Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland

Toxicological Sciences

Volumn 89, Issue 1, 2006, Pages 83-92

  Randi, Andrea S ^a   Cocca, Claudia ^a   Carbone, Verónica ^a   Nuñez, Mariel ^a   Croci, Máximo ^b   Gutiérrez, Alicia ^a   Bergoc, Rosa ^a   Kleiman de Pisarev, Diana L ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Instituto de Inmunooncología Ernesto J V Crescenti   (Argentina)

Author keywords

Hexachlorobenzene; Insulin receptor; Insulin receptor substrate 1; Insulin like growth factor I receptor; Mammary tumors; N nitroso N methylurea

Indexed keywords

CARCINOGEN; HEXACHLOROBENZENE; INSULIN RECEPTOR; METHYLNITROSOUREA; PROTEIN TYROSINE KINASE; SOMATOMEDIN; SOMATOMEDIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; MAMMARY GLAND; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; COCARCINOGENESIS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FEMALE; HEXACHLOROBENZENE; INSULIN-LIKE GROWTH FACTOR I; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; METHYLNITROSOUREA; PHOSPHOPROTEINS; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 29544452757     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj023     Document Type: Article

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