Determinants of treatment response to sulfadoxine-pyrimethamine and subsequent transmission potential in falciparum malaria

American Journal of Epidemiology

Volumn 156, Issue 3, 2002, Pages 230-238

  Méndez, Fabián ^a,b   Muñoz, Álvaro ^c   Carrasquilla, Gabriel ^b,d   Jurado, Diana ^b   Arévalo Herrera, Myriam ^b   Cortese, Joseph F ^e   Plowe, Christopher V ^e,f  

^a Secretaria Departamental Salud Valle   (Colombia)

^b UNIVERSIDAD DEL VALLE   (Colombia)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d Division Salud   (Colombia)

^e UNIVERSITY OF MARYLAND   (United States)

^f University of Maryland School of Medicine Center for Vaccine Development   (United States)

Author keywords

Dihydropteroate synthase; Drug resistance; Malaria; Plasmodium falciparum; Pyrimethamine; Sulfadoxine

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; FANSIDAR;

DISEASE CONTROL; DISEASE PREVALENCE; DRUG PRESCRIBING; HEALTH CARE; MALARIA;

ARTICLE; CLEARANCE; COLOMBIA; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; GAMETOCYTE; GENE MUTATION; HUMAN; LIVER FAILURE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NUTRITIONAL STATUS; PARASITE SURVIVAL; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PREDICTION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; DIHYDROPTEROATE SYNTHASE; DRUG COMBINATIONS; DRUG RESISTANCE; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; MUTATION; PARASITEMIA; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; SULFADOXINE; TETRAHYDROFOLATE DEHYDROGENASE; TREATMENT OUTCOME;

COLOMBIA;

EID: 0036681854     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/kwf030     Document Type: Article

References (28)

1. Malaria as a reemerging disease
2. The epidemiology and control of malaria
3. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of sulfadoxine-pyrimethamine use and resistance
4. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria
5. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodiumfalciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance
6. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine
7. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine
8. Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum
9. P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: Epidemiology and role in clinical resistance to antifolates
10. Molecular basis of in vivo resistance to sulfadoxine-pyrimethamine in African adult patients infected with Plasmodium falciparum malaria parasites
11. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodiumfalciparum: Genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites
12. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria
13. Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria
14. Severe and complicated malaria
15. A molecular marker for chloroquine-resistant falciparum malaria
16. Iron
17. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: A double-blind, randomized, controlled trial
18. Molecular assays for surveillance of antifolate-resistant malaria
19. Folate antagonists and mechanisms of resistance
20. Predictors of mefloquine treatment failure: A prospective study of 1590 patients with uncomplicated falciparum malaria
21. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections
22. Antimalarial drugs and the mosquito transmission of Plasmodium
23. Studies of efficacy of treatment with sulfamethoxazole + trimethropim and sulfalene + pyrimethamine combinations in Plasmodium falciparum malaria of known and unknown resistant status
24. Evidence for environmental modulation in Plasmodium falciparum in continuous culture
25. Commitment to gametocytogenesis in Plasmodium falciparum
26. Fallibility in estimating direct effects