Tryptophan scanning mutagenesis of aromatic residues within the polymerase domain of HIV-1 reverse transcriptase: Critical role of Phe-130 for p51 function and second-site revertant restoring viral replication capacity

Virology

Volumn 324, Issue 2, 2004, Pages 400-411

  Olivares, Isabel ^a   Gutiérrez Rivas, Mónica ^a,b   López Galíndez, Cecilio ^a   Menéndez Arias, Luis ^b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b CSIC   (Spain)

Author keywords

Drug resistance; Fitness; HIV; Mutagenesis; Polymerase; Retrovirus; Reverse transcriptase

Indexed keywords

PARATHION; PHENYLALANINE; POLYPROTEIN; PROTEIN; PROTEIN P51; RNA DIRECTED DNA POLYMERASE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CELL CULTURE; CELL STRAIN COS1; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS MUTATION; VIRUS REPLICATION; WILD TYPE;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA-DIRECTED RNA POLYMERASES; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENYLALANINE; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; TEMPLATES, GENETIC; TRYPTOPHAN; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 2942704147     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2004.04.010     Document Type: Article

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