α-2 agonists induce amnesia through activation of the Gi-protein signalling pathway

Neuroscience

Volumn 126, Issue 2, 2004, Pages 451-460

  Galeotti, N ^a   Bartolini, A ^a   Ghelardini, C ^a  

^a Dept Preclin and Clin Pharmacol ^*  (Italy)

Author keywords

analgesia; antisense oligonucleotide; antisense oligonucleotides; aODN; clonidine; degenerated antisense oligonucleotide; dODN; Gi proteins; guanabenz; ODN; oligonucleotide; pertussis toxin; PTX

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CLONIDINE; GUANABENZ; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; PERTUSSIS TOXIN; PROTEIN SUBUNIT;

ALPHA CHAIN; AMINO ACID SEQUENCE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; MEMORY DISORDER; MOTOR COORDINATION; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PASSIVE EUTHANASIA; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ADRENERGIC ALPHA-AGONISTS; AMNESIA; ANIMALS; AVOIDANCE LEARNING; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MALE; MICE; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA-2; SIGNAL TRANSDUCTION;

EID: 2942631203     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.04.001     Document Type: Article

References (45)

1. Capaccioli S., Di Pasquale G., Mini E., Mazzei T., Quattrone A. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Biochem Biophys Res Comm. 107:1993;818-825
2. Chou J.C., Lee E.H. Differential involvement of hippocampal G-protein subtypes in the memory process of rats. Neuroscience. 64:1995;5-15
3. 2 c2 mrna in multiple tissues. Mol Pharmacol. 44:1993;70-75
4. Fowler C.J., Cowburn R.F., Garlind A., Winbland B., O'Neill C. Disturbances in signal transduction mechanisms in Alzheimer's disease. Mol Cell Biochem. 149-150:1995;287-292
5. α subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice. Neuropharmacology. 38:1999;1861-1873
6. Gasic S., Green A. Gi down-regulation and heterologous desensitization in adipocytes after treatment with the alpha 2-agonist UK 14304. Biochem Pharmacol. 49:1995;785-790
7. Genkova-Papasova M., Lazarova-Bakurova M. Influence of nootropic drugs on the memory-impairing effect of diethyldithiocarbamate and clonidine in "step-down" passive avoidance in albino rats. Acta Physiol Pharmacol Bulg. 14:1988;36-41
8. Genkova-Papasova M., Petkova-Petkova B., Lazarova-Bakurova M., Boyanova E., Staneva-Stoytcheva D. Effects of flunarizine and nitrendipine on electroconvulsive shock- and clonidine-induced amnesia. Pharmacol Biochem Behav. 56:1997;583-587
9. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol Chemother. 12:1957;12-15
10. Hall J.E., Uhrich T.D., Ebert T.J. Sedative, analgesic and cognitive effects of clonidine infusions in humans. Br J Anaest. 86:2001;5-11
11. Hall J.E., Uhrich T.D., Barney J.A., Arain S.R., Ebert T.J. Sedative, amnestic, and analgesic properties of small-dose dexmetedomidine infusions. Anesth Analg. 90:2000;699-705
12. Harrison J.K., Pearson W.R., Lynch K.R. Molecular characterization of alpha 1- and alpha 2-adrenoceptors. Trends Pharmacol Sci. 12:1991;62-67
13. Hawkins M., Monti J.M. Effects of pretreatment with 6-hydroxydopamine or noradrenergic receptor blockers on the clonidine-induced disruption of conditioned avoidance responding. Eur J Pharmacol. 58:1979;53-58
14. Jäkälä P., Riekkinen M., Sirvio J., Koivisto E., Kejonen K., Vanhanen M., Riekkinen P. Jr. Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology. 20:1999;460-470
15. Jarvik M.E., Kopp R. An improved one-trial passive avoidance learning situation. Psychol Rep. 21:1967;221-224
16. 2 adrenergic receptor agonists. Pain. 87:2000;181-191
17. Katada T., Ui M. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP ribosilation of a membrane protein. Proc Natl Acad Sci USA. 79:1982;3129-3133
18. Khan Z.P., Ferguson C.N., Jones R.M. α-2 And imidazoline receptor agonists Their pharmacological and therapeutical role. Anaesthesia. 54:1999;146-165
19. Kleuss C., Hescheler J., Ewel C., Rosenthal W., Schultz G., Wittig B. Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature. 353:1991;43-48
20. Kostowski W., Plaznik A., Pucilowski O. Effect of chronic clonidine treatment and lesion of the locus coeruleus on the conditioned avoidance behavior in rats. Pol J Pharmacol Pharm. 32:1980;305-312
21. Kurose H., Regan J.W., Caron M.G., Lefkowitz R.J. Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry. 30:1991;3335-3341
22. 2+ channels in rat portal vein myocytes. Pflugers Arch. 430:1995;590-592
23. McClue S.J., Milligan G. Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins Studies with site-directed antisera. Mol Pharmacol. 40:1991;627-632
24. 2-adrenoceptor-subtype function. Trends Pharmacol Sci. 18:1997;211-219
25. Muller U. Prolonged activation of cAMP-dependent protein kinase during conditioning induces long-term memory in honeybees. Neuron. 27:2000;156-168
26. 2a adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 358:1998;197-206
27. Raffa R.B., Martinez R.P., Connelly C.D. G-protein antisense oligodeoxynucleotides and μ-opioid supraspinal antinociception. Eur J Pharmacol. 258:1994;R5-R7
28. Riekkinen M., Laakso M.P., Jäkälä P. Clonidine impairs sustained attention and memory in Alzheimer's disease. Neuroscience. 92:1999;975-982
29. 2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol. 32:1993;243-279
30. Rymer D.L., Good T.A. The role of G protein activation in the toxicity of amyloidogenic Aβ(1-40), Aβ(25-35), and bovine calcitonin. J Biol Chem. 276:2001;2523-2530
31. Sanchez-Blazquez P., Garzon J. Delta opioid subtypes activates inositol-signaling pathways in the production of antinociception. J Pharmacol Exp Ther. 285:1998;820-827
32. Sanchez-Blazquez P., Garcia-Espana A., Garzon J. In vivo injection of oligodeoxynucleotides to Gα subunits and supraspinal evoked by mu and delta opioid agonists. J Pharmacol Exp Ther. 275:1995;1590-1596
33. Sanchez-Blazquez P., Rodriguez-Diaz M., DeAntonio I., Garzon J. Endomorphin-1 and endomorphin-2 show differences in their activation of μ opioid receptor-regulated G proteins in supraspinal antinociception in mice. J Pharmacol Exp Ther. 291:1999;12-18
34. Scahill L., Chappell P.B., Kim Y.S., Schultz R.T., Katsovich L., Shepherd E., Arnsten A.F.T., Cohen D.J., Leckman J.F. Guanfacine in the treatment of children with tic disorders and ADHD A placebo-controlled study. Am J Psychiatry. 158:2001;1067-1074
35. Schaak S., Cussac D., Cayla C., Devedjian J.C., Guyot R., Paris H., Denis C. Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells. Gut. 47:2000;242-250
36. Schnecko A., Witte K., Bohl J., Ohm T., Lemmer B. Adenylyl cyclase activity in Alzheimer's disease brain Stimulatory and inhibitory signal transduction pathways are differently affected. Brain Res. 644:1994;291-296
37. Shanahan C., Gibson G.E., Cowburn R.F., Johnston J.A., Wiehager B., Lannfelt L., O'Neill C. G protein subunit levels in fibroblasts from familial Alzheimer's disease patients Lower levels of high molecular weight gs alpha isoform in patients with decreased β-adrenergic receptor stimulated camp formation. Neurosci Lett. 232:1997;33-36
38. Silva A.J., Kogan J.H., Frankland P.W., Kida S. CREB and memory. Annu Rev Neurosci. 21:1998;127-148
39. Simon M.I., Strathman M.P., Gautman N. Diversity of G proteins in signal transduction. Science. 252:1991;802-808
40. Soomets U., Mahlapuu R., Tehranian R., Jarvet J., Karelson E., Zilmer M., Iverfeldt K., Zorko M., Graslund A., Langel U. Regulation of GTPase and adenylate cyclase activity by amyloid β-peptide and its fragments in rat brain tissue. Brain Res. 850:1999;179-188
41. Sprang S.R. G-protein mechanisms Insights from structural analysis. Annu Rev Biochem. 66:1997;639-668
42. van Zwieten P.A. Centrally acting antihypertensive drugs Present and future. Clin Exp Hypertens. 21:1999;859-873
43. Vaught J., Pelley K., Costa L.G., Sether P., Enna S.J. A comparison of the antinociceptive responses to GABA-receptor agonists THIP and baclofen. Neuropharmacology. 24:1985;211-216
44. Wong Y.H., Conklin B.R., Bourne H.R. Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science. 255:1992;339-342
45. Zhang H.T., Crissman A.M., Dorairaj N.R., Chandler L.J., O'Donnell J.M. Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism. Neuropsychopharmacology. 23:2000;198-204