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1
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20744456789
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Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
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Merrifield B. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc. 85:1963;2149-2153
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J Am Chem Soc
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Merrifield, B.1
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2
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0014772602
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Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
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Kaiser E., Colescott R.L., Bossinger C.D., Cook P.I. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal Biochem. 34:1970;595-598
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Anal Biochem
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Kaiser, E.1
Colescott, R.L.2
Bossinger, C.D.3
Cook, P.I.4
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3
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33845556076
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Synthesis of deoxyoligonucleotides on a solid support
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Matteucci M.D., Caruthers M.H. Synthesis of deoxyoligonucleotides on a solid support. J Am Chem Soc. 103:1981;3185-3191
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J Am Chem Soc
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Matteucci, M.D.1
Caruthers, M.H.2
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4
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2942608301
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Monitoring of solid-phase peptide synthesis by potenometric titration of samples
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Schou O. Monitoring of solid-phase peptide synthesis by potenometric titration of samples. Acta Chem Scand B. 30:1976;991-993
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Acta Chem Scand B
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Schou, O.1
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5
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37049074891
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Feedback control in organic synthesis. A system for solid phase peptide synthesis with true automation
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Cameron L, Meldal M, Sheppard RC: Feedback control in organic synthesis. A system for solid phase peptide synthesis with true automation. Chem Commun 1987:270-272.
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(1987)
Chem Commun
, pp. 270-272
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Cameron, L.1
Meldal, M.2
Sheppard, R.C.3
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6
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37049090642
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Peptide synthesis. Part 13. Feedback control in solid phase synthesis. Use of fluorenylmethoxycarbonyl amino acid 3,4-dihydro- 4-oxo-1,2,3- benzotriazin-3-yl esters in a fully automated system
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Cameron LR, Holder JL, Meldal M, Sheppard RC: Peptide synthesis. Part 13. Feedback control in solid phase synthesis. Use of fluorenylmethoxycarbonyl amino acid 3, 4-dihydro- 4-oxo-1, 2, 3-benzotriazin-3-yl esters in a fully automated system. J Chem Soc Perkin Trans 1 1988:2895-2901.
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(1988)
J Chem Soc Perkin Trans 1
, pp. 2895-2901
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Cameron, L.R.1
Holder, J.L.2
Meldal, M.3
Sheppard, R.C.4
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7
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37049089203
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Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin- 3-yl esters of fluorenylmethoxycarbonyl amino acids as self- indicating reagents for solid phase peptide synthesis
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Atherton E, Jill LH, Meldal M, Sheppard RC, Valerio RM: Peptide synthesis. Part 12. 3, 4-Dihydro-4-oxo-1, 2, 3-benzotriazin- 3-yl esters of fluorenylmethoxycarbonyl amino acids as self- indicating reagents for solid phase peptide synthesis. J Chem Soc Perkin Trans 1 1988:2887-2894.
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(1988)
J Chem Soc Perkin Trans 1
, pp. 2887-2894
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Atherton, E.1
Jill, L.H.2
Meldal, M.3
Sheppard, R.C.4
Valerio, R.M.5
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8
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0001151375
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Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator
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Krchnák V., Vagner J., Safar P., Lebl M. Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator. Collect Czech Chem Commun. 53:1988;2542-2548
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Collect Czech Chem Commun
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Krchnák, V.1
Vagner, J.2
Safar, P.3
Lebl, M.4
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9
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0025893762
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General method for rapid synthesis of multicomponent peptide mixtures
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Furka A., Sebestyen F., Asgedom M., Dibo G. General method for rapid synthesis of multicomponent peptide mixtures. Int J Pept Protein Res. 37:1991;487-493
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Int J Pept Protein Res
, vol.37
, pp. 487-493
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Furka, A.1
Sebestyen, F.2
Asgedom, M.3
Dibo, G.4
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10
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0026419328
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A new type of synthetic peptide library for identifying ligand- binding activity
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Lam K.S., Salmon S.E., Hersh E.M., Hruby V.J., Kazmierski W.M., Knapp R.J. A new type of synthetic peptide library for identifying ligand- binding activity. Nature. 354:1991;82-84
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Nature
, vol.354
, pp. 82-84
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Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
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11
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0028264809
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Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity
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Meldal M., Svendsen I., Breddam K., Auzanneau F-I. Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity. Proc Natl Acad Sci USA. 91:1994;3314-3318
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(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3314-3318
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Meldal, M.1
Svendsen, I.2
Breddam, K.3
Auzanneau, F.-I.4
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12
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0030891637
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Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides
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Del Nery E., Juliano M.A., Meldal M., Svendsen I., Scharfstein J., Walmsley A., Juliano L. Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides. Biochem J. 323:1997;427-433
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(1997)
Biochem J
, vol.323
, pp. 427-433
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Del Nery, E.1
Juliano, M.A.2
Meldal, M.3
Svendsen, I.4
Scharfstein, J.5
Walmsley, A.6
Juliano, L.7
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13
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0035946413
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Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana
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Alves L.C., St Hilaire P.M., Meldal M., Sanderson S.J., Mottram J.C., Coombs G.H., Juliano L., Juliano M.A. Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana. Mol Biochem Parasitol. 114:2001;81-88
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Mol Biochem Parasitol
, vol.114
, pp. 81-88
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Alves, L.C.1
St Hilaire, P.M.2
Meldal, M.3
Sanderson, S.J.4
Mottram, J.C.5
Coombs, G.H.6
Juliano, L.7
Juliano, M.A.8
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14
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0033223445
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Fluorescent-quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificity
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St Hilaire P.M., Willert M., Juliano M.A., Juliano L., Meldal M. Fluorescent-quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificity. J Comb Chem. 1:1999;509-523
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(1999)
J Comb Chem
, vol.1
, pp. 509-523
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St Hilaire, P.M.1
Willert, M.2
Juliano, M.A.3
Juliano, L.4
Meldal, M.5
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15
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34247146066
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Direct visualization of enzyme inhibitors using a portion mixing inhibitor library containing a quenched fluorogenic peptide substrate. 1: Inhibitors for subtilisin Carlsberg
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Meldal M, Svendsen I: Direct visualization of enzyme inhibitors using a portion mixing inhibitor library containing a quenched fluorogenic peptide substrate. 1: Inhibitors for subtilisin Carlsberg. J Chem Soc Perkin Trans 1 1995:1591-1596.
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(1995)
J Chem Soc Perkin Trans 1
, pp. 1591-1596
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Meldal, M.1
Svendsen, I.2
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16
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0032037456
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Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L
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Meldal M., Svendsen I., Juliano L., Juliano M.A., Del Nery E., Scharfstein J. Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L. J Pept Sci. 4:1998;83-91
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(1998)
J Pept Sci
, vol.4
, pp. 83-91
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Meldal, M.1
Svendsen, I.2
Juliano, L.3
Juliano, M.A.4
Del Nery, E.5
Scharfstein, J.6
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17
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0034323969
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Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors
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Buchardt J., Schiødt C.B., Krog-Jensen C., Delaisse J-M., Foged N.T., Meldal M. Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors. J Comb Chem. 2:2000;624-638
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(2000)
J Comb Chem
, vol.2
, pp. 624-638
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Buchardt, J.1
Schiødt, C.B.2
Krog-Jensen, C.3
Delaisse, J.-M.4
Foged, N.T.5
Meldal, M.6
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18
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2942603600
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Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid phase
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Peptides for the New Millennium, Edited by Fields GB, Tam JP, Barany G. Dordrecht: Kluwer Academic Publishers
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Buchardt J, Schiødt CB, Ferreras M, Foged NT, Delaissé J-M, Meldal M: Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid phase. In Peptides For the New Millennium, Proc 16th Am Pept Symp 1999. Edited by Fields GB, Tam JP, Barany G. Dordrecht: Kluwer Academic Publishers; 2000:443-444.
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(2000)
Proc 16th Am Pept Symp 1999
, pp. 443-444
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Buchardt, J.1
Schiødt, C.B.2
Ferreras, M.3
Foged, N.T.4
Delaissé, J.-M.5
Meldal, M.6
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19
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0034942772
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Phosphinic peptide inhibitors of macrophage metalloelastase (MMP-12). Selectivity and mechanism of binding
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Schiødt C.B., Buchardt J., Terp G.E., Christensen U., Brink M., Larsen Y.B., Meldal M., Foged N.T. Phosphinic peptide inhibitors of macrophage metalloelastase (MMP-12). Selectivity and mechanism of binding. Curr Med Chem. 8:2001;967-976
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(2001)
Curr Med Chem
, vol.8
, pp. 967-976
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Schiødt, C.B.1
Buchardt, J.2
Terp, G.E.3
Christensen, U.4
Brink, M.5
Larsen, Y.B.6
Meldal, M.7
Foged, N.T.8
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20
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0242551201
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Solid phase combinatorial library of 1,3-azole containing peptides for the discovery of matrix metallo proteinase inhibitors
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Christensen C., Schiødt C.B., Foged N.T., Meldal M. Solid phase combinatorial library of 1, 3-azole containing peptides for the discovery of matrix metallo proteinase inhibitors. Combinatorial Science. 7:2003;754-766
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(2003)
Combinatorial Science
, vol.7
, pp. 754-766
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Christensen, C.1
Schiødt, C.B.2
Foged, N.T.3
Meldal, M.4
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21
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0038700605
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Solid phase combinatorial library of norstatine-type isosters by the nitroaldol reaction
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Willert M., Benito J.M., Meldal M. Solid phase combinatorial library of norstatine-type isosters by the nitroaldol reaction. J Comb Chem. 5:2003;91-101
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(2003)
J Comb Chem
, vol.5
, pp. 91-101
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Willert, M.1
Benito, J.M.2
Meldal, M.3
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22
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0035458539
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A combinatorial library of peptide isosters based on Diels-Alder reactions: Identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana
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Graven Sams A., St. Hilaire P.M., Sanderson S.J., Mottram J.C., Coombs G.H., Meldal M. A combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicana. J Comb Chem. 3:2001;441-452
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(2001)
J Comb Chem
, vol.3
, pp. 441-452
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Graven Sams, A.1
St. Hilaire, P.M.2
Sanderson, S.J.3
Mottram, J.C.4
Coombs, G.H.5
Meldal, M.6
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23
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2542542164
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Combinatorial library of peptidotriazoles: Identification of novel [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease
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in press.
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Tornøe CW, Sanderson SJ, Mottram JC, Coombs GH, Meldal M: Combinatorial library of peptidotriazoles: identification of novel [1, 2, 3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease. J Comb Chem 2004, in press.
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(2004)
J Comb Chem
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Tornøe, C.W.1
Sanderson, S.J.2
Mottram, J.C.3
Coombs, G.H.4
Meldal, M.5
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25
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0000847671
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Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: A comparison of PEG-cross-linked and PEG-grafted resins
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Grötli M., Gotfredsen C.H., Rademann J., Buchardt J., Clark A.J., Duus J.Ø., Meldal M. Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: a comparison of PEG-cross-linked and PEG-grafted resins. J Comb Chem. 2:2000;108-119
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(2000)
J Comb Chem
, vol.2
, pp. 108-119
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Grötli, M.1
Gotfredsen, C.H.2
Rademann, J.3
Buchardt, J.4
Clark, A.J.5
Duus J.Ø6
Meldal, M.7
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26
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0026704473
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PEGA: A flow stable polyethylene glycol dimethyl acrylamide copolymer for solid phase synthesis
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Meldal M. PEGA: A flow stable polyethylene glycol dimethyl acrylamide copolymer for solid phase synthesis. Tetrahedron Lett. 33:1992;3077-3080
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(1992)
Tetrahedron Lett
, vol.33
, pp. 3077-3080
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Meldal, M.1
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27
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0033575063
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SPOCC: Resin for solid phase organic chemistry and enzyme reactions
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Rademann J., Grötli M., Meldal M., Bock K. SPOCC: Resin for solid phase organic chemistry and enzyme reactions. J Am Chem Soc. 121:1999;5459-5466
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(1999)
J Am Chem Soc
, vol.121
, pp. 5459-5466
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Rademann, J.1
Grötli, M.2
Meldal, M.3
Bock, K.4
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28
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0033526393
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A chemosensor-based approach to catalyst discovery in solution and on solid support
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This paper introduces the use of the very general proton activated fluorescence 'one bead two compound' assay to monitor catalyzed substitution reactions in split mix catalyst libraries.
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Copeland G.T., Miller S.J. A chemosensor-based approach to catalyst discovery in solution and on solid support. J Am Chem Soc. 121:1999;4306-4307 This paper introduces the use of the very general proton activated fluorescence 'one bead two compound' assay to monitor catalyzed substitution reactions in split mix catalyst libraries.
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(1999)
J Am Chem Soc
, vol.121
, pp. 4306-4307
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Copeland, G.T.1
Miller, S.J.2
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29
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0034807976
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Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence-based activity assay: An approach to kinetic resolution of secondary alcohols of broad structural scope
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Copeland G.T., Miller S.J. Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence-based activity assay: an approach to kinetic resolution of secondary alcohols of broad structural scope. J Am Chem Soc. 123:2001;6496-6502
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(2001)
J Am Chem Soc
, vol.123
, pp. 6496-6502
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Copeland, G.T.1
Miller, S.J.2
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30
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0037070622
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Asymmetric azidation - Cycloaddition with open-chain peptide based catalysts. A sequential enantioselective route to triazoles
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Guerin D.J., Miller S.J. Asymmetric azidation - cycloaddition with open-chain peptide based catalysts. A sequential enantioselective route to triazoles. J Am Chem Soc. 124:2002;2134-2136
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(2002)
J Am Chem Soc
, vol.124
, pp. 2134-2136
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Guerin, D.J.1
Miller, S.J.2
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31
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0033517679
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Discovery of novel catalysts for allylic alkylation with a visual colorimetric assay
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This efficient catalyst assay for C-C bond formation is performed in solution; however, it could easily be transferred to solid support.
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Lavastre O., Morken J.P. Discovery of novel catalysts for allylic alkylation with a visual colorimetric assay. Angew Chem Int Ed. 38:2004;3163-3165 This efficient catalyst assay for C-C bond formation is performed in solution; however, it could easily be transferred to solid support.
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(2004)
Angew Chem Int Ed
, vol.38
, pp. 3163-3165
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Lavastre, O.1
Morken, J.P.2
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32
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0038555590
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Catalyst-substrate coimmobilization: A strategy for catalysts discovery in split-and-mix libraries
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This paper describes a colored reactant in solution being immobilized to a solid phase substrate by different catalysts on each bead. The paper describes esterification catalysis and the rates and selectivities call for some optimization of catalyst structure.
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Krattiger P., McCarthy C., Pfaltz A., Wennemers H. Catalyst-substrate coimmobilization: a strategy for catalysts discovery in split-and-mix libraries. Angew Chem Int Ed. 42:2003;1722-1724 This paper describes a colored reactant in solution being immobilized to a solid phase substrate by different catalysts on each bead. The paper describes esterification catalysis and the rates and selectivities call for some optimization of catalyst structure.
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(2003)
Angew Chem Int Ed
, vol.42
, pp. 1722-1724
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Krattiger, P.1
McCarthy, C.2
Pfaltz, A.3
Wennemers, H.4
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33
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0141608199
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Dyad beads and the combinatorial discovery of catalysts
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Lingard I, Bhalay G, Bradley M: Dyad beads and the combinatorial discovery of catalysts. Chem Commun 2003:2310-3211.
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Chem Commun
, pp. 2310-3211
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Lingard, I.1
Bhalay, G.2
Bradley, M.3
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34
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0030680249
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Encoding strategies in combinatorial chemistry
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Czarnik A.W. Encoding strategies in combinatorial chemistry. Proc Natl Acad Sci USA. 94:1997;12738-12739
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(1997)
Proc Natl Acad Sci USA
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Czarnik, A.W.1
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36
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33751157590
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A general method for molecular tagging of encoded combinatorial chemistry libraries
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Nestler H.P., Bartlett P.A., Still W.C. A general method for molecular tagging of encoded combinatorial chemistry libraries. J Org Chem. 59:1994;4723-4724
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(1994)
J Org Chem
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Nestler, H.P.1
Bartlett, P.A.2
Still, W.C.3
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37
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33748243831
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Radiofrequency encoded combinatorial chemistry
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Nicolaou K.C., Xiao X.-Y., Parandoosh Z., Senyei A., Nova M.P. Radiofrequency encoded combinatorial chemistry. Angew Chem Int Ed Engl. 34:1995;2289-2291
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(1995)
Angew Chem Int Ed Engl
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Nicolaou, K.C.1
Xiao, X.-Y.2
Parandoosh, Z.3
Senyei, A.4
Nova, M.P.5
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38
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0034620738
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Toward larger chemical libraries: Encoding with fluorescent colloids in combinatorial chemistry
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Battersby B.J., Bryant D., Meutermans W., Matthews D., Smythe M.L., Trau M. Toward larger chemical libraries: encoding with fluorescent colloids in combinatorial chemistry. J Am Chem Soc. 122:2000;2138-2139
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(2000)
J Am Chem Soc
, vol.122
, pp. 2138-2139
-
-
Battersby, B.J.1
Bryant, D.2
Meutermans, W.3
Matthews, D.4
Smythe, M.L.5
Trau, M.6
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40
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0037028997
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Production, analysis, and application of spatially resolved shells in solid-phase polymer spheres
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Farrer R.A., Copeland G.T., Previte M.J.R., Okamoto M.M., Miller S.J., Fourkas J.T. Production, analysis, and application of spatially resolved shells in solid-phase polymer spheres. J Am Chem Soc. 124:2003;1994-2003
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(2003)
J Am Chem Soc
, vol.124
, pp. 1994-2003
-
-
Farrer, R.A.1
Copeland, G.T.2
Previte, M.J.R.3
Okamoto, M.M.4
Miller, S.J.5
Fourkas, J.T.6
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41
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0242635991
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Automated sorting of beads from a "one -bead-two-compounds" combinatorial library
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Christensen C., Groth T., Schiødt C.B., Foged N.T., Meldal M. Automated sorting of beads from a "one -bead-two-compounds" combinatorial library. Comb Sci. 7:2003;737-744
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(2003)
Comb Sci
, vol.7
, pp. 737-744
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-
Christensen, C.1
Groth, T.2
Schiødt, C.B.3
Foged, N.T.4
Meldal, M.5
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