Dual and opposing roles of ERK in regulating G1 and S-G 2/M delays in A549 cells caused by hyperoxia

Experimental Cell Research

Volumn 297, Issue 2, 2004, Pages 472-483

  Ko, Jen Chung ^a,b   Wang, Yi Ting ^a   Yang, Jia Ling ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b Hsinchu General Hospital   (Taiwan)

Author keywords

Cdk; Checkpoint; Cyclin; Cyclin dependent kinase; ERK; Extracellular signal regulated kinase; FCS; Fetal calf serum; Hyperoxia; MAPK; MAPK kinase; Mitogen activated protein kinase; MKK; p21; p21CIP1; p53; PBS; Phosphate buffered saline

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE; MITOGEN ACTIVATED PROTEIN KINASE; OXYGEN; PHOSPHOTRANSFERASE; PROTEIN P21; PROTEIN P53;

ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; HUMAN; HUMAN CELL; HYPEROXIA; INHIBITION KINETICS; LUNG ALVEOLUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STIMULATION; TIME;

EID: 2942726086     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2004.03.033     Document Type: Article

References (51)

1. Sherr C.J. Cancer cell cycles. Science. 274:1996;1672-1677
2. Pines J. Four-dimensional control of the cell cycle. Nat. Cell Biol. 1:1999;E73-E79
3. Bartek J., Lukas J. Pathways governing G1/S transition and their response to DNA damage. FEBS Lett. 490:2001;117-122
4. Agami R., Bernards R. Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle. Cancer Lett. 177:2002;111-118
5. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185
6. Kolch W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J. 351:2000;289-305
7. Roovers K., Assoian R.K. Integrating the MAP kinase signal into the G1 phase cell cycle machinery. BioEssays. 22:2000;818-826
8. Keenan S.M., Bellone C., Baldassare J.J. Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase. J. Biol. Chem. 276:2001;22404-22409
9. Lents N.H., Keenan S.M., Bellone C., Baldassare J.J. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. J. Biol. Chem. 277:2002;47469-47475
10. Meloche S. Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of p44mapk and p42mapk isoforms in the G1 phase and their inactivation at the G1/S transition. J. Cell. Physiol. 163:1995;577-588
11. Wright J.H., Munar E., Jameson D.R., Andreassen P.R., Margolis R.L., Seger R., Krebs E.G. Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 96:1999;11335-11340
12. Shapiro P.S., Vaisberg E., Hunt A.J., Tolwinski N.S., Whalen A.M., McIntosh J.R., Ahn N.G. Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J. Cell Biol. 142:1998;1533-1545
13. Zecevic M., Catling A.D., Eblen S.T., Renzi L., Hittle J.C., Yen T.J., Gorbsky G.J., Weber M.J. Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E. J. Cell Biol. 142:1998;1547-1558
14. Mantell L.L., Lee P.J. Signal transduction pathways in hyperoxia-induced lung cell death. Mol. Genet. Metab. 71:2000;359-370
15. Rancourt R.C., Staversky R.J., Keng P.C., O'Reilly M.A. Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-β signaling. Am. J. Physiol. 277:1999;L1172-L1178
16. WAF1/CIP1 expression in human bronchial smooth-muscle cells. Am. J. Respir. Cell Mol. Biol. 21:1999;395-402
17. WAF1/CIP1-independent Cdk2 inhibition in human carcinoma T47D-H3 cells. Exp. Cell Res. 256:2000;347-357
18. cip1/Waf1/Sdi1 protects against oxygen-induced toxicity. Toxicol. Sci. 63:2001;214-222
19. Waf1/Cip1/Sdi1 levels. Biochim. Biophys. Acta. 1538:2001;90-97
20. CIP1/WAF1 in growth of epithelial cells exposed to hyperoxia. Am. J. Physiol.: Lung. Cell Mol. Physiol. 280:2001;L617-L626
21. Corroyer S., Maitre B., Cazals V., Clement A. Altered regulation of G1 cyclins in oxidant-induced growth arrest of lung alveolar epithelial cells. Accumulation of inactive cyclin E-DCK2 complexes. J. Biol. Chem. 271:1996;25117-25125
22. O'Reilly M.A., Staversky R.J., Finkelstein J.N., Keng P.C. Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia. Am. J. Physiol.: Lung Cell. Mol. Physiol. 284:2003;L368-L375
23. Buckley S., Driscoll B., Barsky L., Weinberg K., Anderson K., Warburton D. ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2. Am. J. Physiol. 277:1999;L159-L166
24. Petrache I., Choi M.E., Otterbein L.E., Chin B.Y., Mantell L.L., Horowitz S., Choi A.M. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am. J. Physiol. 277:1999;L589-L595
25. Zhang X., Shan P., Sasidhar M., Chupp G.L., Flavell R.A., Choi A.M., Lee P.J. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am. J. Respir. Cell Mol. Biol. 28:2003;305-315
26. Parinandi N.L., Kleinberg M.A., Usatyuk P.V., Cummings R.J., Pennathur A., Cardounel A.J., Zweier J.L., Garcia J.G., Natarajan V. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am. J. Physiol.: Lung Cell. Mol. Physiol. 284:2003;L26-L38
27. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494
28. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:1998;18623-18632
29. Sherr C.J., Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1999;1501-1512
30. Persons D.L., Yazlovitskaya E.M., Pelling J.C. Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J. Biol. Chem. 275:2000;35778-35785
31. She Q.B., Chen N., Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J. Biol. Chem. 275:2000;20444-20449
32. Wang S., Shi X. Mechanisms of Cr(VI)-induced p53 activation: the role of phosphorylation, mdm2 and ERK. Carcinogenesis. 22:2001;757-762
33. Kastan M.B., Lim D.S. The many substrates and functions of ATM. Nat. Rev., Mol. Cell Biol. 1:2000;179-186
34. Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2001;2177-2196
35. Dumaz N., Meek D.W. Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J. 18:1999;7002-7010
36. Das K.C., Dashnamoorthy R. Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites. Am. J. Physiol.: Lung Cell. Mol. Physiol. 286:2004;L87-L97
37. Bulavin D.V., Saito S., Hollander M.C., Sakaguchi K., Anderson C.W., Appella E., Fornace A.J. Jr. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 18:1999;6845-6854
38. Buschmann T., Potapova O., Bar-Shira A., Ivanov V.N., Fuchs S.Y., Henderson S., Fried V.A., Minamoto T., Alarcon-Vargas D., Pincus M.R., Gaarde W.A., Holbrook N.J., Shiloh Y., Ronai Z. Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol. Cell. Biol. 21:2001;2743-2754
39. Lee S.W., Fang L., Igarashi M., Ouchi T., Lu K.P., Aaronson S.A. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. U. S. A. 97:2000;8302-8305
40. Tang D., Wu D., Hirao A., Lahti J.M., Liu L., Mazza B., Kidd V.J., Mak T.W., Ingram A.J. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 277:2002;12710-12717
41. Weber J.D., Raben D.M., Phillips P.J., Baldassare J.J. Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem. J. 326:1997;61-68
42. Pumiglia K.M., Decker S.J. Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. U. S. A. 94:1997;448-452
43. Macleod K.F., Sherry N., Hannon G., Beach D., Tokino T., Kinzler K., Vogelstein B., Jacks T. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev. 9:1995;935-944
44. Kato J.Y., Matsuoka M., Strom D.K., Sherr C.J. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14:1994;2713-2721
45. Desai D., Wessling H.C., Fisher R.P., Morgan D.O. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol. Cell. Biol. 15:1995;345-350
46. 1/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol. Cell. Biol. 19:1999;6183-6194
47. Waldman T., Lengauer C., Kinzler K.W., Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature. 381:1996;713-716
48. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 282:1998;1497-1501
49. Zwicker J., Muller R. Cell-cycle regulation of gene expression by transcriptional repression. Trends Genet. 13:1997;3-6
50. Bottazzi M.E., Buzzai M., Zhu X., Desdouets C., Brechot C., Assoian R.K. Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol. Cell. Biol. 21:2001;7607-7616
51. Jung M.S., Yun J., Chae H.D., Kim J.M., Kim S.C., Choi T.S., Shin D.Y. p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene. 20:2001;5818-5825