Two-step activation of T-cells, clonal expansion and subsequent Th1 cytokine production, is essential for the development of clinical autoimmune encephalomyelitis

European Journal of Immunology

Volumn 31, Issue 6, 2001, Pages 1800-1812

  Jee, Youngheun ^a   Matsumoto, Yoh ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Cytokine profile; Experimental autoimmune encephalomyelitis; Incomplete Freud's adjuvant; Pertussis toxin; TCR repertoire

Indexed keywords

ANTIGEN; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; MYELIN BASIC PROTEIN; PERTUSSIS TOXIN; PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMULSION; IMMUNE STATUS; IMMUNIZATION; LYMPHOCYTE CLONE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RAT STRAIN; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ANIMALS; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FREUND'S ADJUVANT; GUINEA PIGS; HEMATOPOIETIC STEM CELLS; IMMUNIZATION; INTERLEUKIN-12; LIPIDS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MYELIN BASIC PROTEINS; PERTUSSIS TOXIN; RATS; RATS, INBRED LEW; RECEPTORS, ANTIGEN, T-CELL; SPINAL CORD; T-LYMPHOCYTES; TH1 CELLS; VIRULENCE FACTORS, BORDETELLA;

EID: 0034975741     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200106)31:6<1800::AID-IMMU1800>3.0.CO;2-S     Document Type: Article

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