Interfacial adsorption of insulin: Conformational changes and reversibility of adsorption

European Journal of Pharmaceutical Sciences

Volumn 27, Issue 2-3, 2006, Pages 194-204

  Mollmann, Susanne H ^a,b   Jorgensen, Lene ^a   Bukrinsky, Jens T ^b   Elofsson, Ulla ^c   Norde, Willem ^d,e   Frokjaer, Sven ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c INSTITUTE FOR SURFACE CHEMISTRY   (Sweden)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Conformational changes; Insulin; Protein adsorption; Protein structure; Teflon

Indexed keywords

BUFFER; INSULIN; MONOMER; PHOSPHATE; PROTEIN;

ADSORPTION KINETICS; ALPHA HELIX; ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DESORPTION; DRUG CONFORMATION; DRUG STRUCTURE; FLUORESCENCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; THERMOSTABILITY;

ADSORPTION; CIRCULAR DICHROISM; DRUG STABILITY; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; POLYTETRAFLUOROETHYLENE; PROTEIN CONFORMATION; PROTEIN FOLDING; RECOMBINANT PROTEINS; SOLUTIONS; SPECTROMETRY, FLUORESCENCE; TEMPERATURE;

EID: 29244452592     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.09.010     Document Type: Article

References (47)

1. T. Arnebrant, and T. Nylander Adsorption of insulin on metal surfaces in relation to association behavior J. Colloid Interface Sci. 122 1988 557 566
2. D.L. Bakaysa, J. Radziuk, H.A. Havel, M.L. Brader, S. Li, S.W. Dodd, J.M. Beals, A.H. Pekar, and D.N. Brems Physicochemical basis for the rapid time-action of lys(b28)pro(b29)-insulin-dissociation of a protein-ligand complex Protein Sci. 5 1996 2521 2531
3. J. Brange Stability of Insulin: Studies on the Physical and Chemical Stability of Insulin in Pharmaceutical Formulation 1994 Kluwer Academic Publishers Boston
4. J. Brange, L. Andersen, E.D. Laursen, G. Meyn, and E. Rasmussen Toward understanding insulin fibrillation J. Pharm. Sci. 86 1997 517 525
5. J. Brange, and L. Langkjaer Insulin structure and stability Pharm. Biotechnol. 5 1993 315 350
6. J. Brange, U. Ribel, J.F. Hansen, G. Dodson, M.T. Hansen, S. Havelund, S.G. Melberg, F. Norris, K. Norris, and L. Snel Monomeric insulins obtained by protein engineering and their medical implications Nature 333 1988 679 682
7. D.N. Brems, P.L. Brown, C. Bryant, R.E. Chance, L.K. Green, H.B. Long, A.A. Miller, R. Millican, J.E. Shields, and B.H. Frank Improved insulin stability through amino acid substitution Protein Eng. 5 1992 519 525
8. J. Bringer, A. Heldt, and G.M. Grodsky Prevention of insulin aggregation by dicarboxylic amino acids during prolonged infusion Diabetes 30 1981 83 85
9. A.S. Chawla, I. Hinberg, P. Blais, and D. Johnson Aggregation of insulin, containing surfactants, in contact with different materials Diabetes 34 1985 420 424
10. A. Gajraj, and R.Y. Ofoli Effect of extrinsic fluorescent labels on diffusion and adsorption kinetics of proteins at the liquid-liquid interface Langmuir 16 2000 8085 8094
11. C.E. Giacomelli, and W. Norde Influence of hydrophobic Teflon particles on the structure of amyloid beta-peptide Biomacromolecules 4 2003 1719 1726
12. N.G. Hentz, J.M. Richardson, J.R. Sportsman, J. Daijo, and G.S. Sittampalam Synthesis and characterization of insulin-fluorescein derivatives for bioanalytical applications Anal. Chem. 69 1997 4994 5000
13. V. Hlady, and J. Buijs Local and global optical spectroscopic probes of adsorbed proteins M. Malmsten Biopolymers at Interfaces second ed. 2003 Marcel Dekker New York 435 466
14. V. Hlady, A. Van Wagenen, and J.D. Andrade Total internal reflection intrinsic fluorescence (TIRIF) spectroscopy applied to protein adsorption J.D. Andrade Surface and Interfacial Aspects of Biomedical Polymers, vol. 2, Protein Adsorption 1985 Plenum Press New York 81 119
15. K. Huus, S. Havelund, H.B. Olsen, M. van de Weert, and S. Frokjaer Thermal dissociation and unfolding of insulin Biochemistry 44 2005 11171 11177
16. L. Jorgensen, M. van de Weert, C. Vermehren, S. Bjerregaard, and S. Frokjaer Probing structural changes of proteins incorporated into water-in-oil emulsions J. Pharm. Sci. 93 2004 1847 1859
17. S. Koutsopoulos, A.M. Tjeerdsma, J.F. Lieshout, O. van-der, and W. Norde In situ structure and activity studies of an enzyme adsorbed on spectroscopically undetectable particles Biomacromolecules 6 2005 1176 1184
18. Y.M. Kwon, M. Baudys, K. Knutson, and S.W. Kim In situ study of insulin aggregation induced by water-organic solvent interface Pharm. Res. 18 2001 1754 1759
19. 2 surfaces by means of ellipsometry, using different ambient media J. Phys. Chem. 97 1993 1656
20. V.J. Lenz, M. Federwisch, H. Gattner, D. Brandenburg, H. Hoecker, U. Hassiepen, and A. Wollmer Structure and rotational dynamics of fluorescently labeled insulin in aqueous solution and at the amphiphile-water interface of reversed micelles Biochemistry 34 1995 6130 6141
21. B.K. Lok, Y. Cheng, and C.R. Robertson Total internal reflection fluorescence: a technique for examining interaction of macromolecules with solid surfaces J. Colloid Interface Sci. 91 1983 87 103
22. W.D. Lougheed, A.M. Albisser, H.M. Martindale, J.C. Chow, and J.R. Clement Physical stability of insulin formulations Diabetes 32 1983 424 432
23. P. Manavalan, and W.C. Johnson Sensitivity of circular dichroism to protein tertiary structure glass Nature (London) 305 1983 831 832
24. R.L. Millican, and D.N. Brems Equilibrium intermediates in the denaturation of human insulin and two monomeric insulin analogs Biochemistry 33 1994 1116 1124
25. S.H. Mollmann, J.T. Bukrinsky, S. Frokjaer, and U. Elofsson Adsorption of human insulin and Asp(B28) insulin on a PTFE-like surface J. Colloid Interface Sci. 286 2005 28 35
26. Mollmann, S.H., Elofsson, U., Bukrinsky, J.T., Frokjaer, S., 2005b. Displacement of adsorbed insulin by Tween 80 using total internal reflection fluorescence. Pharm. Res., in press.
27. L. Nielsen, S. Frokjaer, J. Brange, V.N. Uversky, and A.L. Fink Probing the mechanism of insulin fibril formation with insulin mutants Biochemistry 40 2001 8397 8409
28. L. Nielsen, R. Khurana, A. Coats, S. Frokjaer, J. Brange, S. Vyas, V.N. Uversky, and A.L. Fink Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism Biochemistry 40 2001 6036 6046
29. P. Nilsson, T. Nylander, and S. Havelund Adsorption of insulin on solid surfaces in relation to the surface properties of the monomeric and oligomeric forms J. Colloid Interface Sci. 144 1991 145 152
30. W. Norde Proteins at solid surfaces A. Baszkin W. Norde Physical Chemistry of Biological Interfaces 2000 Marcel Dekker, Inc. New York 115 135
31. W. Norde, and C.E. Giacomelli BSA structural changes during homomolecular exchange between the adsorbed and the dissolved states J. Biotechnol. 79 2000 259 268
32. W. Norde, and J. Lyklema Why proteins prefer interfaces J. Biomater. Sci. Polym. Ed. 2 1991 183 202
33. W. Norde, and T. Zoungrana Surface-induced changes in the structure and activity of enzymes physically immobilized at solid/liquid interfaces Biotechnol. Appl. Biochem. 28 Pt 2 1998 133 143
34. C.N. Pace, F. Vajdos, L. Fee, G. Grimsley, and T. Gray How to measure and predict the molar absorption coefficient of a protein Protein Sci. 4 1995 2411 2423
35. C. Petty Insulin adsorption by glass infusion bottles, polyvinylchloride infusion containers, and intravenous tubing Anesthesiology 40 1974 400 404
36. Y. Pocker, and S.B. Biswas Conformational dynamics of insulin in solution. Circular dichroic studies Biochemistry 19 1980 5043 5049
37. K.C. Popat, R.W. Johnson, and T.A. Desai Characterization of vapor deposited thin silane films on silicon substrates for biomedical microdevices Surf. Coat. Technol. 154 2002 253 261
38. C.M. Roth, and A.M. Lenhoff Electrostatic and van-der-waals contributions to protein adsorption - comparison of theory and experiment Langmuir 11 1995 3500 3509
39. V. Sluzky, A.M. Klibanov, and R. Langer Mechanism of insulin aggregation and stabilization in agitated aqueous solutions Biotechnol. Bioeng. 40 1992 895 903
40. V. Sluzky, J.A. Tamada, A.M. Klibanov, and R. Langer Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces Proc. Natl. Acad. Sci. U.S.A. 88 1991 9377 9381
41. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, and D.C. Klenk Measurement of protein using bicinchoninic acid Anal. Biochem. 150 1985 76 85
42. H. Thurow, and K. Geisen Stabilization of dissolved proteins against denaturation at hydrophobic interfaces Diabetologia 27 1984 212 218
43. S.T. Tzannis, W.M. Hrushesky, P.A. Wood, and T.M. Przybycien Irreversible inactivation of interleukin 2 in a pump-based delivery environment Proc. Natl. Acad. Sci. U.S.A. 93 1996 5460 5465
44. T. Vermonden, C.E. Giacomelli, and W. Norde Reversibility of structural rearrangements in bovine serum albumin during homomolecular exchange from AgI particles Langmuir 17 2001 3734 3740
45. J.L. Whittingham, D.J. Scott, K. Chance, A. Wilson, J. Finch, J. Brange, and D. Guy Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation J. Mol. Biol. 318 2002 479 490
46. C.S. Wu, and G.C. Chen Adsorption of proteins onto glass surfaces and its effect on the intensity of circular dichroism spectra Anal. Biochem. 177 1989 178 182
47. Z. Xu, and R.E. Marchant Adsorption of plasma proteins on polyethylene oxide-modified lipid bilayers studied by total internal reflection fluorescence Biomaterials 21 2000 1075 1083