Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells

Biochemical and Biophysical Research Communications

Volumn 307, Issue 4, 2003, Pages 1008-1012

  Hu, Bo ^a   Li, Dayuan ^a   Sawamura, Tatsuya ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Endothelial cells; LDL receptor; LOX 1; Ox LDL; Superoxide anions

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; COMPLEMENTARY RNA; LECTIN LIKE RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; RECEPTOR; RECEPTOR ANTIBODY; SUPEROXIDE; TROLOX C; UNCLASSIFIED DRUG;

ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY; DOWN REGULATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TIME;

EID: 0038105318     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01295-6     Document Type: Article

References (22)

1. Steinberg D., Witztum J.L. Lipoproteins and atherogenesis. JAMA. 264:1990;3047-3052.
2. Jialal I., Devaraj S. The role of ox-LDL in atherogenesis. J. Nutr. 126:1996;S1053-S1057.
3. Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science. 232:1986;34-47.
4. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
5. Li D., Mehta J.L. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implication in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler. Thromb. Vasc. Biol. 20:2000;1116-1122.
6. Chen H., Li D., Sawamura T., Inoue K., Mehta J.L. Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan. Biochem. Biophys. Res. Commun. 276:2000;1100-1104.
7. Li D.Y., Chen H.J., Staples E.D., Ozaki K., Annex B., Singh B.K., Vermani R., Mehta J.L. Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions. J. Cardiovasc. Pharmacol. Ther. 7:2002;147-153.
8. Draude G., Hrboticky N., Lorenz R.L. The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin. Biochem. Pharmacol. 57:1999;383-386.
9. Kume N., Moriwaki H., Kataoka H., Minami M., Murase T., Sawamura T., Masaki T., Kita T. Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells. Ann. N Y Acad. Sci. 902:2000;323-327.
10. Mehta J.L., Li D.Y. Identification and autoregulation of receptor for ox-LDL in cultured human coronary artery endothelial cells. Biochem. Biophys. Res. Commun. 248:1998;511-514.
11. Li D.Y., Zhang Y.C., Philips M.I., Sawamura T., Mehta J.L. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotension II type I receptor activation. Circ. Res. 84:1999;1043-1049.
12. Murase T., Kume N., Korenaga R., Ando J., Sawamura T., Masaki T., Kita T. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor- I in vascular endothelial cells. Circ. Res. 83:1998;329-333.
13. Kume N., Murase T., Moriwaki H., Aoyama T., Sawamura T., Masaki T., Kita T. Inducible expression of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in vascular endothelial cells. Circ. Res. 83:1998;322-327.
14. Cominacini L., Pasini A.F., Garbin U., Davoli A., Tosetti M.L., Campagnola M., Rigoni A., Pastorino A.M., Lo Cascio V., Sawamura T. Oxidized low-density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J. Biol. Chem. 275:2000;12633-12638.
15. Chen H., Li D., Saldeen T., Mehta J.L. Transforming growth factor-beta(1) modulates oxidatively modified LDL-induced expression of adhesion molecules: role of LOX-1. Circ. Res. 89:2001;155-160.
16. Li D., Mehta J.L. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation. 101:2000;2889-2895.
17. Saldeen T., Li D.Y., Mehta J.L. Differential effects of α- and γ-tocopherol on low-density lipoprotein oxidation superoxide activity, platelet aggregation, and arterial thrombogenesis. J. Am. Coll. Cardiol. 34:1999;1208-1215.
18. Tsukamoto K., Kinoshita M., Kojima K., Mikuni Y., Kudo M., Mori M., Fujita M., Horie E., Shimazu N., Teramoto T. Synergically increased expression of CD36, CLA-1, and CD68, but not of SR-A and LOX-1, with the progression to foam cells from macrophages. J. Atheroscler. Thromb. 9:2002;57-64.
19. Boullier A., Bird D.A., Chang M.K., Dennis E.A., Friedman P., Gillotre-Taylor K., Horkko S., Palinski W., Quehenberger O., Shaw P., Steinberg D., Terpstra V., Witztum J.L. Scavenger receptors oxidized LDL, and atherosclerosis. Ann. N Y Acad. Sci. 947:2001;214-222. discussion 222-223.
20. Vergnani L., Hatrik S., Ricci F., Passaro A., Manzoli N., Zuliani G., Brovkovych V., Fellin R., Malinski T. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation. 101:2000;1261-1266.
21. Li D.Y., Yang B.C., Mehta J.L. Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am. J. Physiol. 275:1999;H568-H576.
22. Chen L., Haught W.H., Yang B., Saldeen T.G., Parathasarathy S., Mehta J.L. Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of anti-atherosclerotic effects of vitamin E, lovastatin and amlodipine. J. Am. Coll. Cardiol. 30:1997;569-575.