Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis

Neuropharmacology

Volumn 44, Issue 5, 2003, Pages 555-561

  Scaccianoce, S ^a   Matrisciano, F ^a   Del Bianco, P ^a   Caricasole, A ^a,b   Di Giorgi Gerevini, V ^a   Cappuccio, I ^a   Melchiorri, D ^a,c   Battaglia, G ^c   Nicoletti, F ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Siena Biotech SpA   (Italy)

^c IRCCS NEUROMED   (Italy)

Author keywords

Corticosterone; Hypothalamic pituitary adrenal axis; Metabotropic glutamate receptors; Mice

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DIZOCILPINE; MESSENGER RNA; METABOTROPIC RECEPTOR; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN RELEASE; DRUG EFFECT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 0037382286     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(03)00027-3     Document Type: Article

References (30)

1. Auffrey C., Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNA from total myeloma tumour RNA. Eur J Biochem. 107:1980;303-314.
2. Brann D.W. Glutamate: a major excitatory transmitter in neuroendocrine regulation. Neuroendocrinology. 61:1995;213-225.
3. Bradbury M.W., Burden J., Hillhouse E.W., Jones M.T. Stimulation electrically and by acetylcholine of the rat hypothalamus in vitro. J Physiol. 239:1974;269-283.
4. Bruno V., Battaglia G., Copani A., D'Onofrio M., Di Iorio P., De Blasi A., Melchiorri D., Flor P.J., Nicoletti F. Metabotropic glutamate receptor subtypes as targets for neuorprotective drugs. J Cer Blood Flow Metabol. 21:2001;1013-1033.
5. Casabona G., Genazzani A.A., Di Stefano M., Sortino M.A., Nicoletti F. Developmental changes in the modulation of cyclic AMP formation by the metabotorpic glutamate receptor agonist 1S,3R-aminocyclopentane-1,3-dicarboxylic acid in brain slices. J Neurochem. 59:1992;1161-1163.
6. Cole R.L., Sawchenko P.E. Neurotransmitter regulation of cellular activation and neuropeptide gene expression in the paraventricular nucleus of the hippothalamus. J Neurosci. 22:2002;959-969.
7. Darlington D.N., Miyamoto M., Keil L.C., Dallman M.F. Paraventricular stimulation with glutamate elicits bradycardia and pituitary responses. Am J Physiol. 256:1989;112-119.
8. Farah J.M., Rao T.S., Mick S.J., Coyne K.E., Iyengar S. N-methyl-Daspartate treatment increases circulating adrenocorticotropin and luteinizing hormone in the rat. Endocrinology. 128:1991;1875-1880.
9. Gasparini F., Lingenhohl K., Stoehr N., Flor P.J., Heinrich M., Vranesic I., Biollaz M., Allgeier H., Heckendorn R., Urwyler S., Varney M.A., Johnson E.C., Hess S.D., Rao S.P., Sacaan A.I., Santori E.M., Velicelebi G., Kuhn R. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology. 38:1999;1493-1503.
10. Genazzani A.A., Casabona G., L'Episcopo M.R., Condorelli D.F., Dell'Albani P., Shnozaki H., Nicoletti F. Characterization of metabotropic glutamate receptors negatively linked to adenylyl cyclase in brain slices. Brain Res. 17:1993;132-138.
11. Jezova D., Oliver C., Jurcovicova J. Stimulation of adrenocorticotropin but not prolactin and catecholamine release by N-methyl-aspartic acid. Neuroendocrinology. 54:1991;488-492.
12. Johnson M.P., Kelly G., Chamberlan M. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. J Neuroendocrinol. 13:2001;670-677.
13. Kingston A.E., Ornstein P.L., Wright R.A., Johnson B.G., Mayne N.G., Burnett J.P., Belagaje R., Wu S., Schoepp D.D. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology. 37:1998;1-12.
14. Kocsic K., Kiss J., Gorcs T., Halasz B. Metabotropic glutamate receptors in vasopressin, CRF and VIP hypothalamic neurons. NeuroReport. 9:1998;4029-4033.
15. Lang C.H., Ajmal M. Metabolic, hormonal, and hemodynamic changes inducced by metabotropic excitatory amino acid agonist (IS, 3R)-ACPD. Am J Physiol. 268:1995;26-33.
16. Lee S., Rivier C., Torres G. Induction of c-fos and CRF mRNA by MK-801 in the parvocellular paraventricular nucleus of the rat hypothalamus. Brain Res Brain Res Mol. 24:1994;192-198.
17. Makara G.B., Stark E. Effect of intraventricular glutamate on ACTH release. Neuroendocrinology. 18:1975;213-216.
18. Molina P.E., Tepper P.J., Yousef K.A., Abumrad N.N., Lang C.H. Central NMDA enhances hepatic glucose output and non-insulin-mediated glucose uptake by a nonadrenergic mechanism. Brain Res. 634:1994;41-48.
19. Monn J.A., Valli M.J., Massey S.M., Hansen M.M., Kress T.J., Wepsiec J.P., Harkness A.R., Grutsch J.L. Jr., Wright R.A., Johnson B.G., Andis S.L., Kingston A.E., Tomlinson R., Lewis R., Griffey K.R., Tizzano J.P., Schoepp D.D. Synthesis, pharmacologica characterization and nolecular modeling of heterobicylic amino acids related to LY354740: identification of LY379268 and LY389795: two new potent, selective and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 42:1999;1027-1040.
20. Nakanishi S. Metabotropic glutamate receptor: synaptic transmission, modulation and plasticity. Neuron. 13:1994;1031-1037.
21. Nicoletti F., Bruno V., Copani A., Casabona G., Knopfel T. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. 19:1996;267-271.
22. Pin J.P., Duvoisin R. The metabotorpic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
23. Pompillo M., Scimonelli T., Duvilanski B.H., Celis M.E., Seilicovich A., Lasaga M. The activation of metabotorpic glutamate receptors differentially affects GABA and alpha-melanocyte-stimulating hormone release from the hypothalamus and the posterior pituitaty of male rats. Neurosci Lett. 19:2002;95-98.
24. Scaccianoce S., Di Sciullo A., Angelucci L. Age related changes in hypothalamo pituitary-adrenocortical axis activity in the rat. Neuroendocrinology. 52:1990;150-158.
25. Schoepp D.D., Jane D.E., Monn J.A. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 38:1999;1431-1476.
26. Spooren W.P., Gasparini F., Salt T.E., Kuhn R. Novel allosteric antagonists shed light on mGlu5 receptors and CNS disorders. Trends Pharmacol Sci. 22:2001;331-337.
27. Tokarev D., Jezova D. Effect of central administration of the non-NMDA receptor antagonist DNQX on ACTH and corticosterone release before and during immobilization stress. Meth Find Exp Clin Pharmacol. 19:1997;323-328.
28. Yousef K.A., Tepper P.G., Molina P.E., Abumdrad N.N., Lang C.H. Differential control of glucoregulatory hormone response and glucose metabolism by NMDA and kainate. Brain Res. 634:1994;131-140.
29. Van den Pol A.N., Romano C., Ghosh P. Metabotropic glutamate receptor mGluR5 subcellular distribution and developmental expression in hopothalamus. J Comp Neurol. 362:1995;134-150.
30. Ziegler D.R., Herman J.P. Local integration of glutamate signalling in the hipothalamic paraventricular region: regulation of glucocorticoid stress responses. Endocrinology. 141:2000;4801-4804.