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Volumn 24, Issue 10-12, 2005, Pages 1801-1815

Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells

Author keywords

G Quadruplex interactive agent; Telomere; Telomestatin; TMPyP4

Indexed keywords

ANTINEOPLASTIC AGENT; GUANINE DERIVATIVE; TELOMESTATIN;

EID: 29244487119     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500267238     Document Type: Article
Times cited : (29)

References (44)
  • 1
    • 0029395466 scopus 로고
    • Aging and cancer: Are telomeres and telomerase the connection?
    • Shay, J.W. Aging and cancer: Are telomeres and telomerase the connection? Mol. Med. Today 1995, 1, 378.
    • (1995) Mol. Med. Today , vol.1 , pp. 378
    • Shay, J.W.1
  • 2
    • 0029895383 scopus 로고    scopus 로고
    • Refining the telomere-telomerase hypothesis of aging and cancer
    • Holt, S.E.; Shay, J.W.; Wright, W.E. Refining the telomere-telomerase hypothesis of aging and cancer. Nat. Biotechnol. 1996, 14, 836.
    • (1996) Nat. Biotechnol. , vol.14 , pp. 836
    • Holt, S.E.1    Shay, J.W.2    Wright, W.E.3
  • 3
    • 13844257292 scopus 로고    scopus 로고
    • Cellular lifespan and senescence signaling in embryonic stem cells
    • Miura, T.; Mattson, M.P.; Rao, M.S. Cellular lifespan and senescence signaling in embryonic stem cells. Aging Cell 2004, 3, 333.
    • (2004) Aging Cell , vol.3 , pp. 333
    • Miura, T.1    Mattson, M.P.2    Rao, M.S.3
  • 4
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright, W.E.; Shay, J.W. Historical claims and current interpretations of replicative aging. Nat. Biotechnol. 2002, 20, 682.
    • (2002) Nat. Biotechnol. , vol.20 , pp. 682
    • Wright, W.E.1    Shay, J.W.2
  • 7
    • 0031816339 scopus 로고    scopus 로고
    • Telomerase in cancer: Diagnostic, prognostic, and therapeutic implications
    • Shay, J.W. Telomerase in cancer: diagnostic, prognostic, and therapeutic implications. Cancer J. Sci. Am. 1998, 4, S26.
    • (1998) Cancer J. Sci. Am. , vol.4
    • Shay, J.W.1
  • 8
    • 0033004686 scopus 로고    scopus 로고
    • Role of telomerase in cellular proliferation and cancer
    • Holt, S.E.; Shay, J.W. Role of telomerase in cellular proliferation and cancer. J. Cell. Physiol. 1999, 180, 10.
    • (1999) J. Cell. Physiol. , vol.180 , pp. 10
    • Holt, S.E.1    Shay, J.W.2
  • 9
    • 0036782884 scopus 로고    scopus 로고
    • Telomerase: A target for cancer therapeutics
    • Shay, J.W.; Wright, W.E. Telomerase: a target for cancer therapeutics. Cancer Cell 2002, 2, 257.
    • (2002) Cancer Cell , vol.2 , pp. 257
    • Shay, J.W.1    Wright, W.E.2
  • 11
    • 0037889841 scopus 로고    scopus 로고
    • Telomere inhibition and telomere disruption as processes for drug targeting
    • Rezler, E.M.; Bearss, D.J.; Hurley, L.H. Telomere inhibition and telomere disruption as processes for drug targeting. Annu. Rev. Pharmacol. Toxicol. 2003, 43, 359.
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 359
    • Rezler, E.M.1    Bearss, D.J.2    Hurley, L.H.3
  • 13
    • 0031727943 scopus 로고    scopus 로고
    • G-quadruplex DNA: A target for drug design
    • Mergny, J.L.; Hélène, C. G-quadruplex DNA: a target for drug design. Nat. Med. 1998, 4, 1366.
    • (1998) Nat. Med. , vol.4 , pp. 1366
    • Mergny, J.L.1    Hélène, C.2
  • 15
    • 3242666778 scopus 로고    scopus 로고
    • Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    • Phan, A.T.; Modi, Y.S.; Patel, D.J. Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J. Am. Chem. Soc. 2004, 126, 8710.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 8710
    • Phan, A.T.1    Modi, Y.S.2    Patel, D.J.3
  • 16
    • 0037142071 scopus 로고    scopus 로고
    • Crystal structure of parallel quadruplexes from human telomeric DNA
    • Parkinson, G.N.; Lee, M.P.; Neidle, S. Crystal structure of parallel quadruplexes from human telomeric DNA. Nature 2002, 417, 876.
    • (2002) Nature , vol.417 , pp. 876
    • Parkinson, G.N.1    Lee, M.P.2    Neidle, S.3
  • 17
    • 4444304085 scopus 로고    scopus 로고
    • G-quadruplex interacting agents targeting the telomeric G-overhang are more than simple telomerase inhibitors
    • Riou, J.F. G-quadruplex interacting agents targeting the telomeric G-overhang are more than simple telomerase inhibitors. Curr. Med. Chem. Anti-Canc. Agents 2004, 4, 439.
    • (2004) Curr. Med. Chem. Anti-Canc. Agents , vol.4 , pp. 439
    • Riou, J.F.1
  • 19
    • 0035924232 scopus 로고    scopus 로고
    • Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase
    • Shi, D.-F.; Wheelhouse, R.T.; Sun, D.; Hurley, L.H. Quadruplex- interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J. Med. Chem. 2001, 44, 4509.
    • (2001) J. Med. Chem. , vol.44 , pp. 4509
    • Shi, D.-F.1    Wheelhouse, R.T.2    Sun, D.3    Hurley, L.H.4
  • 21
    • 6944239985 scopus 로고    scopus 로고
    • Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8, 13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
    • Leonetti, C.; Amodei, S.; D'Angelo, C.; Rizzo, A.; Benassi, B.; Antonelli, A.; Elli, R.; Stevens, M.F.; D'Incalci, M.; Zupi, G.; Biroccio, A. Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13- trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration. Mol. Pharmacol. 2004, 66, 1138.
    • (2004) Mol. Pharmacol. , vol.66 , pp. 1138
    • Leonetti, C.1    Amodei, S.2    D'Angelo, C.3    Rizzo, A.4    Benassi, B.5    Antonelli, A.6    Elli, R.7    Stevens, M.F.8    D'Incalci, M.9    Zupi, G.10    Biroccio, A.11
  • 22
    • 1642457358 scopus 로고    scopus 로고
    • A G-quadruplex ligand 3,3′-diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells
    • Li, C.P.; Huang, J.H.; Chang, A.C.; Hung, Y.M.; Lin, C.H.; Chao, Y.; Lee, S.D.; Whang-Peng, J.; Huang, T.S. A G-quadruplex ligand 3,3′- diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells. Pharm. Res. 2004, 21, 93.
    • (2004) Pharm. Res. , vol.21 , pp. 93
    • Li, C.P.1    Huang, J.H.2    Chang, A.C.3    Hung, Y.M.4    Lin, C.H.5    Chao, Y.6    Lee, S.D.7    Whang-Peng, J.8    Huang, T.S.9
  • 23
    • 1242342930 scopus 로고    scopus 로고
    • Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing
    • Gomez, D.; Lemarteleur, T.; Lacroix, L.; Mailliet, P.; Mergny, J.L.; Riou, J.F. Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing. Nucleic Acids Res. 2004, 32, 371.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 371
    • Gomez, D.1    Lemarteleur, T.2    Lacroix, L.3    Mailliet, P.4    Mergny, J.L.5    Riou, J.F.6
  • 27
    • 0037731436 scopus 로고    scopus 로고
    • The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures
    • Kim, M.-Y.; Gleason-Guzman, M.; Izbicka, E.; Nishioka, D.; Hurley, L.H. The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Res. 2003, 63, 3247.
    • (2003) Cancer Res. , vol.63 , pp. 3247
    • Kim, M.-Y.1    Gleason-Guzman, M.2    Izbicka, E.3    Nishioka, D.4    Hurley, L.H.5
  • 30
    • 0033594341 scopus 로고    scopus 로고
    • Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition
    • Han, F.X.; Wheelhouse, R.T.; Hurley, L.H. Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition. J. Am. Chem. Soc. 1999, 121, 3561.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 3561
    • Han, F.X.1    Wheelhouse, R.T.2    Hurley, L.H.3
  • 31
    • 0037015078 scopus 로고    scopus 로고
    • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    • U.S.A.
    • Siddiqui-Jain, A.; Grand, C.L.; Bearss, D.J.; Hurley, L.H. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 11593.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 11593
    • Siddiqui-Jain, A.1    Grand, C.L.2    Bearss, D.J.3    Hurley, L.H.4
  • 32
    • 0027052937 scopus 로고
    • Mapping the mammalian intercellular bridge
    • Rattner, J.B. Mapping the mammalian intercellular bridge. Cell Motil. Cytoskeleton 1992, 23, 231.
    • (1992) Cell Motil. Cytoskeleton , vol.23 , pp. 231
    • Rattner, J.B.1
  • 33
    • 0036606633 scopus 로고    scopus 로고
    • Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: Implications for the antiproliferative effects of antiestrogens
    • Carroll, J.S.; Swarbrick, A.; Musgrove, E.A.; Sutherland, R.L. Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: Implications for the antiproliferative effects of antiestrogens. Cancer Res. 2002, 62, 3126.
    • (2002) Cancer Res. , vol.62 , pp. 3126
    • Carroll, J.S.1    Swarbrick, A.2    Musgrove, E.A.3    Sutherland, R.L.4
  • 34
    • 0036597090 scopus 로고    scopus 로고
    • The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse trariscriptase expression and inhibits tumor growth in vivo
    • Grand, C.L.; Han, H.; Muñoz, R.M.; Weitman, S.; Von Hoff, D.D.; Hurley, L.H.; Bearss, D.J. The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse trariscriptase expression and inhibits tumor growth in vivo. Mol. Cancer Ther. 2002, 1, 565.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 565
    • Grand, C.L.1    Han, H.2    Muñoz, R.M.3    Weitman, S.4    Von Hoff, D.D.5    Hurley, L.H.6    Bearss, D.J.7
  • 36
    • 0037070575 scopus 로고    scopus 로고
    • Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex
    • Kim, M.-Y.; Vankayalapati, H.; Shin-ya, K.; Wierzba, K.; Hurley, L.H. Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex. J. Am. Chem. Soc. 2002, 124, 2098.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 2098
    • Kim, M.-Y.1    Vankayalapati, H.2    Shin-ya, K.3    Wierzba, K.4    Hurley, L.H.5
  • 37
    • 0035206465 scopus 로고    scopus 로고
    • Secondary DNA structures as molecular targets for cancer therapeutics
    • Hurley, L.H. Secondary DNA structures as molecular targets for cancer therapeutics. Biochem. Soc. Trans. 2001, 29, 692.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 692
    • Hurley, L.H.1
  • 38
    • 0033455559 scopus 로고    scopus 로고
    • Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
    • U.S.A.
    • Herbert, B.; Pitts, A.E.; Baker, S.I.; Hamilton, S.E.; Wright, W.E.; Shay, J.W.; Corey, D.R. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 14276.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 14276
    • Herbert, B.1    Pitts, A.E.2    Baker, S.I.3    Hamilton, S.E.4    Wright, W.E.5    Shay, J.W.6    Corey, D.R.7
  • 39
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang, X.; Mar, V.; Zhou, W.; Harrington, L.; Robinson, M.O. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 1999, 13, 2388.
    • (1999) Genes Dev. , vol.13 , pp. 2388
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 40
  • 41
    • 0038025489 scopus 로고    scopus 로고
    • Telomere repeat binding factors: Keeping the ends in check
    • Karlseder, J. Telomere repeat binding factors: keeping the ends in check. Cancer Lett. 2003, 194, 189.
    • (2003) Cancer Lett. , vol.194 , pp. 189
    • Karlseder, J.1
  • 42
    • 12844265975 scopus 로고    scopus 로고
    • Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
    • Lei, M.; Podell, E.R.; Cech, T.R. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat. Struct. Mol. Biol. 2004, 11, 1223.
    • (2004) Nat. Struct. Mol. Biol. , vol.11 , pp. 1223
    • Lei, M.1    Podell, E.R.2    Cech, T.R.3
  • 43
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel, B.; Smogorzewska, A.; de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998, 92, 401.
    • (1998) Cell , vol.92 , pp. 401
    • Van Steensel, B.1    Smogorzewska, A.2    De Lange, T.3
  • 44
    • 11144277882 scopus 로고    scopus 로고
    • Loss of hPot1 function leads to telomere instability and a cut-like phenotype
    • Veldman, T.; Etheridge, K.T.; Counter, C.M. Loss of hPot1 function leads to telomere instability and a cut-like phenotype. Curr. Biol. 2004, 14, 2264.
    • (2004) Curr. Biol. , vol.14 , pp. 2264
    • Veldman, T.1    Etheridge, K.T.2    Counter, C.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.