COX-2 is necessary for venous ligation-mediated bone adaptation in mice

Bone

Volumn 38, Issue 1, 2006, Pages 93-104

  Stevens, H Y ^a   Meays, D R ^a   Yeh, J ^a   Bjursten, L M ^a   Frangos, J A ^a  

^a LA JOLLA BIOENGINEERING INSTITUTE   (United States)

Author keywords

Bone (re)modeling; Cyclooxygenase 2; Hindlimb suspension; Interstitial fluid flow; Knockout mice

Indexed keywords

CYCLOOXYGENASE 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MASS; BONE REMODELING; BONE TISSUE; CONTROLLED STUDY; CORTICAL BONE; EMBEDDING; FEMALE; FEMORAL VEIN; FEMUR; FLUID FLOW; HETEROZYGOTE; IMMOBILIZATION; INTERSTITIAL FLUID; KNOCKOUT MOUSE; LIMB; MALE; MECHANICAL STRESS; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOLYSIS; PERIOSTEUM; PROTEIN FUNCTION; SHEAR STRESS; STATISTICAL SIGNIFICANCE; VEIN LIGATION;

ANIMALS; BONE DENSITY; BONE REMODELING; CROSSES, GENETIC; CYCLOOXYGENASE 2; FEMALE; FEMORAL VEIN; HETEROZYGOTE; HINDLIMB; LIGATION; MALE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; TELEMETRY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 29344455096     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2005.07.006     Document Type: Article

References (54)

1. T. Miyamoto, N. Ogino, S. Yamamoto, and O. Hayaishi Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes J. Biol. Chem. 251 1976 2629 2636
2. G.D. Anderson, S.D. Hauser, K.L. McGarity, M.E. Bremer, P.C. Isakson, and S.A. Gregory Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis J. Clin. Invest. 97 1996 2672 2679
3. T.A. Samad, K.A. Moore, A. Sapirstein, S. Billet, A. Allchorne, and S. Poole Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity Nature 410 2001 471 475
4. M. Katori, and M. Majima Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors Inflamm. Res. 49 2000 367 392
5. J.E. Dinchuk, B.D. Car, R.J. Focht, J.J. Johnston, B.D. Jaffee, and M.B. Covington Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II Nature 378 1995 406 409
6. M.R. Forwood, W.L. Kelly, and N.F. Worth Localisation of prostaglandin endoperoxide H synthase (PGHS)-1 and PGHS-2 in bone following mechanical loading in vivo Anat. Rec. 252 1998 580 586
7. A. Ogasawara, T. Arakawa, T. Kaneda, T. Takuma, T. Sato, and H. Kaneko Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells J. Biol. Chem. 276 2001 7048 7054
8. Y. Okada, J.A. Lorenzo, A.M. Freeman, M. Tomita, S.G. Morham, and L.G. Raisz Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture J. Clin. Invest. 105 2000 823 832
9. X. Zhang, E.M. Schwarz, D.A. Young, J.E. Puzas, R.N. Rosier, and R.J. O'Keefe Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair J. Clin. Invest. 109 2002 1405 1415
10. T. Akamine, W.S. Jee, H.Z. Ke, X.J. Li, and B.Y. Lin Prostaglandin E2 prevents bone loss and adds extra bone to immobilized distal femoral metaphysis in female rats Bone 13 1992 11 22
11. A.M. Simon, M.B. Manigrasso, and J.P. O'Connor Cyclo-oxygenase 2 function is essential for bone fracture healing J. Bone Miner. Res. 17 2002 963 976
12. K.M. Reich, and J.A. Frangos Effect of flow on prostaglandin E2 and inositol trisphosphate levels in osteoblasts Am. J. Physiol. 261 1991 C428 C432
13. K.M. Reich, C.V. Gay, and J.A. Frangos Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production J. Cell. Physiol. 143 1990 100 104
14. K.M. Reich, and J.A. Frangos Protein kinase C mediates flow-induced prostaglandin E2 production in osteoblasts Calcif. Tissue Int. 52 1993 62 66
15. J. Klein-Nulend, E.H. Burger, C.M. Semeins, L.G. Raisz, and C.C. Pilbeam Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells J. Bone Miner. Res. 12 1997 45 51
16. M. Joldersma, E.H. Burger, C.M. Semeins, and J. Klein-Nulend Mechanical stress induces COX-2 mRNA expression in bone cells from elderly women J. Biomech. 33 2000 53 61
17. N.X. Chen, D.J. Geist, D.C. Genetos, F.M. Pavalko, and R.L. Duncan Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release Bone 33 2003 399 410
18. R.D. Roer, and R.M. Dillaman Bone growth and calcium balance during simulated weightlessness in the rat J. Appl. Physiol. 68 1990 13 20
19. T. Matsumoto, K. Nakayama, Y. Kodama, H. Fuse, T. Nakamura, and S. Fukumoto Effect of mechanical unloading and reloading on periosteal bone formation and gene expression in tail-suspended rapidly growing rats Bone 22 1998 89S 93S
20. M. Hughes-Fulford Changes in gene expression and signal transduction in microgravity J. Gravit. Physiol. 8 2001 1 4
21. Q. Chen, J.Y. Rho, Z. Fan, S.J. Laulederkind, and R. Raghow Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice Calcif. Tissue Int. 73 2003 387 392
22. I. Alam, S.J. Warden, A.G. Robling, and C.H. Turner Knockout of cyclooxygenase-2 (COX-2) in mice results in a skeletal phenotype but does not influence mechanical responsiveness JBMR 18 2003 S45
23. M. Xu, S. Choudhary, D. Goltzman, F. Ledgard, D. Adams, and G. Gronowicz Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? Endocrinology 146 2005 1843 1853
24. A.P. Bergula, M.A. Haidekker, W. Huang, H.Y. Stevens, and J.A. Frangos Venous ligation-mediated bone adaptation is NOS 3 dependent Bone 34 2004 562 569
25. E.R. Morey-Holton, and R.K. Globus Hindlimb unloading rodent model: technical aspects J. Appl. Physiol. 92 2002 1367 1377
26. H.Z. Ke, W.S. Jee, Q.Q. Zeng, M. Li, and B.Y. Lin Prostaglandin E2 increased rat cortical bone mass when administered immediately following ovariectomy Bone Miner. 21 1993 189 201
27. E. Seeman The structural and biomechanical basis of the gain and loss of bone strength in women and men Endocrinol. Metab. Clin. North Am. 32 2003 25 38
28. J. Ferretti, R. Mazure, P. Tanoue, A. Marino, G. Cointry, and H. Vazquez Analysis of the structure and strength of bones in celiac disease patients Am. J. Gastroenterol. 98 2003 382 390
29. M.L. Knothe Tate, R. Steck, M.R. Forwood, and P. Niederer In vivo demonstration of load-induced fluid flow in the rat tibia and its potential implications for processes associated with functional adaptation J. Exp. Biol. 203 Pt 18 2000 2737 2745
30. M.W. Otter, V.R. Palmieri, and G.V. Cochran Transcortical streaming potentials are generated by circulatory pressure gradients in living canine tibia J. Orthop. Res. 8 1990 119 126
31. A.P. Bergula, W. Huang, and J.A. Frangos Femoral vein ligation increases bone mass in the hindlimb suspended rat Bone 24 1999 171 177
32. I. Owan, D.B. Burr, C.H. Turner, J. Qiu, Y. Tu, and J.E. Onyia Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain Am. J. Physiol. 273 1997 C810 C815
33. R. Smalt, F.T. Mitchell, R.L. Howard, and T.J. Chambers Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain Am. J. Physiol. 273 1997 E751 E758
34. A.D. Lilly, and P.J. Kelly Effects of venous ligation on bone remodeling in the canine tibia J. Bone Joint Surg. Am. 52 1970 515 520
35. J.F. de Valderrama, and J. Trueta The effect of muscle action on the intra-osseous circulation J. Pathol. Bacteriol. 89 1965 179 186
36. R.M. Dillaman, R.D. Roer, and D.M. Gay Fluid movement in bone: theoretical and empirical J. Biomech. 24 Suppl 1 1991 163 177
37. P.J. Kelly Pathways of transport in bone 1983 Williams and Wilkins
38. P.J. Kelly, and J.T. Bronk Venous pressure and bone formation Microvasc. Res. 39 1990 364 375
39. T.M. Wang, J.F. Hsu, W.S. Jee, and J.L. Matthews Evidence for reduced cancellous bone mass in the spontaneously hypertensive rat Bone Miner. 20 1993 251 264
40. R.A. Chole, and D.E. Chan Rapid induction of localized bone resorption in the auditory bulla of the Mongolian gerbil, Meriones unguiculatus, by increased air pressure Calcif. Tissue Int. 45 1989 318 323
41. Y.X. Qin, T. Kaplan, A. Saldanha, and C. Rubin Fluid pressure gradients, arising from oscillations in intramedullary pressure, is correlated with the formation of bone and inhibition of intracortical porosity J. Biomech. 36 2003 1427 1437
42. Y.X. Qin, K. McLeod, and C. Rubin Intracortical fluid flow is induced by dynamic intramedullary pressure independent of matrix deformation Trans. Orthop. Res. Soc. 25 2000 0740
43. P.O. Iversen, E. Berggreen, G. Nicolaysen, and K. Heyeraas Regulation of extracellular volume and interstitial fluid pressure in rat bone marrow Am. J. Physiol. Heart Circ. Physiol. 280 2001 H1807 H1813
44. A.D. Bakker, K. Soejima, J. Klein-Nulend, and E.H. Burger The production of nitric oxide and prostaglandin E(2) by primary bone cells is shear stress dependent J. Biomech. 34 2001 671 677
45. T.N. McAllister, and J.A. Frangos Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways J. Bone Miner. Res. 14 1999 930 936
46. I. Westbroek, N.E. Ajubi, M.J. Alblas, C.M. Semeins, J. Klein-Nulend, and E.H. Burger Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow Biochem. Biophys. Res. Commun. 268 2000 414 419
47. A.D. Bakker, J. Klein-Nulend, and E.H. Burger Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1 Biochem. Biophys. Res. Commun. 305 2003 677 683
48. K.D. Ryder, and R.L. Duncan Parathyroid hormone modulates the response of osteoblast-like cells to mechanical stimulation Calcif. Tissue Int. 67 2000 241 246
49. N.X. Chen, K.D. Ryder, F.M. Pavalko, C.H. Turner, D.B. Burr, and J. Qiu Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts Am. J. Physiol. Cell Physiol. 278 2000 C989 C997
50. S. Wadhwa, S. Choudhary, M. Voznesensky, M. Epstein, L. Raisz, and C. Pilbeam Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway Biochem. Biophys. Res. Commun. 297 2002 46 51
51. S. Wadhwa, S.L. Godwin, D.R. Peterson, M.A. Epstein, L.G. Raisz, and C.C. Pilbeam Fluid flow induction of cyclo-oxygenase 2 gene expression in osteoblasts is dependent on an extracellular signal-regulated kinase signaling pathway J. Bone Miner. Res. 17 2002 266 274
52. B. Cheng, Y. Kato, S. Zhao, J. Luo, E. Sprague, and L.F. Bonewald PGE(2) is essential for gap junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanical strain Endocrinology 142 2001 3464 3473
53. M.V. Hillsley, and J.A. Frangos Bone tissue engineering: the role of interstitial fluid flow Biotechnol. Bioeng. 43 1994 573 581
54. J. Li, D.B. Burr, and C.H. Turner Suppression of prostaglandin synthesis with NS-398 has different effects on endocortical and periosteal bone formation induced by mechanical loading Calcif. Tissue Int. 70 2002 320 329