CD40L in autoimmunity and mucosally induced tolerance

Journal of Clinical Investigation

Volumn 109, Issue 2, 2002, Pages 171-173

  Kweon, Mi Na ^a   Kiyono, Hiroshi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ANIMAL MODEL; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL PROLIFERATION; CLONAL ANERGY; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; DENDRITIC CELL; GERMINAL CENTER; HYPERSENSITIVITY; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; IMMUNOSTIMULATION; MOUTH MUCOSA; NOSE MUCOSA; NOTE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0036155874     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214930     Document Type: Note

References (25)

1. Immune responses to dietary antigens: Oral tolerance
2. Oral tolerance, an active immunologic process mediated by multiple mechanisms
3. Oral tolerance: Mechanisms and therapeutic applications
4. Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals
5. Oral tolerance with copolymer 1 for the treatment of multiple sclerosis
6. Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route
7. Induction of autoimmune diabetes by oral administration of autoantigen
8. Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
9. Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions
10. Mice deficient for the CD40 ligand
11. Humoral immune responses in CD40 ligand-deficient mice
12. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
13. CTLA-4 is required for the induction of high dose oral tolerance
14. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
15. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
16. Peyer's patches are required for oral tolerance to proteins
17. Increased T cell autoreactivicy in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development
18. + regulatory T cells by oral antigen administration
19. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
20. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals
21. + T-helper and a T-killer cell
22. A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response
23. Dendritic cells and the control of immunity
24. Mucosal immunity and inflammation. I. Mucosal dendritic cells: Their specialized role in initiating T cell responses
25. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch