Nr-CAM: A cell adhesion molecule with ligand and receptor functions

Cell and Tissue Research

Volumn 290, Issue 2, 1997, Pages 423-428

  Grumet, Martin ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Axonal guidance; Cell adhesion; Ig superfamily; Neural development; Neurite growth; Nr CAM

Indexed keywords

CELL ADHESION MOLECULE; LIGAND; RECEPTOR;

ARTICLE; CELL ADHESION; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; PRIORITY JOURNAL; SCHWANN CELL; SPINAL CORD;

ANIMALS; CELL ADHESION MOLECULES; CELL ADHESION MOLECULES, NEURONAL; HUMANS; LIGANDS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGY; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC;

EID: 0030728957     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050949     Document Type: Article

References (42)

1. Brummendorf T, Ruthjen FG (1995) Cell adhesion molecules. I. Immunoglobulin superfamily. Protein Profile 2:963-1108
2. Buchstaller A, Kunz S, Berger P, Ziegler U, Rader C, Sonderegger P (1996) Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion. J Cell Biol 135:1593-1607
3. Burgoon MP, Grumet M, Mauro V, Edelman GM, Cunningham BA (1991) Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of polypeptides and relation to Ig superfamily. J Cell Biol 112:1017-102.
4. Davis JQ, Bennett V (1994) Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. J Biol Chem 269:27163-27165
5. Davis JQ, Lambert S, Bennett V (1996) Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FnIII domain-) and Nr-CAM at nodal axon segments. J Cell Biol 135: 1355-1367
6. Denburg JL, Caldwell RT, Marner JM (1995) Developmental changes in epitope accessibility as an indicator of multiple states of an immunoglobulin-like neural cell adhesion molecule. J Comp Neurol 354:533-550
7. Dodd J, Jessell TM (1988) Axon guidance and the patterning of neuronal connection in vertebrates. Science 242:692-699
8. Doherty P, Walsh FS (1994) Signal transduction events underlying neurite outgrowth stimulated by cell adhesion molecules. Curr Opin Neurobiol 4:49-55
9. Dubreuil RR, MacVicar G, Dissanayake S, Liu C, Homer D, Hortsch M (1996) Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites. J Cell Biol 133:647-655
10. Garver TD, Ren Q, Tuvia S, Bennett V (1997) Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin-binding and increases lateral mobility of neurofascin. J Cell Biol 137:703-714
11. Green PJ, Walsh FS, Doherty P (1996) Promiscuity of fibroblast growth factor receptors. Bioessays 18:639-646
12. Grumet M (1991) Cell adhesion molecules and their subgroups in the nervous system. Curr Opin Neurobiol 1:370-376
13. Grumet M (1992) Structure, expression, and function of Ng-CAM, a member of the immunoglobulin superfamily involved in neuron-neuron and neuron-glia adhesion. J Neurosci Res 31:1-13
14. Grumet M, Sakurai T (1996) Interactions of the cell adhesion molecules Ng-CAM and Nr-CAM with neural receptors and extracellular matrix proteins. Semin Neurosci 8:379-389
15. Grumet M, Mauro V, Burgoon MP, Edelman GM, Cunningham BA (1991) Structure and characterization of Nr-CAM, a new member of the Ig superfamily that is closely related to Ng-CAM. J Cell Biol 113:1399-1412
16. Hoffman S, Edelman GM (1983) Kinetics of homophilic binding by E and A forms of the neural cell adhesion molecule. Proc Natl Acad Sci USA 80:5762-5766
17. Hosaka M, Nagahama M, Kim WS, Watanabe T, Hatsuzawa K, Ikemizu J, Murakami K, Nakayama K (1991) Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem 266: 12127-12130
18. Jiang Y-P, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J, Sap J (1993) Cloning and characterization of R-PTP-κ, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region. Mol Cell Biol 13:2942-2951
19. Kayyem JF, Roman JM, Rosa EJ de la, Schwarz U, Dreyer WJ (1992) Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structure. J Cell Biol 118:1259-1270
20. Krushel LA, Prieto AL, Cunningham BA, Edelman GM (1993) Expression patterns of the cell adhesion molecules Nr-CAM during histogenesis of the chick nervous system. Neuroscience 53:797-812
21. Lane RP, Chen X-N, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ (1996) Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. Genomics 35:456-465
22. Lemmon V, Burden SM, Payne HR, Elmslie GJ, Hlavin ML (1992) Neurite growth on different substrates: permissive versus instructive influence and the role of adhesive strength. J Neurosci 12:818-826
23. Mauro V, Krushel L, Cunningham B, Edelman GM (1992) Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion molecule. J Cell Biol 119:191-202
24. Milev P, Maurel P, Haring M, Margolis RK, Margolis RU (1996) TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-ζ/β, and N-CAM. J Biol Chem 271:15716-15723
25. Morales G, Hubert M, Brummendorf T, Treubert U, Tarnok A, Schwarz U, Rathjen FG (1993) Induction of axonal growth by heterophilic interactions between the cell surface recognition proteins F11 and Nr-CAM/Bravo. Neuron 11:1113-1122
26. Moscoso LM, Sanes JR (1995) Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol 352:321-334
27. Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J (1995) The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin. Cell 82:251-260
28. Reichardt LF, Bixby JL, Hall DE, Ignatius MJ, Neugebauer KM, Tomaselli KJ (1991) Integrins and cell adhesion molecules: neuronal receptors that regulate axon growth on extracellular matrices and cell surfaces. Dev Neurosci 11:332-347
29. Rosa EJ de la, Kayyem JF, Roman JM, Stierhof Y-D, Dreyer WJ, Schwarz U (1990) Topologically restricted appearance in the developing chick retinotectal system of Bravo, a neural surface protein: experimental modulation by environmental cues. J Cell Biol 111:3087-3096
30. Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (1997) Induction of neurite outgrowth through neuronal cell adhesion molecules contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase β. J Cell Biol 136:907-918
31. Sheng M (1996) PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron 17:575-578
32. Shiga T, Oppenheim RW (1991) Immunolocalization studies of putative guidance molecules used by axons and growth cones of intersegmental interneurons in the chick embryo spinal cord. J Cornp Neurol 310:234-252
33. Shiga T, Oppenheim RW, Grumet M, Edelman GM (1990) Neuron-glia cell adhesion molecule (Ng-CAM) expression in the chick spinal cord: observations on the earliest developing intersegmental interneurons. Dev Brain Res 55:209-217
34. Stoeckli ET, Landmesser LT (1995) Axonin-1, Nr-CAM and Ng-CAM play different roles in the in vivo guidance of chick commissural neurons. Neuron 14:1165-1179
35. Stoeckli ET, Ziegler U, Bleiker AJ, Groscurth P, Sonderegger P (1996) Clustering and functional cooperation of Ng-CAM and axonin-1 in the substratum-contact area of growth cones. Dev Biol 177:15-29
36. Stoeckli ET, Sonderegger P, Pollerberg GE, Landmesser L (1997) Interference with axonin-1 and Nr-CAM interactions unmasks a floorplate activity inhibitory for commissural axons. Neuron 18:209-221
37. Suter DM, Pollerberg GE, Buchstaller A, Giger RJ, Dreyer WJ, Sonderegger P (1995) Binding between the neural cell adhesion molecules axonin-1 and Nr-CAM/Bravo is involved in neuron-glia interaction. J Cell Biol 131:1067-1081
38. Takeichi M (1991) Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251:1451-1455
39. Volkmer H, Hassel B, Wolff JM, Frank R, Rathjen FG (1992) Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily. J Cell Biol 118:149-161
40. Volkmer H, Leuschner R, Zacharias U, Rathjen FG (1996) Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. J Cell Biol 135:1059-1069
41. Wong EV, Kenwrick S, Willems P, Lemmon V (1995) Mutations in the cell adhesion molecule L1 cause mental retardation. Trends Neurosci 18:168-172
42. Wong EV, Schaefer AW, Landreth G, Lemmon V (1996) Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J Biol Chem 271:18217-18223