HhaI DNA methyltransferase uses the protruding Gln237 for active flipping of its target cytosine

Structure

Volumn 12, Issue 6, 2004, Pages 1047-1055

  Daujotyte, Dalia ^a   Serva, Saulius ^a,c   Vilkaitis, Giedrius ^a,d   Merkiene, Egle ^a   Venclovas, Česlovas ^a,b   Klimašauskas, Saulius ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE; CYTOSINE; DNA B; DNA METHYLTRANSFERASE; GLYCINE; GLYCINE 237; GUANINE; METHYLTRANSFERASE; ORPHAN DRUG; PROTEIN HHAL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; DNA BINDING; DNA HELIX; DNA MODIFICATION; HYDROGEN BOND; KINETICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FUNCTION;

2-AMINOPURINE; BASE PAIRING; CATALYSIS; CYTOSINE; DEUTERIUM; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMINE; HYDROGEN; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC); SOFTWARE; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; TIME FACTORS;

EID: 2942562870     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2004.04.007     Document Type: Article

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