Disregulated Expression of CD43 (Leukosialin, Sialophorin) in the B Cell Lineage Leads to Immunodeficiency

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 4876-4884

  Ostberg, Julie R ^a   Dragone, Leonard L ^a   Driskell, Tina ^a   Moynihan, Jan A ^a   Phipps, Richard ^a   Barth, Richard K ^a   Frelinger, John G ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOCYANIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; KEYHOLE LIMPET HEMOCYANIN; KEYHOLE-LIMPET HEMOCYANIN; LEUKOCYTE ANTIGEN; LEUKOSIALIN; LIPOPOLYSACCHARIDE; OVALBUMIN; SIALOGLYCOPROTEIN; SPN PROTEIN, MOUSE;

ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BIOLOGICAL MODEL; BIOSYNTHESIS; C57BL MOUSE; CELL ADHESION; CELL DIFFERENTIATION; DBA MOUSE; GENE EXPRESSION; GENETICS; IMMUNE DEFICIENCY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; METABOLISM; MOUSE; PATHOLOGY; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD43; B-LYMPHOCYTES; CELL ADHESION; CELL DIFFERENTIATION; GENE EXPRESSION; HEMOCYANIN; IMMUNOGLOBULIN M; IMMUNOGLOBULINS; IMMUNOLOGIC DEFICIENCY SYNDROMES; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MODELS, BIOLOGICAL; OVALBUMIN; SIALOGLYCOPROTEINS; SPLEEN;

EID: 0030459357     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (78)

1. Fukuda, M. 1991. Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy. Glycobiol. 1:347.
2. Pallant, A., A. Eskenazi, M. G. Mattei, R. E. Fournier, S. R. Carlsson, M. Fukuda, and J. G. Frelinger. 1989. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc. Natl. Acad. Sci. USA 86:1328.
3. Shelley, C. S., E. Remold-O'Donnell, F. S. Rosen, and A. S. Whitehead. 1990. Structure of the human sialophorin (CD43) gene: identification of features atypical of genes encoding integral membrane proteins. Biochem. J. 270:569.
4. Cyster, J., C. Somoza, N. Killeen, and A. F. Williams. 1990. Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. Eur. J. Immunol. 20:875.
5. Dorfman, K. S., W. Litaker, C. M. Baecher, and J. G. Frelinger. 1990. The nucleotide sequence of Ly 48 (mouse leukosialin, sialophorin): the mouse homolog of CD43. Nucleic Acids Res. 18:4932.
6. Cyster, J. G., D. M. Shotton, and A. F. Williams. 1991. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 10:893.
7. Shimizu, Y., and S. Shaw. 1993. Cell adhesion: mucins in the mainstream. Nature 366:630.
8. Williams, A. F. 1991. Cellular interactions: out of equilibrium. Nature 352:473.
9. Parkman, R., E. Remold-O'Donnell, D. M. Kenney, S. Perrine, and F. S. Rosen. 1981. Surface protein abnormalities in lymphocytes and platelets from patients with Wiskott-Aldrich syndrome. Lancet 2:1387.
10. Remold-O'Donnell, E., D. M. Kenney, R. Parkman, L. Cairns, B. Savage, and F. S. Rosen. 1984. Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome. J. Exp. Med. 159:1705.
11. Mentzer, S. J., E. Remold-O'Donnell, M. A. Crimmins, B. E. Bierer, F. S. Rosen, and S. J. Burakoff. 1987. Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation. J. Exp. Med. 165:1333.
12. Ardman, B., M. A. Sikorski, M. Settles, and D. E. Staunton. 1990. Human immunodeficiency virus type 1-infected individuals make autoantibodies that bind to CD43 on normal thymic lymphocytes. J. Exp. Med. 172:1151.
13. Abramson, J. S., and H. R. Hudnor. 1995. Role of the sialophorin (CD43) receptor in mediating influenza A virus-induced polymorphonuclear leukocyte dysfunction. Blood 85:1615.
14. Hartshorn, K. L., L. S. Liou, M. R. White, M. M. Kazhdan, J. L. Tauber, and A. I. Tauber. 1995. Neutrophil deactivation by influenza A virus: role of hemagglutinin binding to specific sialic acid-bearing cellular proteins. J. Immunol. 154:3952.
15. Rothwell, S. W., and D. G. Wright. 1994. Characterization of influenza A virus binding sites on human neutrophils. J. Immunol. 152:2358.
16. Ostberg, J. R., L. L. Dragone, R. Waugh, D. Ryan, J. G Frelinger, and R. K. Barth. 1996. Disregulated expression of leukosialin (CD43) in the erythroid lineage of transgenic mice results in microcytosis. Transgenics 2:41.
17. Misawa, Y., and M. Shibuya. 1992. Amplification and rearrangement of melF/mouse CD43 (leukosialin) gene encoding a highly glycosylated membrane protein gp120 in Friend erythroleukemia cells. Oncogene 7:919.
18. Baeckstrom, D., K. Zhang, N. Asker, U. Ruetschi, M. Ek, and G. C. Hansson. 1995. Expression of the leukocyte-associated sialoglycoprotein CD43 by a colon carcinoma cell line. J. Biol. Chem. 270:13688.
19. Nong, Y. H., E. Remold-O'Donnell, T. W. LeBien, and H. G. Remold. 1989. A monoclonal antibody to sialophorin (CD43) induces homotypic adhesion and activation of human monocytes. J. Exp. Med. 170:259.
20. Silverman, L. B., R. C. Wong, E. Remold-O'Donnell, D. Vercelli, J. Sancho, C. Terhorst, F. Rosen, R. Geha, and T. Chatila. 1989. Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. J. Immunol. 142:4194.
21. Vargas-Cortes, M., B. Axelsson, A. Larsson, T. Berzins, and P. Perlmann. 1988. Enhancement of human spontaneous cell-mediated cytotoxicity by a monoclonal antibody against the large sialoglycoprotein (CD 43) on peripheral blood lymphocytes. Scand. J. Immunol. 27:661.
22. Bazil, V., J. Brandt, A. Tsukamoto, and R. Hoffman. 1995. Apoptosis of human hematopoietic progenitor cells induced by crosslinking of surface CD43, the major sialoglycoprotein of leukocytes. Blood 86:502.
23. Axelsson, B., R. Youseffi-Etemad, S. Hammarstrom, and P. Perlmann. 1988. Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43. J. Immunol. 141:2912.
24. Park, J. K., Y. J. Rosenstein, E. Remold-O'Donnell, B. E. Bierer, F. S. Rosen, and S. J. Burakoff. 1991. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature 350:706.
25. Sperling, A. I., J. M. Green, R. L. Mosley, P. L. Smith, R. J. DiPaolo, J. R. Klein, J. A. Bluestone, and C. B. Thompson. 1995, CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J. Exp. Med. 182:139.
26. Rosenstein, Y., J. K. Park, W. C. Hahn, F. S. Rosen, B. E. Bierer, and S. J. Burakoff. 1991. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 354:233.
27. Nathan, C., Q. W. Xie, L. Halbwachs-Mecarelli, and W. W. Jin. 1993. Albumin inhibits neutrophil spreading and hydrogen peroxide release by blocking the shedding of CD43 (sialophorin, leukosialin). J. Cell Biol. 122:243.
28. Sawada, R., S. Tsuboi, and M. Fukuda. 1994. Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials. J Biol. Chem. 269:1425.
29. Baum, L. G., M. Pang, N. L. Perillo, T. Wu, A. Delegeane, C. H. Uittenbogaart, M. Fukuda, and J. J. Seilhamer. 1995. Human thymic epithelial cells express an endogenous lectin, galectin-1. which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med. 181:877.
30. Ardman, B., M. A. Sikorski, and D. E. Staunton. 1992. CD43 interferes with T-lymphocyte adhesion. Proc. Natl. Acad. Sci. USA 89:5001.
31. Manjunath, N., R. S. Johnson, D. E. Staunton, R. Pasqualini, and B. Ardman. 1993. Targeted disruption of CD43 gene enhances T lymphocyte adhesion. J. Immunol. 151:1528.
32. Wiken, M., E. S. Rubertsson, B. Axelsson, and P. Perlmann. 1987. Functional characterization of human B cells carrying the lymphocyte large sialoglycoprotein gp150. Scand. J. Immunol. 26:477.
33. Roxburgh, A. E., and I. A. Cooper. 1987. Expression of leucocyte-common antigen and large sialoglycoprotein on leukemic cells in B-cell chronic lymphocytic leukemia and non-Hodgkin's lymphoma. Leukemia Res. 11:891.
34. Wiken, M., P. Bjorck, B. Axelsson, and P. Perlmann. 1988. Induction of CD43 expression during activation and terminal differentiation of human B cells. Scand. J. Immunol. 28:457.
35. Gulley, M. L., L. C. Ogata, J. A. Thorson, M. O. Dailey, and J. D. Kemp. 1988. Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation. J. Immunol. 140:3751.
36. Hardy, R. R., J. D. Kemp, and K. Hayakawa. 1989. Analysis of lymphoid population in scid mice: detection of a potential B lymphocyte progenitor population present at normal levels in scid mice by three-color flow cytometry with B220 and S7. Curr. Top. Microbiol. Immunol. 152:19.
37. Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
38. Bjorck, P., B. Axelsson, and S. Paulie. 1991. Expression of CD40 and CD43 during activation of human B lymphocytes. Scand. J. Immunol. 33:211.
39. Dragone, L. L., R. K. Barth, K. L. Sitar, G. L. Disbrow, and J. G. Frelinger. 1995. Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival. Proc. Natl. Acad. Sci. USA 92:626.
40. McDonnell, T. J., N. Deane, F. M. Platt, G. Nunez, U. Jaeger, J. P. McKeam, and S. J. Korsmeyer. 1989. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79.
41. McDonnell, T. J., G. Nunez, F. M. Platt, D. Hockenberry, L. London, J. P. McKearn, and S. J. Korsmeyer. 1990. Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M- and D-expressing B-cell population. Mol. Cell. Biol. 10:1901.
42. Strasser, A., S. Whittingham, D. L. Vaux, M. L. Bath, J. M. Adams, S. Cory, and A. W. Harris. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA 88.-8661.
43. Mathis, D. J., C. Benoist, V. E. d. Williams, M. Kanter, and H. O. McDevitt. 1983. Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc. Natl. Acad. Sci. USA 80:273.
44. McNicholas, J., M. Steinmetz, T. Hunkapiller, P. Jones, and L. Hood. 1982. DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse. Science 218:1229.
45. Baecher, C. M., A. J. Infante, K. L. Semcheski, and J. G. Frelinger. 1988. Identification and characterization of a mouse cell surface antigen with alternative molecular forms. Immunogenetics 28:295.
46. Baecher-Allan, C. M., J. D. Kemp, K. S. Dorfman, R. K. Barth, and J. G. Frelinger. 1993. Differential epitope expression of Ly-48 (mouse leukosialin). Immunogenetics 37:183.
47. Kung, J. T., S. O. Sharrow, D. G. Sieckmann, R. Lieberman, and W. E. Paul. 1981. A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. J. Immunol. 127:873.
48. Bhattacharya, A., M. E. Dorf, and T. A. Springer. 1981. A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127:2488.
49. Kincade, P. W., G. Lee, T. Watanabe, L. Sun, and M. P. Scheid. 1981. Antigens displayed on murine B lymphocyte precursors. J. Immunol. 127:2262.
50. Dialynas, D. P., Z. S. Quan, K. A. Wall, A. Pierres, J. Quintans, M. R. Loken, M. Pierres, and F. W. Fitch. 1983. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131:2445.
51. Ledbetter, J. A., and L. A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63.
52. Bahler, D. W., K. M. Cerosaletti, E. M. Lord, and J. G. Frelinger. 1988. Molecular analysis of deficient class I H-2 antigen expression by mouse lung carcinoma cells. J. Immunol. 140:4003.
53. Baecher-Allan, C. M., and R. K. Barth. 1993. PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis. Reg. Immunol. 5:207.
54. Scott, D. W. 1976. Antifluorescein affinity columns: isolation and immunocompetence of lymphocytes that bind fluoresceinated antigens in vivo or in vitro. J. Exp. Med 144:69.
55. Snapper, C. M., F. D. Finkelman, and W. E. Paul. 1988. Regulation of IgG1 and IgE production by interleukin 4. Immunol. Rev. 102:51.
56. Phipps, R. P., M. Spaulding, and J. Szakos. 1988. DNA is a potent immunogen for spleen cells and for guanosine-binding B lymphocytes. Cell. Immunol. 113: 202.
57. Shastri, N., and F. Gonzalez. 1993. Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells. J. Immunol. 150:2724.
58. Cyster, J. G., and A. F. Williams. 1992. The importance of cross-linking in the homotypic aggregation of lymphocytes induced by anti-leukosialin (CD43) antibodies. Eur. J. Immunol. 22:2565.
59. Kuijpers, T. W., M. Hoogerwerf, K. C. Kuijpers, B. R. Schwartz, and J. M. Harlan. 1992. Cross-linking of sialophorin (CD43) induces neutrophil aggregation in a CD18-dependent and a CD18-independent way. J. Immunol. 149:998.
60. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
61. Logtenberg, T., M. Jonker, A. Kroon, F. H. Gmelig-Meyling, and R. E. Ballieux. 1985. Enumeration of (auto)antibody producing cells in human using the "spot-ELISA." Immunol. Lett. 9:343.
62. Wismans, P. J., J. van Hattum, G. C. De Gast, H. J. Endeman, J. Poel, B. Stolk, T. Maikoe, and G. C. Mudde. 1989. The spot-ELISA: a sensitive in vitro method to study the immune response to hepatitis B surface antigen. Clin. Exp. Immunol. 78:75.
63. Mazer, B. D., H. Renz, and E. W. Gelfand. 1991. An ELISA spot assay for quantitation of human immunoglobulin-secreting cells. J. Allergy Clin. Immunol. 88:235.
64. Bednarczyk, J. L., and B. W. McIntyre. 1990. A monoclonal antibody to VLA-4 α-chain (CDw49d) induces homotypic lymphocyte aggregation. J. Immunol. 144: 777.
65. Wagner, N., P. Engel, M. Vega, and T. F. Tedder. 1994. Ligation of MHC class I and class II molecules can lead to heterologous desensitization of signal transduction pathways that regulate homotypic adhesion in human lymphocytes. J. Immunol. 152:5275.
66. Markowitz, J. S., P. R. Rogers, M. J. Grusby, D. C. Parker, and L. H. Glimcher. 1993. B lymphocyte development and activation independent of MHC class II expression. J. Immunol. 150:1223.
67. Hilkens, J., M. J. Ligtenberg, H. L. Vos, and S. V. Litvinov. 1992. Cell membrane-associated mucins and their adhesion-modulating property. Trends Biochem. Sci. 17:359.
68. Brown, W. R., A. N. Barclay, C. A. Sunderland, and A. F. Williams. 1981. Identification of a glycophorin-like molecule at the cell surface of rat thymocytes. Nature 289:456.
69. Clark, E. A., and J. A. Ledbetter. 1994. How B and T cells talk to each other. Nature 367:425.
70. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multislep paradigm. Cell 76:301.
71. Fukuda, M., and S. R. Carlsson. 1986. Leukosialin, a major sialoglycoprotein on human leukocytes as differentiation antigens. Med. Biol. 64:335.
72. Manjunath, N., M. Correa, M. Ardman, and B. Ardman. 1995. Negative regulation of T-cell adhesion and activation by CD43. Nature 377:535.
73. Campanero, M. R., R. Pulido, J. L. Alonso, J. P. Pivel, F. X. Pimentel-Muinos, M. Fresno, and F. Sanchez-Madrid. 1991. Down-regulation by tumor necrosis factor-alpha of neutrophil cell surface expression of the sialophorin CD43 and the hyaluronate receptor CD44 through a proteolytic mechanism. Eur. J. Immunol. 21:3045.
74. Bazil, V., and J. L. Strominger. 1993. CD43, the major sialoglycoprotein of human leukocytes, is proteolytically cleaved from the surface of stimulated lymphocytes and granulocytes. Proc. Natl Acad. Sci. USA 90:3792.
75. Carson, D. D., L. H. Rohde, and G. Surveyor. 1994. Cell surface glycoconjugates as modulators of embryo attachment to uterine epithelial cells: review. Int. J. Biochem. 26:1269.
76. Schauer, R. 1982. Chemistry, metabolism, and biological functions of sialic acids. Adv. Carbohydr. Chem. Biochem. 40:131.
77. Niv, Y. 1994. Mucin and colorectal cancer metastasis. Am. J. Gastroenterol. 89:665.
78. Lasky, L. A. 1995. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu. Rev. Biochem. 64:113.