Increased density but not prevalence of gametocytes following drug treatment of Plasmodium falciparum

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 100, Issue 2, 2006, Pages 176-183

  Ali, Eltayeb ^a   Mackinnon, Margaret J ^b   Abdel Muhsin, Abdel Muhsin A ^c   Ahmed, Salah ^d   Walliker, David ^b   Babiker, Hamza A ^b,e  

^a SUDAN ATOMIC ENERGY COMMISSION   (Sudan)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c TROPICAL MEDICINE RESEARCH INSTITUTE   (Sudan)

^d UNIVERSITY OF KHARTOUM   (Sudan)

^e SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Chloroquine; Drug resistance; Gametocytogenesis; Plasmodium falciparum; RT PCR; Sudan; Sulfadoxine pyrimethamine

Indexed keywords

CHLOROQUINE; DIHYDROFOLATE REDUCTASE; FANSIDAR; MULTIDRUG RESISTANCE PROTEIN 1; PROTOZOAL PROTEIN; PYRIMETHAMINE;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CELL DENSITY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SENSITIVITY; GAMETOCYTE; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PREVALENCE; PROTEIN EXPRESSION; PROTOZOAL GENETICS; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; SUDAN; THERAPY RESISTANCE;

ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; CHILD; CHLOROQUINE; DRUG COMBINATIONS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MIDDLE AGED; PLASMODIUM FALCIPARUM; PREVALENCE; PYRIMETHAMINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUDAN; SULFADOXINE;

PLASMODIUM FALCIPARUM;

EID: 29744451313     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2005.04.021     Document Type: Article

References (40)

1. A.A. Adbel-Muhsin L.C. Ranford-Cartwright A.R. Medani S. Ahmed S. Suleiman B. Khan P. Hunt D. Walliker H.A. Babiker Detection of mutations in the Plasmodium falciparum dihydrofolate reductase (dhfr) gene by dot-blot hybridization Am. J. Trop. Med. Hyg. 67 2002 24-27
2. A.A. Abdel-Muhsin M.J. Mackinnon E. Ali el-K.A. Nassir S. Suleiman S. Ahmed D. Walliker H.A. Babiker Evolution of drug resistance genes in Plasmodium falciparum in an area of seasonal transmission in Eastern Sudan J. Infect. Dis. 189 2004 1239-1244
3. M. Alifrangis S. Enosse I.F. Khalil D.S. Tarimo M.M. Lemnge R. Thompson I.C. Bygbjerg A.M. Ronn Prediction of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: A comparative study between sites of differing endemicity Am. J. Trop. Med. Hyg. 69 2003 601-606
4. H.A. Babiker D. Walliker Author reply to: Levels of chloroquine resistance in Plasmodium falciparum are determined by loci other than pfcrt and pfmdr1 J. Infect. Dis. 185 2002 406-407
5. H.A. Babiker A.M. Creasey R.A. Bayoumi D. Walliker D.E. Arnot Genetic diversity of Plasmodium falciparum in a village in eastern Sudan. 2. Drug resistance, molecular karyotypes and the mdr1 genotype in recent isolates Trans. R. Soc. Trop. Med. Hyg. 85 1991 578-583
6. H.A. Babiker J. Lines W.G. Hill D. Walliker Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa Am. J. Trop. Med. Hyg. 56 1997 141-147
7. H.A. Babiker A. Abdel-Wahab S. Ahmed S. Suleiman L.C. Ranford-Cartwright R. Carter D. Walliker Detection of low level Plasmodium falciparum gametocytes using reverse transcriptase polymerase chain reaction Mol. Biochem. Parasitol. 99 1999 143-148
8. H.A. Babiker G. Satti H.M. Ferguson R. Bayoumi D. Walliker Drug resistant Plasmodium falciparum in an area of seasonal transmission Acta Trop. 94 2005 260-268
9. R.A. Bayoumi H.A. Babiker S.M. Ibrahim H.W. Ghalib B.O. Saeed S. Khider M. Elwasila E.A. Karim Chloroquine-resistant Plasmodium falciparum in eastern Sudan Acta Trop. 46 1989 157-165
10. A.G. Buckling L.H. Taylor J.M. Carlton A.F. Read Adaptive changes in Plasmodium falciparum transmission strategies following chloroquine chemotherapy Proc. Biol. Sci. 264 1997 553-559
11. A. Buckling L.C. Ranford-Cartwright A. Miles A.F. Read Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro Parasitology 118 1999 339-346
12. J. Curtis M.T. Duraisingh D.C. Warhurst In vivo selection for specific genotype of dihydropteroate synthase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chloroproguanil-dapsone treatment J. Infect. Dis. 177 1998 1429-1433
13. A. Djimde O.K. Doumbo J.F. Cortese K. Kayentao S. Doumbo Y. Diourte A. Dicko X.-Z. Su T. Nomura D.A. Fidock T.E. Wellems C.V. Plowe D. Coulibaly A molecular marker for chloroquine-resistant falciparum malaria N. Engl. J. Med. 344 2001 257-263
14. M.T. Duraisingh L. von Seidlein A. Jepson P. Lones I. Sambou M. Pinder D.C. Warhurst Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum Parasitology 121 2000 1-7
15. J.M. Edwards J.J. Moulds W.J. Judd Chloroquine dissociation of antigen-antibody complexes. A new technique for typing red blood cells with a positive direct antiglobulin test Transfusion 22 1982 59-61
16. D.A. Fidock T. Nomura A.K. Talley R.A. Cooper S.M. Dzekunov M.T. Ferdig L.M. Ursos A.B. Sidhu B. Naude K.W. Deitsch X.Z. Su J.C. Wootton P.D. Roepe T.E. Wellems Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance Mol. Cell 6 2000 861-871
17. A.A. Hamad A. el H. Nugud D.E. Arnot A.A. Abdel-Muhsin G.M. Satti T.G. Theander A.M. Creasey H.A. Babiker D.E. Elnaiem A marked seasonality of malaria transmission in two rural sites in eastern Sudan Acta Trop. 83 2002 71-82
18. S.M. Handunnetti D.M. Gunewardena P.P. Pathirana K. Ekanayake S. Weerasinghe K.N. Mendis Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control Trans. R. Soc. Trop. Med. Hyg. 90 1996 563-567
19. F. Hawking M.E. Wilson K. Gammage Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum Trans. R. Soc. Trop. Med. Hyg. 65 1971 549-559
20. B. Hogh A. Gamage-Mendis G.A. Butcher R. Thompson K. Begtrup C. Mendis S.M. Enosse M. Dgedge J. Barreto W. Eling R.E. Sinden The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector Am. J. Trop. Med. Hyg. 58 1998 176-182
21. M.E. Ibrahim F.M. Awad-el-Kariem I.M. el Hassan E.R. el Mubarak A case of Plasmodium falciparum malaria sensitive to chloroquine but resistant to pyrimethamine/sulfadoxine in Sennar, Sudan Trans. R. Soc. Trop. Med. Hyg. 85 1991 446
22. J.G. Kublin F.K. Dzinjalamala D.D. Kamwendo E.M. Malkin J.F. Cortese L.M. Martino R.A. Mukadam S.J. Rogerson A.G. Lescano M.E. Molyneux P.A. Winstanley P. Chimpeni T.E. Taylor C.V. Plowe Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria J. Infect. Dis. 185 2002 380-388
23. J.D. Lines T.J. Wilkes E.O. Lyimo Human malaria infectiousness measured by age-specific sporozoite rates in Anopheles gambiae in Tanzania Parasitology 102 1991 167-177
24. M.J. Mackinnon I.M. Hastings The evolution of multiple drug resistance in malaria parasites Trans. R. Soc. Trop. Med. Hyg. 92 1998 188-195
25. F. Méndez A. Muñoz G. Carrasquilla D. Jurado M. Arévalo-Herrera J.F. Cortese C. Plowe Determinants of treatment response to sulfadoxine-pyrimethamine and subsequent transmission potential in falciparum malaria Am. J. Epidemiol. 156 2002 230-238
26. M. Menegon C. Severini A. Sannella M.G. Paglia D. Sangare A. Abdel-Wahab A.A. Abdel-Muhsin H. Babiker D. Walliker P. Alano Genotyping of Plasmodium falciparum gametocytes by reverse transcriptase polymerase chain reaction Mol. Biochem. Parasitol. 111 2000 153-161
27. T.S. Naotunne N.D. Karunaweera G. Del Giudice M.U. Kularatne G.E. Grau R. Carter K.N. Mendis Cytokines kill malaria parasites during infection crisis: Extracellular complementary factors are essential J. Exp. Med. 173 1991 523-529
28. E. Nassir A.M. Abdel-Muhsin S. Suliaman F. Kenyon A. Kheir H. Geha H.M. Ferguson D. Walliker H.A. Babiker Impact of genetic complexity on longevity and gametocytogenesis of Plasmodium falciparum during the dry and transmission-free season of eastern Sudan Int. J. Parasitol. 35 2005 49-55
29. V. Novell I.T. El-Toham V.M. Osundw F. Ashong A.J.G. Barclay J.B.S. Coulter Floods and resistant malaria Lancet 332 1988 1367
30. D.S. Peterson D. Walliker T.E. Wellems Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria Proc. Natl. Acad. Sci. USA 85 1988 9114-9118
31. C.V. Plowe A. Djimde M. Bouare O. Doumbo T.E. Wellems Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: Polymerase chain reaction methods for surveillance in Africa Am. J. Trop. Med. Hyg. 52 1995 565-568
32. M.B. Reed K.J. Saliba S.R. Caruana K. Kirk A.F. Cowman Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum Nature 403 2000 906-909
33. V. Robert H.P. Awono-Ambene J.Y. Le Hesran J.F. Trape Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine. Am. J. Trop. Med. Hyg. 62 2000 210-216
34. A. Sowunmi B.A. Fateye Plasmodium falciparum gametocytaemia in Nigerian children: Before, during and after treatment with antimalarial drugs Trop. Med. Int. Health 8 2003 783-792
35. C.J. Sutherland A. Alloueche J. Curtis C.J. Drakeley R. Ord M. Duraisingh B.M. Greenwood M. Pinder D. Warhurst G.A. Targett Gambian children successfully treated with chloroquine can harbour and transmit Plasmodium falciparum gametocytes carrying resistance genes Am. J. Trop. Med. Hyg. 67 2002 578-585
36. G. Targett C. Drakeley M. Jawara L. von Seidlein R. Coleman J. Deen M. Pinder T. Doherty C. Sutherland G. Walraven P. Milligan Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae J. Infect. Dis. 183 2001 1254-1259
37. L.H. Taylor A.F. Read Why so few transmission stages? Reproductive restraint by malaria parasites Parasitol. Today 13 1997 135-140
38. T. Tchuinkam B. Mulder K. Dechering H. Stoffels J.P. Verhave M. Cot P. Carnevale J.H. Meuwissen V. Robert Experimental infections of Anopheles gambiae with Plasmodium falciparum of naturally infected gametocyte carriers in Cameroon: Factors influencing the infectivity to mosquitoes Trop. Med. Parasitol. 44 1993 271-276
39. J.F. Trape The public health impact of chloroquine resistance in Africa Am. J. Trop. Med. Hyg. 64 2001 12-17
40. T.E. Wellems C.V. Plowe Chloroquine-resistant malaria J. Infect. Dis. 184 2001 770-776