Plasmodium falciparum gametocytaemia in Nigerian children: Before, during and after treatment with antimalarial drugs

Tropical Medicine and International Health

Volumn 8, Issue 9, 2003, Pages 783-792

  Sowunmi, A ^a,b   Fateye, B A ^a,b  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Antimalarial drugs; Children; Gametocytaemia; Gametocyte rate; Nigeria; Plasmodium falciparum

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; CHLOROQUINE; CHLORPHENIRAMINE; FANSIDAR; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOTIFEN; PARACETAMOL;

CHILD; DISEASE TREATMENT; DRUG PRESCRIBING; MALARIA;

ADOLESCENT; ARTICLE; CELL DENSITY; CHILD; CLEARANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FOLLOW UP; GAMETOCYTE; HALF LIFE TIME; HUMAN; IN VIVO STUDY; INFANT; KINETICS; MAJOR CLINICAL STUDY; MALARIA; MALARIA FALCIPARUM; MALE; MONOTHERAPY; NIGERIA; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

AGE FACTORS; AMODIAQUINE; ANIMALS; ANTIMALARIALS; CHILD; CHILD, PRESCHOOL; CHLOROQUINE; DRUG COMBINATIONS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; NIGERIA; PARASITEMIA; PLASMODIUM FALCIPARUM; PYRIMETHAMINE; SULFADOXINE;

NIGERIA;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0042736858     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2003.01093.x     Document Type: Article

References (29)

1. Eichner M, Diebner HH, Molineaux L, Collins WE, Jeffery GM & Dietz K (2001) Genesis, sequestration and survival of Plasmodium falciparum gametocytes: parameter estimates from fitting a model to malariotherapy data. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 497-501.
2. Ekanem OJ, Weisfeld JS, Salako LA et al. (1990) Sensitivity of Plasmodium falciparum to chloroquine and sulphadoxine-pyrimethamine in Nigerian children. Bulletin of the World Health Organization 68, 45-52.
3. Falade CO, Salako LA, Sowunmi A, Oduola AMJ & Larcier P (1997) Comparative efficacy of halofantrine, chloroquine and sulphadoxine-pyrimethamine in the treatment of acute uncomplicated falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 91, 58-62.
4. Handunnetti SM, Gunewardena DM, Pathirana PPSL, Ekanayake K, Weerasinghe S & Mendis KN (1996) Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control. Transactions of the Royal Society of Tropical Medicine and Hygiene 90, 563-567.
5. Hogh B, Gamage-Mendis A, Butcher GA et al. (1998) Differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector. American Journal of Tropical Medicine and Hygiene 58, 176-182.
6. Robert V, Molez JF & Trape JF (1996) Gametocytes, chloroquine pressure, and the relative parasite survival advantage of resistant strains of falciparum malaria in West Africa. American Journal of Tropical Medicine and Hygiene 55, 350-351.
7. Robert V, Awono-Ambene HP, Le Hesran JY & Trape JF (2000) Gametocytaemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine. American Journal of Tropical Medicine and Hygiene 62, 210-216.
8. Salako LA, Ajayi FO, Sowunmi A & Walker O (1990) Malaria in Nigeria: a revisit. Annals of Tropical Medicine and Parasitology 84, 435-445.
9. Sinden RE (1982) Gametocytogenesis of Plasmodium falciparum in vitro: ultrastructural observations on the lethal action of chloroquine. Annals of Tropical Medicine and Parasitology 76, 15-23.
10. Sinden RE (1983) Sexual development of malaria parasites. Advances in Parasitology 22, 153-216.
11. Smalley ME & Sinden RE (1977) Plasmodium falciparum gametocytes: their longevity and infectivity. Parasitology 74, 1-8.
12. Sowunmi A (2002) A randomized comparison of chloroquine, amodiaquine and their combination in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology 96, 227-238.
13. Sowunmi A (2003) A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology 97, 103-117.
14. Sowunmi A & Fateye BA (2002) Studies on Plasmodium falciparum gametocytaemia in children: peripheral immature gametocytaemia as a marker of response to chloroquine treatment in children from an endemic area. American Society of Tropical Medicine and Hygiene Annual Meeting, Denver, Colorado, November 10-14 2002, abstract no. 1461.
15. Sowunmi A & Fateye BA (2003) Asymptomatic recrudescent chloroquine-resistant Plasmodium falciparum infections in Nigerian children: clinical and parasitological characteristics and implications for transmission of drug resistant infections. Annals of Tropical Medicine and Parasitology 97, 469-479.
16. Sowunmi A & Salako LA (1992) Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria. Annals of Tropical Medicine and Parasitology 86, 1-8.
17. Sowunmi A, Oduola AMJ, Ogundahunsi OAT, Falade CO, Gbotosho GO & Salako LA (1997) Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children. Transactions of the Royal Society of Tropical Medicine and Hygiene 91, 63-67.
18. Sowunmi A, Oduola AMJ, Ogundahunsi OAT & Salako LA (1998a) Comparative efficacy of chloroquine plus chlorpheniramine and pyrimethamine/sulphadoxine in acute uncomplicated falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 77-81.
19. Sowunmi A, Fehintola FA, Ogundahunsi OAT & Oduola AMJ (1998b) Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 92, 441-445.
20. Sowunmi A, Oduola AMJ, Ogundahunsi OAT & Salako LA (1998c) Enhancement of the antimalarial effect of chloroquine by chlorpheniramine in vivo. Tropical Medicine and International Health 3, 177-183.
21. SPSS (1999) SPSS for Windows Release 10.0.1 (Standard Version). SPSS Inc, Chicago, IL, USA.
22. Sutherland CJ, Alloueche A, Curtis J et al. (2002) Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum carrying resistance genes. American Journal of Tropical Medicine and Hygiene 67, 578-585.
23. Tjitra E, Suprianto S & Anstey NM (2002) Higher gametocyte prevalence following failure of treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine and the combination of chloroquine plus sulfadoxine-pyrimethamine: implications for progression of anti-folate resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene 96, 434-437.
24. Trape JF, Pison G, Preziosi MP et al. (1998) Impact of chloroquine resistance on malaria mortality. Life Sciences 321, 689-697.
25. Warrell DA, Molyneux ME & Beales PF (1990) Severe and complicated malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 80 (suppl.), 1-50.
26. World Health Organization (1973) Chemotherapy of Malaria and Resistance to Antimalarials. Technical Report Series No. 529. WHO, Geneva.
27. World Health Organization (2000) Severe falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, Suppl. 1.
28. World Health Organization (2001a) The Use of Antimalarial Drugs. Report of a WHO Informal Consultation. Document WHO/CDS/RBM/2001.33. WHO, Geneva.
29. World Health Organization (2001b) Antimalarial Dug Combination Therapy. Report of a WHO Technical Consultation. Document WHO/CDS/RBM/2001.3S. WHO, Geneva.