Failure of cortisone acetate treatment in congenital adrenal hyperplasia because of defective 11β-hydroxysteroid dehydrogenase reductase activity

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 4, 1999, Pages 1210-1213

  Nordenström, Anna ^a   Marcus, Claude ^a   Axelson, Magnus ^a   Wedell, Anna ^a   Ritzén, E Martin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; CORTISONE ACETATE; HYDROCORTISONE; PREGNANETRIOL; STEROID 21 MONOOXYGENASE;

CASE REPORT; CHILD; CONFERENCE PAPER; CONGENITAL ADRENAL HYPERPLASIA; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HUMAN; INTRON; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS;

EID: 0033307045     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.4.5584     Document Type: Conference Paper

References (33)

1. 11β-Hydroxysteroid dehydrogenase: Fact or fancy?
2. Medical and physiological aspects of the 11β-hydroxysteroid dehydrogenase system
3. Cortisol to cortisone: Glucocorticoid to mineralocorticoid
4. The human gene for 11β-hydroxysteroid dehydrogenase: Structure, tissue distribution and chromosomal localization
5. Clinical investigation of 11β-hydroxysteroid dehydrogenase
6. 'Liver-type' 11β-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells
7. 11β-Hydroxysteroid dehydrogenase is an exclusive 11β-reductase in primary cultures of rat hepatocytes: Effect of physicochemical and hormonal manipulations
8. 11β-Hydroxy-steroid dehydrogenase type 1 expression in 2S FAZA hepatoma cells is hormonally regulated: A model system for the study of hepatic glucocorticoid metabolism
9. Tissue localization of 11 β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor
10. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation
11. Hyperandrogenism in polycystic ovary syndrome
12. Update on congenital adrenal hyperplasia
13. Congenital adrenal hyperplasia
14. Mutational spectrum of the steroid 21-hydroxylase gene in Scandinavia. Implications for the genetic diagnosis and association with disease manifestation
15. Steroid 21-Hydroxylase deficiency: Genotype may not predict phenotype
16. Plasma cortisol delivery from oral cortisol and cortisone acetate: Relative bio-availability
17. A comparison of the three glucocorticoid suppressive regimes in adults with congenital adrenal hyperplasia
18. Pharmacokinetics and oral bioavailability of hydrocortisone
19. Variable efficacy of glucocorticoids in congenital adrenal hyperplasia
20. Vollkommen mannliche auBere Genitalentwicklung und Salzverlustsyndrom bei Madchen mit kongenitalem adrenogenitalem Syndrom
21. Serum levels of 4-androstene-3,17-dione in menstruating and postmenopausal women. Evaluation of a radioimmunoassay and correlation to bone mineral content and endometrial pathology
22. Orchidectomy or estrogen treatment in prostatic cancer: Effects on serum levels of adrenal androgens and related steroids
23. Analysis of profiles of conjugated steroids in urine by ion-exchange separation and gas chromatography-mass spectrometry
24. A possible defect in the inter-conversion between cortisone and cortisol in prepubertal patients with congenital adrenal hyperplasia receiving cortisone acetate therapy
25. Analysis of the promoter of the NAD+ dependent 11β-hydroxysteroid dehydrogenase (HSD11K) gene in JEG-3 human choriocarcinoma cells
26. Regulation of 11β-hydroxysteroid dehydrogenase type 1 in primary cultures of rat and human hepatocytes
27. 11β-hydroxysteroid dehydrogenase 1 in adipocytes: Expression is differentiation-dependent and hormonally regulated
28. Regulation of 11β-HSD by sex steroids in vivo: Further evidence for the existence of a second dehydrogenase in rat kidney
29. Sexual dimorphism of hepatic 11β-hydroxysteroid dehydrogenase in the rat: The role of growth hormone patterns
30. Sex- and tissue-specific regulation of 11β-hydroxysteroid dehydrogenase mRNA
31. Mineralocorticoid in the management of primary adrenocortical insufficiency
32. The role of plasma renin activity in evaluating the adequacy of mineralocorticoid replacement in primary adrenal insufficiency