 274: 37385-37390.
54. Gong MC et al. Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II. Am J Physiol Cell Physiol 2001; 281: C257-C269.
55. Chitaley K et al. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001; 7: 119-122.
56. Rees RW et al. Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol 2001; 133: 455-458.
57. Chang S et al. Increased contractility of diabetic rabbit corpora smooth muscle in response to endothelin is mediated via Rho-kinase beta. Int J Impot Res 2003; 15: 53-62.
58. Bivalacqua TJ et al. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2004; 101: 9121-9126.
59. Knorr D. Serious Event on NIH Human Gene Transfer Protocol 9512-139. A Phase I Study of Adenovector-Mediated Gene Transfer to Liver in Adults With Partial Ornithine Transcarbamylase Deficiency. Bethesda, MD: memorandum, National Institutes of Health, Office of Recombinant DNA Activities, 21 September 1999.
60. Brenner M. Gene transfer by adenovectors. Blood 1999; 94: 3965-3967.
61. Friedenstein AJ et al. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 1974; 17: 331-340.
62. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-74.
63. Ferrari G et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998; 279: 1528-1530.
64. Pittenger MF et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-147.
65. Deng W, Obrocka M, Fischer I, Prockop DJ. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun 2001; 282: 148-152.
66. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001; 19: 180-192.
67. Kassem M. Mesenchymal stem cells: biological characteristics and potential clinical applications. Cloning Stem Cells 2004; 6: 369-374.
68. Deng W et al. Adenoviral gene transfer of eNOS: high-level expression in ex vivo expanded marrow stromal cells. Am J Physiol Cell Physiol 2003; 285: C1322-C1329.
69. Deng W et al. Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector. Stem Cells 2004; 22: 1279-1291.
70. Bivalacqua TJ et al. Gene therapy techniques for the delivery of endothelial nitric oxide synthase to the corpora cavernosa for erectile dysfunction. In: Aviv Hassid (ed). Nitric Oxide Protocols. Humana Press: Totowa, 2004, pp 173-186.