New drugs in the treatment of epilepsy in children

Current Problems in Pediatric and Adolescent Health Care

Volumn 35, Issue 10, 2005, Pages 398-419

  Donner, Elizabeth J ^a   Snead III, O Carter ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; CALCIUM ION; CARBAMAZEPINE; CLONAZEPAM; CONTRACEPTIVE AGENT; CYTOCHROME P450; CYTOCHROME P450 3A; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; FOSPHENYTOIN SODIUM; GABAPENTIN; GLUTAMATE DECARBOXYLASE; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID; NITRAZEPAM; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

AGITATION; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ANXIETY; APLASTIC ANEMIA; ASTHENIA; ATAXIA; BEHAVIOR DISORDER; BODY WEIGHT DISORDER; CARDIOVASCULAR DISEASE; CAREGIVER; CHILDHOOD DISEASE; CHRONIC DISEASE; CLINICAL FEATURE; CLINICAL TRIAL; CLOSED ANGLE GLAUCOMA; COGNITION; DIFFERENTIAL DIAGNOSIS; DIPLOPIA; DISEASE CLASSIFICATION; DISEASE CONTROL; DIZZINESS; DRUG COST; DRUG EFFICACY; DRUG MECHANISM; ELECTROENCEPHALOGRAPHY; EMPLOYMENT; EPIDERMOLYSIS; EPILEPSY; FOCAL EPILEPSY; GRAND MAL SEIZURE; HEALTH CARE ACCESS; HEALTH CARE COST; HEALTH CARE NEED; HUMAN; HYPERCHLOREMIA; HYPERTHERMIA; INFECTION; INJECTION PAIN; KIDNEY DYSFUNCTION; LABORATORY TEST; LEARNING; LIVER DYSFUNCTION; LIVER FAILURE; METABOLIC ACIDOSIS; MORBIDITY; MORTALITY; MYOPIA; NAUSEA; NEPHROLITHIASIS; NEUROTRANSMISSION; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; QUALITY OF LIFE; RASH; RETINA DISEASE; REVIEW; SEDATION; SOMNOLENCE; STEVENS JOHNSON SYNDROME;

EID: 29444454133     PISSN: 15385442     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cppeds.2005.09.004     Document Type: Article

References (109)

1. B.S. Chang D.H. Lowenstein Epilepsy N Engl J Med 349 2003 1257-1266
2. P. Kwan M.J. Brodie Early identification of refractory epilepsy N Engl J Med 342 2000 314-319
3. E. Beghi B. Frigeni M. Beghi et al. A review of the costs of managing childhood epilepsy Pharmacoeconomics 23 2005 27-45
4. Canadian Clobazam Cooperative Group Clobazam in treatment of refractory epilepsy: The Canadian experience. A retrospective study Epilepsia 32 1991 407-416
5. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised clinical and electroencephalographic classification of epileptic seizures Epilepsia 22 1981 489-501
6. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised classification of epilepsies and epileptic syndromes Epilepsia 30 1989 389-399
7. J. Engel A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: Report of the ILAE task force on classification and terminology Epilepsia 42 6 2001 796-803
8. W.B. Jennett Early traumatic epilepsy: Definition and identity Lancet 1 1969 1023-1025
9. F.E. Jensen C.D. Applegate D. Holtzman et al. Epileptogenic effect of hypoxia in the immature rodent brain Ann Neurol 29 1991 629-637
10. W.A. Hauser D.C. Hesdorffer editors Epilepsy Frequency, Causes and Consequences 1990 Demos Publications New York, NY
11. Y. Huang J.J. Doherty R. Dingledine Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus J Neurosci 22 2002 8422-8428
12. M.A. Cortez J.-L. Perez-Velazquez O.C. Snead Animal models of epilepsy and progressive effects of seizures In: W. Blume editor Intractable Epilepsy 2005 Lippincott, Williams, and Wilkins Philadelphia, PA (in press).
13. I. Serbanescu M.A. Cortez C. Mckerlie et al. Refractory atypical absence seizures in rat: A two hit model Epilepsy Res 62 2004 53-63
14. O.C. Snead A. Depaulis M. Vergnes et al. Absence epilepsy: Advances in experimental animal models Adv Neurol 79 1999 253-278
15. H.S. White Animal models of epileptogenesis Neurology 12 suppl 5 2002 S7-S14
16. S. Shinnar A.T. Berg Does antiepileptic drug therapy prevent the development of "chronic epilepsy"? Epilepsia 37 1996 701-708
17. G.L. Holmes Y. Ben-Ari The neurobiology and consequences of epilepsy in the developing brain Pediatr Res 49 2001 320-325
18. D.A. McCormick D. Contreras On the cellular and network bases of epileptic seizures Ann Rev Physiol 63 2001 815-846
19. O.C. Snead Basic mechanisms of generalized absence seizures Ann Neurol 37 1995 146-157
20. V. Crunelli N. Leresche Childhood absence epilepsy genes, channels, neurons, and networks Nature Rev Neurosci 3 2002 371-382
21. S.L. Moshe B.J. Albala R.F. Ackermann et al. Increased seizure susceptibility of the immature brain Dev Brain Res 7 1983 81-85
22. H.B. Michelson E.W. Lothman An in vivo electrophysiological study of the ontogeny of excitatory and inhibitory processes in the rat hippocampus Dev Brain Res 47 1989 113-122
23. W.E. Dodson Pharmacokinetic principles of antiepileptic therapy in children In: J.M. Pellock W.E. Dodson B.F.D. Bourgeois editors 2nd ed. Pediatric Epilepsy Diagnosis and Therapy Vol. 23 2001 Demos Medical Publishing, Inc New York, NY 317-327
24. D.W. Dunn Neuropsychiatric aspects of epilepsy in children Epilepsy Behav 4 2 2003 101-106
25. S. Shinnar J.M. Pellock Update on the epidemiology and prognosis of pediatric epilepsy J Child Neurol 17 suppl 1 2002 S4-S17
26. D. Hirtz S. Ashwal A. Berg et al. Practice parameter evaluating a first nonfebrile seizure in children Neurology 55 2000 616-623
27. D.L. Gilbert R.C. Buncher An EEG should not be obtained routinely after first unprovoked seizure in childhood Neurology 54 2000 635-641
28. M. Musicco E. Beghi A. Solari First Seizure Trial Group Effect of antiepileptic treatment initiated after the first unprovoked seizure on the long-term prognosis of epilepsy Neurology 44 suppl 2 1994 A337-A338
29. M. Sahin C.C. Menache G.L. Holmes et al. Prolonged treatment for acute symptomatic refractory status epilepticus: Outcome in children Neurology 61 2003 398-401
30. D.A. Coulter D.C. McIntyre W. Loscher Animal models of limbic epilepsies what can they tell us? Brain Pathol 12 2002 240-256
31. A.D. Saint-Martin C. Seegmuller R. Carcangiu et al. Cognitive consequences of Rolandic epilepsy Epileptic Dis No. 2 2001 S159-S165
32. P. Camfield C. Camfield Epileptic syndromes in childhood clinical features, outcomes, and treatment Epilepsia 43 suppl 3 2002 27-32
33. A.W. Yung Y.D. Park M.J. Cohen et al. Cognitive and behavioral problems in children with centrotemporal spikes Pediatr Neurol 23 5 2000 391-395
34. C. Helmstaedter M. Kurthen S. Lux et al. Chronic epilepsy and cognition a longitudinal study in temporal lobe epilepsy Ann Neurol 54 4 2003 425-432
35. M. Sillanpaa M. Jalava O. Kaleva et al. Long-term prognosis of seizures with onset in childhood N England J Med 338 1998 1715-1722
36. V. Miller T.M. Palermo S.C. Grewe Quality of life in pediatric epilepsy demographic and disease-related predictors and comparison with healthy controls Epilepsy Behav 4 2003 36-42
37. J.K. Austin G.A. Huster D. Dunn et al. Adolescents with active or inactive epilepsy or asthma a comparison of quality of life Epilepsia 37 1996 1228-1238
38. D. Russell-Jones S.D. Shorvon The frequency and sequelae of head injury in epilepsy J Neurol Neurosurg Psychiat 52 1989 659-662
39. W.A. Hauser J.F. Annegers L.R. Elveback Mortality in patients with epilepsy Epilepsia 21 1980 339-412
40. A.S. Harvey T. Nolan J.B. Carlin "Community based study of mortality in children with epilepsy." Epilepsia 34 4 1993 597-603
41. E.J. Donner C.R. Smith O.C. Snead Sudden unexplained death in children with epilepsy Neurology 57 2001 430-434
42. P.R. Camfield C.S. Camfield J.M. Dooley et al. Epilepsy after a first unprovoked seizure in childhood Neurology (Cleve) 35 1984 1657-1660
43. W.A. Hauser V.E. Anderson R.B. Lowenson et al. Seizure recurrence after a first unprovoked seizure N Engl J Med 307 1982 522-528
44. D.G. Hirtz J.H. Ellenberg K.B. Nelson The risk of recurrence of nonfebrile seizures in children Neurology 34 1984 637-641
45. S. Shinnar A.T. Berg S.L. Moshe et al. Risk of seizure recurrence following a first unprovoked seizure in childhood. A prospective study Pediatrics 85 1990 1076-1085
46. D. Hirtz A. Berg D. Bettis et al. Practice parameter: Treatment of the child with a first unprovoked seizure: Report of the quality standards subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society Neurology 60 2 2003 166-175
47. M.A. Rogawski W. Loscher The neurobiology of antiepileptic drugs Nat Rev Neurosci 5 2004 553-564
48. J.M. Pellock Felbamate Epilepsia 40 suppl 5 1999 S57-S62
49. S.M. LaRoche S.L. Helmers The new antiepileptic drugs. Scientific review J Am Med Assoc 291 2004 605-614
50. M. Bialer S.I. Johannessen H.J. Kupferberg et al. Progress report on new antiepileptic drugs a summary of the Seventh Eilat Conference (EILAT VII) Epilepsy Res 61 2004 1-48
51. The Felbamate Study Group in Lennox-Gastaut Syndrome Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome) N Engl J Med 328 1993 29-33
52. L. Carmant G.L. Holmes S. Sawyer et al. Efficacy of felbamate in therapy for partial epilepsy in children J Pediatr 125 1994 481-486
53. I.E. Leppik Felbamate Epilepsia 36 suppl 2 1995 S66-S72
54. T.A. Glauser N.M. Graves Phenytoin and fosphenytoin In: E. Wyllie editor. 3rd edition. The Treatment of Epilepsy, Principles and Practice Vol. 58 2001 Lippincott Williams & Wilkins Philadelphia, PA 853-868
55. M.J. McLean Gabapentin In: E. Wyllie editor 3rd ed. The Treatment of Epilepsy, Principles and Practice Vol. 62 2001 Lippincott Williams & Wilkins Philadelphia, PA 915-932
56. R. Appleton K. Fichtner L. LaMoreaux et al. Gabapentin as add-on therapy in children with refractory partial seizures a 12-week, multicenter, double-blind, placebo controlled study Epilepsia 40 8 1999 1147-1154
57. D.Y. Shapiro D. Nordli T.A. Glauser et al. Gabapentin as add-on therapy for refractory partial seizures in children 1-36 months of age a novel short-term, placebo-controlled trial Epilepsia 41 suppl 7 2000 106
58. M. Bialer S.I. Johannessen H.J. Kupferberg et al. Progess report on new antiepileptic drugs a summary of the Sixth Eilat Conference (EILAT VI) Epilepsy Res 51 1-2 2002 31-71
59. A.M. Bergin M. Connolly New antiepileptic drug therapies Neurologic Clin North Am 20 2002 1163-1182
60. F.G. Gilliam B.E. Gidal Lamotrigine In: E. Wyllie editor 3rd ed. The Treatment of Epilepsy, Principles and Practice Vol. 63 2001 Lippincott Williams & Wilkins Philadelphia, PA 933-938
61. M. Duchowny J.M. Pellock W.D. Graf et al. A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children Neurology 53 1999 1724-1731
62. A.-S. Eriksson A. Nergardh K. Hoppu The efficacy of lamotrigine in children and adolescents with refractory generalized epilepsy; a randomized, double-blind, crossover study Epilepsia 39 1998 495-501
63. J. Motte E. Trevathan J.F.V. Arvidsson et al. The Lamictal Lennox-Gastaut Study Group Lamotrigine for generalized seizures associated with the Lennox-Gastaut syndrome N Engl J Med 337 1997 1807-1812
64. A.H. Guberman F.M. Besag M.J. Brodie et al. Lamotrigine-associated rash risk/benefit considerations in adults and children Epilepsia 40 1999 985-991
65. A.W.C. Yuen G. Land B.C. Weatherley et al. Sodium valproate acutely inhibits lamotrigine metabolism Br J Clin Pharmacol 33 1992 511-513
66. I.C. Wong S.D. Lahtoo Adverse reactions to new anticonvulsant drugs Drug Saf 23 2000 35-36
67. A. Beydoun R.C. Sachdeo E. Kutluay et al. Sustained efficacy and long term safety of oxcarbazepine one-year open-label extension of a study in refractory partial seizures Epilepsia 44 2003 1160-1165
68. M.M. Guerreiro U. Vigonius H. Pohlmann et al. A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy Epilepsy Res 27 1997 205-213
69. M.L. Sillanpaa In: E. Wyllie editor 3rd ed. The Treatment of Epilepsy, Principles and Practice Vol. 56 2001 Lippincott Williams & Wilkins Philadelphia, PA 821-423
70. T. Van Amelsvoort R. Bakshi C.B. et al. Devaux Hyponatremia associated with carbamazepine and oxcarbazepine therapy a review Epilepsia 35 1994 181-188
71. P.E.M. Smith Clinical recommendations for oxcarbazepine Seizure 10 2001 87-91
72. E. Ben-Menachem Pregabalin pharmacology and its relevance to clinical practice Epilepsia 45 suppl 6 2004 13-18
73. M.J. Brodie Pregabalin as adjunctive therapy for partial seizures Epilepsia 45 suppl 6 2004 19-27
74. S.C. Stratton C.H. Large B. Cox et al. Effects of lamotrigine and levetiracetam on seizure-development in a rat amygdala kindling model Epilepsy Res 53 2003 95-106
75. B. Lynch N. Lambeng K. Nocka et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam Proc Natl Acad Sci USA 010 2004 9861-9866
76. B.F.D. Bourgeois D.L. Holder I. Valencia et al. Open label assessment of levetiracetam efficacy and adverse effects in a pediatric population Epilepsia 42 suppl 7 2001 253-254
77. T. Glauser M. Bebin F. Ritter et al. Open-label efficacy and safety of levetiracetam in pediatric patients with partial onset seizures (abstract) Epilepsia 40 1999 161
78. L. Lagae G. Buyse A. Deconinck et al. Effect of levetiracetam in refractory childhood epilepsy syndromes Eur J Pediatr Neurol 7 2003 123-128
79. E.H. Kossoff G.K. Bergey J.M. Freeman et al. Levetiracetam psychosis in children with epilepsy Epilepsia 42 2001 1161-1163
80. S. Shinnar K.W. Sommerville Tiagabine In: J.M. Pellock W.E. Dodson B.F.D. Bourgeois editors 2nd ed. Pediatric Epilepsy Diagnosis and Therapy Vol. 37 2001 Demos Medical Publishing, Inc New York, NY 489-498
81. K.M. Eckardt B.J. Steinhoff Nonconvulsive status epilepticus in two patients receiving tiagabine treatment Epilepsia 39 1998 671-674
82. A.B. Ettinger O.G. Bernal M.R. Andriola et al. Two cases of nonconvulsive status epilepticus in association with tiagabine therapy Epilepsia 40 1999 1159-1162
83. S. Shinnar A.T. Berg D.M. et al. Treiman Status epilepticus and tiagabine therapy review of safety data and epidemiologic comparisons Epilepsia 42 2001 372-379
84. G.L. Krauss M.A. Johnson S. Sheth et al. A controlled study comparing visual function in patients treated with vigabatrin and tiagabine J Neurol Neurosurg Psychiatry 74 2003 339-343
85. R. Kalviainen J.C. Hache J.A. Renault-Dijouadi A study of visual fields in patients receiving tiagabine as monotherapy versus carbamazepine or lamotrigine monotherapy Epilepsia 42 suppl 7 2001 256
86. S.C. Schachter Tiagabine In: E. Wyllie editor 3rd ed. The Treatment of Epilepsy, Principles and Practice Vol. 65 2001 Lippincott Williams & Wilkins Philadelphia, PA 947-952
87. R.J. DeLorenzo S. Sombati D.A. Coulter et al. Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons Epilepsia 41 suppl 1 2000 S40-S44
88. J.W. Gibbs 3rd S. Sombati R.J. Delorenzo et al. Cellular actions of topiramate blockade of kainite-evoked inward currents in cultured hippocampal neurons Epilepsia 41 suppl 2000 510-516
89. H.S. White S.D. Brown J.H. Woodhead et al. Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold Epilepsy Res 28 1997 167-179
90. J. Qian J.L. Noebels Topiramate alters excitatory synaptic transmission in mouse hippocampus Epilepsy Res 55 2003 225-233
91. E. Russo A. Constanti Topiramate hyperpolarizes and modulates the slow poststimulus AAHP of rat olfactory cortical neurons in vitro Br J Pharmacol 1441 2004 285-301
92. D.S. Gryder M.A. Rogawski Selective antagonism of gluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons J Neurosci 23 2003 7069-7074
93. M. Angehagen E. Ben-Menachem R. Shank et al. Topiramate modulation of kainite-induced calcium currents is inversely related to channel phosphorylation level J Neurochem 88 2004 320-356
94. R.D. Elterman T.A. Glauser E. Wyllie et al. A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children Neurology 52 1999 1338-1344
95. T.A. Glauser P.O. Clark R. Strawsburg A pilot study of topiramate in the treatment of infantile spasms Epilepsia 39 12 1998 1324-1328
96. T.A. Glauser Topiramate in the catastrophic epilepsies of childhood J Child Neurol 15 suppl 1 2000 S14-S21
97. R.C. Sachdeo T.A. Glauser F. Ritter et al. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome Neurology 52 1999 1882-1887
98. S. Grosso D. Galimberti M.A. Farnetani et al. Efficacy and safety of topiramate in infants according to epilepsy syndromes Seizure 14 3 2005 183-189
99. D. Battino D. Croci A. Rossini et al. Topiramate pharmacokinetics in children and adults with epilepsy: A case-matched comparison based on therapeutic drug monitoring data Clin Pharmacokinet 44 2005 407-416
100. D.S. Hammoudi S.S.F. Lee A. Madison et al. Reduced visual function associated with infantile spasms in children on vigabatrin therapy Invest Ophthal Vis Sci 46 2005 514-520
101. M.T. Mackay S.K. Weiss T. Adams-Webber et al. Practice parameter medical treatment of infantile spasms Neurology 62 2004 1668-1681
102. P. Curatolo M. Verdecchia R. Bombardieri Vigabatrin for tuberous sclerosis complex Brain Dev 23 7 2001 649-653
103. C.A. Westall W.J. Logan K. Smith et al. The Hospital for Sick Children, Toronto, Longitudinal ERG study of children on vigabatrin Doc Ophthal 104 2 2002 133-149
104. Macdonald R.L, Duche B. et al. Zonisamide - Mechanisms of action In: R.H. Levy R.H. Mattson B.S. Meldrum et al. Antiepileptic Drugs 5th ed. Lippincott, Williams & Wilkins Philadelphia, PA 2002. p.867-72
105. M.J. Brodie R. Duncan H. Vespignani et al. Dose-dependent safety and efficacy of zonisamide a randomized, double-blind, placebo-controlled study in patients with refractory partial seizures Epilepsia 46 2005 31-41
106. R.S. Fisher J.F. Kerrigan III J.M. Pellock Zonisamide In: J.M. Pellock W.E. Dodson B.F.D. Bourgeois editors Pediatric Epilepsy Diagnosis and Therapy 2nd ed. 2001 Demos Medical Publishing, Inc New York, NY p. 39:509-12
107. E. Beghi Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines Lancet Neurol 3 2004 618-621
108. S. Beyenburg J. Bauer M. Reuber New drugs for treatment of epilepsy a practical approach Postgrad Med J 80 2004 581-587
109. R. Sankar G.L. Holmes Mechanism of action for the commonly used antiepileptic drugs relevance to antiepileptic drug-associated neurobehavioral adverse effects J Child Neurol 19 suppl 1 2004 S6-S14