Immature dendritic cells (DCs) use chemokines and intercellular adhesion molecule (ICAM)-1, but not DC-specific ICAM-3-grabbing nonintegrin, to stimulate CD4+ T cells in the absence of exogenous antigen

Journal of Immunology

Volumn 173, Issue 1, 2004, Pages 50-60

  Real, Eliana ^a   Kaiser, Andrew ^b   Raposo, Graça ^b   Amara, Ali ^b   Nardin, Alessandra ^b   Trautmann, Alain ^a   Donnadieu, Emmanuel ^a,c  

^a CNRS   (France)

^b INSTITUT PASTEUR   (France)

^c INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CALCIUM; CCL22 CHEMOKINE; CD209 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; CHEMOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 3; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PERTUSSIS TOXIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CALCIUM CURRENT; CELL MOTILITY; CELL POLARITY; CELLULAR IMMUNITY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMATURE DENTRITIC CELL; MEMORY CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 2942746516     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.1.50     Document Type: Article

References (38)

1. Moser, M. 2003. Dendritic cells in immunity and tolerance: do they display opposite functions? Immunity 19:5.
2. Scheinecker, C., R. McHugh, E. M. Shevach, and R. N. Germain. 2002. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 196:1079.
3. Wilson, N. S., D. El-Sukkari, G. T. Belz, C. M. Smith, R. J. Steptoe, W. R. Heath, K. Shortman, and J. A. Villadangos. 2003. Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 102:2187.
4. Hawiger, D., K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J. V. Ravetch, R. M. Steinman, and M. C. Nussenzweig. 2001. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med. 194:769.
5. Steinman, R. M., D. Hawiger, and M. C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685.
6. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198:235.
7. Nussenzweig, M. C., and R. M. Steinman. 1980. Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J. Exp. Med. 151:1196.
8. 2+ responses triggered in T cells by dendritic cells compared with B cells. J. Exp. Med. 188:1473.
9. Revy, P., M. Sospedra, B. Barbour, and A. Trautmann. 2001. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat. Immunol. 2:925.
10. Montes, M., D. McIlroy, A. Hosmalin, and A. Trautmann. 1999. Calcium responses elicited in human T cells and dendritic cells by cell-cell interaction and soluble ligands. [Published erratum appears in 1999 Int. Immunol. 11:1275.] Int. Immunol. 11:561.
11. Montes, M., D. McIlroy, A. Hosmalin, and A. Trautmann. 1999. Calcium responses elicited in human T cells and dendritic cells by cell-cell interaction and soluble ligands. [Published erratum appears in 1999 Int. Immunol. 11:1275.] Int. Immunol. 11:561.
12. Kondo, T., I. Cortese, S. Markovic-Plese, K. P. Wandinger, C. Carter, M. Brown, S. Leitman, and R. Martin. 2001. Dendritic cells signal T cells in the absence of exogenous antigen. Nat. Immunol. 2:932.
13. van Kooyk, Y., and T. B. Geijtenbeek. 2003. DC-SIGN: escape mechanism for pathogens. Nat. Rev. Immunol. 3:697.
14. Geijtenbeek, T. B., R. Torensma, S. J. van Vliet, G. C. van Duijnhoven, G. J. Adema, Y. van Kooyk, and C. G. Figdor. 2000. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100:575.
15. Wu, M., H. Fang, and S. T. Hwang. 2001. Cutting edge: CCR4 mediates antigen-primed T cell binding to activated dendritic cells. J. Immunol. 167:4791.
16. Bromley, S. K., and M. L. Dustin. 2002. Stimulation of naive T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. Immunology 106:289.
17. Boccaccio, C., S. Jacod, A. Kaiser, A. Boyer, J. P. Abastado, and A. Nardin. 2002. Identification of a clinical-grade maturation factor for dendritic cells. J. Immunother. 25:88.
18. Halary, F., A. Amara, H. Lortat-Jacob, M. Messerle, T. Delaunay, C. Houles, F. Fieschi, F. Arenzana-Seisdedos, J. F. Moreau, and J. Dechanet-Merville. 2002. Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. Immunity 17:653.
19. Donnadieu, E., G. Bismuth, and A. Trautmann. 1994. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr. Biol. 4:584.
20. Negulescu, P. A., T. B. Krasieva, A. Khan, H. H. Kerschbaum, and M. D. Cahalan. 1996. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4:421.
21. Sallusto, F., D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708.
22. Baba, M., O. Nishimura, N. Kanzaki, M. Okamoto, H. Sawada, Y. Iizawa, M. Shiraishi, Y. Aramaki, K. Okonogi, Y. Ogawa, et al. 1999. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. USA 96:5698.
23. + T cells. Eur. J. Immunol. 25:2285.
24. Miller, M. J., S. H. Wei, I. Parker, and M. D. Cahalan. 2002. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296:1869.
25. Miller, M. J., S. H. Wei, M. D. Cahalan, and I. Parker. 2003. Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy. Proc. Natl. Acad. Sci. USA 100:2604.
26. + T cell priming by dendritic cells in intact lymph nodes. Nat. Immunol. 4:579.
27. Luther, S. A., H. L. Tang, P. L. Hyman, A. G. Farr, and J. G. Cyster. 2000. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97:12694.
28. Gunzer, M., A. Schafer, S. Borgmann, S. Grabbe, K. S. Zanker, E. B. Brocker, E. Kampgen, and P. Friedl. 2000. Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13:323.
29. Vissers, J. L., F. C. Hartgers, E. Lindhout, M. B. Teunissen, C. G. Figdor, and G. J. Adema. 2001. Quantitative analysis of chemokine expression by dendritic cell subsets in vitro and in vivo. J. Leukocyte Biol. 69:785.
30. Laudanna, C., J. Y. Kim, G. Constantin, and E. Butcher. 2002. Rapid leukocyte integrin activation by chemokines. Immunol. Rev. 186:37.
31. del Pozo, M. A., C. Cabanas, M. C. Montoya, A. Ager, P. Sanchez-Mateos, and F. Sanchez-Madrid. 1997. ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes. J. Cell Biol. 137:493.
32. + T cell activation. J. Immunol. 164:5010.
33. Campbell, J. J., G. Haraldsen, J. Pan, J. Rottman, S. Qin, P. Ponath, D. P. Andrew, R. Warnke, N. Ruffing, N. Kassam, et al. 1999. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400:776.
34. + T cells represent major subsets of human peripheral blood memory T cells migrating in response to CCL1/I-309. Eur. J. Immunol. 32:3506.
35. Klein, L., K. Khazaie, and H. von Boehmer. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100:8886.
36. Randriamampita, C., G. Boulla, P. Revy, F. Lemaitre, and A. Trautmann. 2003. T cell adhesion lowers the threshold for antigen detection. Eur. J. Immunol. 33:1215.
37. Kassiotis, G., S. Garcia, E. Simpson, and B. Stockinger. 2002. Impairment of immunological memory in the absence of MHC despite survival of memory T cells. Nat. Immunol. 3:244.
38. Stefanova, I., J. R. Dorfman, and R. N. Germain. 2002. Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature 420:429.