Src-like adaptor protein regulates B cell development and function

Journal of Immunology

Volumn 176, Issue 1, 2006, Pages 335-345

  Dragone, Leonard L ^a   Myers, Margaret D ^a,b   White, Carmen ^a   Sosinowski, Tomasz ^c   Weiss, Arthur ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANTIGEN; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; SRC LIKE ADAPTOR PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BINDING AFFINITY; CALCIUM TRANSPORT; CELL MATURATION; CONTROLLED STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 29644432913     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.1.335     Document Type: Article

References (48)

1. Goodnow, C. C., R. Glynne, S. Akkaraju, J. Rayner, D. Mack, J. I. Healy, S. Chaudhry, L. Miosge, L. Wilson, P. Papathanasiou, and A. Loy. 2001. Autoimmunity, self-tolerance, and immune homeostasis: from whole-animal phenotypes to molecular pathways. Adv. Exp. Med. Biol. 490: 33-40.
2. Goodnow, C. C. 2001. Pathways for self-tolerance and the treatment of autoimmune diseases. Lancet 357: 2115-2121.
3. Tang, J., S. Sawasdikosol, J. H. Chang, and S. J. Burakoff. 1999. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. Proc. Natl. Acad. Sci. USA 96: 9775-9780.
4. Pandey, A., H. Duan, and V. M. Dixit. 1995. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J. Biol. Chem. 270: 19201-19204.
5. Sosinowski, T., A. Pandey, V. M. Dixit, and A. Weiss. 2000. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J. Exp. Med. 191: 463-474.
6. Roche, S., G. Alonso, A. Kazlauskas, V. M. Dixit, S. A. Courtneidge, and A. Pandey. 1998. Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr. Biol. 8: 975-978.
7. Manes, G., P. Bello, and S. Roche. 2000. Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes. Mol. Cell. Biol. 20: 3396-3406.
8. + thymocytes and regulates positive selection. Immunity 15: 457-466.
9. Feldhahn, N., I. Schwering, S. Lee, M. Wartenberg, F. Klein, H. Wang, G. Zhou, S. M. Wang, J. D. Rowley, J. Hescheler, et al. 2002. Silencing of B cell receptor signals in human naive B cells. J. Exp. Med. 196: 1291-1305.
10. Glynne, R., G. Ghandour, J. Rayner, D. H. Mack, and C. C. Goodnow. 2000. B-lymphocyte quiescence, tolerance, and activation as viewed by global gene expression profiling on microarrays. Immunol. Rev. 176: 216-246.
11. Glynne, R. J., G. Ghandour, and C. C. Goodnow. 2000. Genomic-scale gene expression analysis of lymphocyte growth, tolerance, and malignancy. Curr. Opin. Immunol. 12: 210-214.
12. Cancro, M. P. 2004. Peripheral B cell maturation: the intersection of selection and homeostasis. Immunol. Rev. 197: 89-101.
13. Li, Y. S., K. Hayakawa, and R. R. Hardy. 1993. The regulated expression of B lineage-associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178: 951-960.
14. Su, T. T., B. Guo, B. Wei, J. Braun, and D. J. Rawlings. 2004. Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol. Rev. 197: 161-178.
15. Niiro, H., and E. A. Clark. 2002. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2: 945-956.
16. Goodnow, C. C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. USA 93: 2264-2271.
17. Hartley, S. B., M. P. Cooke, D. A. Fulcher, A. W. Harris, S. Cory, A. Basten, and C. C. Goodnow. 1993. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell 72: 325-335.
18. Hartley, S. B., J. Crosbie, R. Brink, A. B. Kantor, A. Basten, and C. C. Goodnow. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353: 765-769.
19. Goodnow, C. C., R. Brink, and E. Adams. 1991. Breakdown of self-tolerance in anergic B lymphocytes. Nature 352: 532-536.
20. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
21. Su, T. T., and D. J. Rawlings. 2002. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J. Immunol. 168: 2101-2110.
22. Ginzinger, D. G. 2002. Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. Exp. Hematol. 30: 503-512.
23. ΔΔCT method. Methods 25: 402-408.
24. Elson, D. A., G. Thurston, L. E. Huang, D. G. Ginzinger, D. M. McDonald, R. S. Johnson, and J. M. Arbeit. 2001. Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev. 15: 2520-2532.
25. Ostberg, J. R., L. L. Dragone, T. Driskell, J. A. Moynihan, R. Phipps, R. K. Barth, and J. G. Frelinger. 1996. Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency. J. Immunol. 157: 4876-4884.
26. Berg, L. J., and J. Kang. 2001. Molecular determinants of TCR expression and selection. Curr. Opin. Immunol. 13: 232-241.
27. Casola, S., K. L. Otipoby, M. Alimzhanov, S. Humme, N. Uyttersprot, J. L. Kutok, M. C. Carroll, and K. Rajewsky. 2004. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5: 317-327.
28. + thymocytes influenced by CD4. Nature 344: 247-251.
29. Myers, M. D., L. L. Dragone, and A. Weiss. 2005. Src-like adaptor protein downregulates TCR-CD3 expression by targeting TCRz for degradation. J. Cell Biol. 170: 285-294.
30. Cassard, S., J. Salamero, D. Hanau, D. Spehner, J. Davoust, W. H. Fridman, and C. Bonnerot. 1998. A tyrosine-based signal present in Ig-α mediates B cell receptor constitutive internalization. J. Immunol. 160: 1767-1773.
31. Chung, J. B., M. Silverman, and J. G. Monroe. 2003. Transitional B cells: step by step towards immune competence. Trends Immunol. 24: 343-349.
32. Gauld, S. B., J. M. Dal Porto, and J. C. Cambier. 2002. B cell antigen receptor signaling: roles in cell development and disease. Science 296: 1641-1642.
33. Meffre, E., R. Casellas, and M. C. Nussenzweig. 2000. Antibody regulation of B cell development. Nat. Immunol. 1: 379-385.
34. Gu, H., D. Tarlinton, W. Muller, K. Rajewsky, and I. Forster. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173: 1357-1371.
35. Bannish, G., E. M. Fuentes-Panana, J. C. Cambier, W. S. Pear, and J. G. Monroe. 2001. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J. Exp. Med. 194: 1583-1596.
36. Reichlin, A., A. Gazumyan, H. Nagaoka, K. H. Kirsch, M. Kraus, K. Rajewsky, and M. C. Nussenzweig. 2004. A B cell receptor with two Ig-α cytoplasmic domains supports development of mature but anergic B cells. J. Exp. Med. 199: 855-865.
37. Reichlin, A., Y. Hu, E. Meffre, H. Nagaoka, S. Gong, M. Kraus, K. Rajewsky, and M. C. Nussenzweig. 2001. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin-β. J. Exp. Med. 193: 13-23.
38. Cyster, J. G., and C. C. Goodnow. 1995. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 2: 13-24.
39. Cyster, J. G. 1997. Signaling thresholds and interclonal competition in preimmune B-cell selection. Immunol. Rev. 156: 87-101.
40. Naramura, M., H. K. Kole, R. J. Hu, and H. Gu. 1998. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl. Acad. Sci. USA 95: 15547-15552.
41. Murphy, M. A., R. G. Schnall, D. J. Venter, L. Barnett, I. Bertoncello, C. B. Thien, W. Y. Langdon, and D. D. Bowtell. 1998. Tissue hyperplasia and enhanced T-cell signaling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell. Biol. 18: 4872-4882.
42. Langdon, W. Y., C. D. Hyland, R. J. Grumont, and H. C. Morse III. 1989. The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein. J. Virol. 63: 5420-5424.
43. Thien, C. B., and W. Y. Langdon. 2001. Cbl: many adaptations to regulate protein tyrosine kinases. Nat. Rev. Mol. Cell Biol. 2: 294-307.
44. 2-dependent ubiquitin-protein ligase. Science 286: 309-312.
45. de Melker, A. A., G. van der Horst, J. Calafat, H. Jansen, and J. Borst. 2001. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J. Cell Sci. 114: 2167-2178.
46. Donovan, J. A., R. L. Wange, W. Y. Langdon, and L. E. Samelson. 1994. The protein product of the c-cbl proto-oncogene is the 120-kDa tyrosine- phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem. 269: 22921-22924.
47. Rao, N., M. L. Lupher, Jr., S. Ota, K. A. Reedquist, B. J. Druker, and H. Band. 2000. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J. Immunol. 164: 4616-4626.
48. Myers, M. D., T. Sosinowski, L. L. Dragone, C. White, H. Band, and A. Weiss. 2005. Nat. Immunol. In press.