Opposing effects of cyclooxygenase-2 selective inhibitors on oxygen-glucose deprivation-induced neurotoxicity

European Journal of Pharmacology

Volumn 493, Issue 1-3, 2004, Pages 45-55

  Gendron, Tania F ^a,b   Brunette, Eric ^a   Mealing, Geoffrey A R ^b   Nguyen, Adele ^a   Tauskela, Joseph S ^a   Morley, Paul ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Ca2+; Cyclooxygenase 2; Excitotoxicity; NMDA; Oxygen glucose deprivation; Primary cortical culture

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CALCIUM ION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; GLUTAMIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; FETUS; HYPOGLYCEMIA; HYPOXIA; MOUSE; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; ANOXIA; CALCIUM; CANADA; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOSOL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENZYME INDUCTION; EXTRACELLULAR SPACE; GLUCOSE METABOLISM DISORDERS; GLUTAMATES; MICE; MICE, INBRED C57BL; NEUROTOXICITY SYNDROMES; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SULFONAMIDES; TIME FACTORS;

EID: 2942606403     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.04.026     Document Type: Article

References (39)

1. Baik E.J., Kim E.J., Lee S.H., Moon C. Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. Brain Res. 843:1999;118-129
2. 2+-dependent glutamate release in astrocytes. Nature. 391:1998;281-285
3. Black M.A., Tremblay R., Mealing G., Ray R., Durkin J.P., Whitfield J.F., Blosser J., Morley P. N-methyl-D-aspartate- or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR. J. Neurochem. 65:1995;2170-2177
4. Bozza P.T., Pacheco P., Yu W., Weller P.F. NS-398: cyclooxygenase-2 independent inhibition of leukocyte priming for lipid body formation and enhanced leukotriene generation. Prostaglandins Leukot. Essent. Fat. Acids. 67:2002;237-244
5. Caggiano A.O., Breder C.D., Kraig R.P. Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression. J. Comp. Neurol. 376:1996;447-462
6. Candelario-Jalil E., Ajamieh H.H., Sam S., Martinez G., Leon Fernandez O.S. Nimesulide limits kainate-induced oxidative damage in the rat hippocampus. Eur. J. Pharmacol. 390:2000;295-298
7. Carlson N.G. Neuroprotection of cultured cortical neurons mediated by the cyclooxygenase-2 inhibitor APHS can be reversed by a prostanoid. J. Neurosci. Res. 71:2003;79-88
8. Chen J., Marsh T., Zhang J.S., Graham S.H. Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. NeuroReport. 6:1995;245-248
9. Choi D.W., Maulucci-Gedde M., Kriegstein A.R. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7:1987;357-368
10. Cole D.J., Patel P.M., Reynolds L., Drummond J.C., Marcantonio S. Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume. J. Pharmacol. Exp. Ther. 266:1993;1713-1717
11. Collaço-Moraes Y., Aspey B., Harrison M., de Belleroche J. Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;1366-1372
12. DeWitt D.L. Cox-2-selective inhibitors: the new super aspirins. Mol. Pharmacol. 55:1999;625-631
13. Gendron T.F., Mealing G.A., Paris J., Lou A., Edwards A., Hou S.T., MacManus J.P., Hakim A.M., Morley P. Attenuation of neurotoxicity in cortical cultures and hippocampal slices from E2F1 knockout mice. J. Neurochem. 78:2001;316-324
14. 2+-independent mechanisms of neuronal injury. J. Neurosci. 13:1993;3510-3524
15. Greig G.M., Francis D.A., Falgueyret J.P., Ouellet M., Percival M.D., Roy P., Bayly C., Mancini J.A., O'Neill G.P. The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs. Mol. Pharmacol. 52:1997;829-838
16. Habib A., Créminon C., Frobert Y., Grassi J., Pradelles P., Maclouf J. Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2. J. Biol. Chem. 268:1993;23448-23454
17. Hara K., Kong D.L., Sharp F.R., Weinstein P.R. Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. Neurosci. Lett. 256:1998;53-56
18. Hewett S.J., Uliasz T.F., Vidwans A.S., Hewett J.A. Cyclooxygenase-2 contributes to N-methly-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J. Pharmacol. Exp. Ther. 293:2000;417-425
19. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., Ross E.M. Reduced susceptibility to ischemic injury and NMDA mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 98:2001;1294-1299
20. Kaufmann W.E., Worley P.F., Pegg J., Bremer M., Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U. S. A. 93:1996;2317-2321
21. Kelley K.A., Ho L., Winger D., Freire-Moar J., Borelli C.B., Aisen P.S., Pasinetti G.M. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am. J. Pathol. 155:1999;995-1004
22. Mealing G.A., Lanthorn T.H., Small D.L., Murray R.J., Mattes K.C., Comas T.M., Morley P. Structural modifications to an N-methyl-D-aspartate receptor antagonist result in large differences in trapping block. J. Pharmacol. Exp. Ther. 297:2001;906-914
23. Miettinen S., Fusco F.R., Yrjanheikki J., Keinanen R., Hirvonen T., Roivainen R., Narhi M., Hokfelt T., Koistinaho J. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. Proc. Natl. Acad. Sci. U. S. A. 94:1997;6500-6505
24. Mirjany M., Ho L., Pasinetti G.M. Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. J. Pharmacol. Exp. Ther. 301:2002;494-500
25. Mukherjee D., Nissen S.E., Topol E.J. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA. 286:2001;954-959
26. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. U. S. A. 95:1998;10954-10959
27. Nogawa S., Zhang F., Ross M.E., Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17:1997;2746-2755
28. Ohtsuki T., Kitagawa K., Yamagata K., Mandai K., Mabuchi T., Matsushita K., Yanagihara T., Matsumoto M. Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia. Brain Res. 736:1996;353-356
29. Pepicelli O., Fedele E., Bonanno G., Raiteri M., Ajmone-Cat M.A., Greco A., Levi G., Minghetti L. In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. J. Neurochem. 81:2002;1028-1034
30. Planas A.M., Soriano M.A., Rodriguez-Farre E., Ferrer I. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci. Lett. 200:1995;187-190
31. Rosenstock M., Danon A., Rimon G. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity. Biochim. Biophys. Acta. 1440:1999;127-137
32. Saeed S.A., Afzal M.N., Shah B.H. Dual effects of nimesulide, a COX-2 inhibitor, in human platelets. Life Sci. 63:1998;1835-1841
33. Sugimoto K., Iadecola C. Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. Brain Res. 960:2003;273-276
34. Tauskela J.S., Chakravarthy B.R., Murray C.L., Wang Y., Comas T., Hogan M., Hakim A., Morley P. Evidence from cultured rat cortical neurons of differences in the mechanism of ischemic preconditioning of brain and heart. Brain Res. 827:1999;143-151
35. Tauskela J.S., Comas T., Hewitt K., Monette R., Paris J., Hogan M., Morley P. Cross-tolerance to otherwise lethal N-methyl-D-aspartate and oxygen-glucose deprivation in preconditioned cortical cultures. Neuroscience. 107:2001;571-584
36. Tauskela J.S., Brunette E., Monette R., Comas T., Morley P. Preconditioning of cortical neurons by oxygen-glucose deprivation: tolerance induction through abbreviated neurotoxic signaling. Am. J. Physiol., Cell Physiol. 285:2003;C899-C911
37. Vartiainen N., Huang C.Y., Salminen A., Goldsteins G., Chan P.H., Koistinaho J. Piroxicam and NS-398 rescue neurones from hypoxia/reoxygenation damage by a mechanism independent of cyclo-oxygenase inhibition. J. Neurochem. 76:2001;480-489
38. Xiang Z., Ho L., Valdellon J., Borchelt D., Kelley K., Spielman L., Aisen P.S., Pasinetti G.M. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging. 23:2002;327-334
39. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 11:1993;371-386