In situ study of insulin aggregation induced by water-organic solvent interface

Pharmaceutical Research

Volumn 18, Issue 12, 2001, Pages 1754-1759

  Kwon, Young Min ^a   Baudys, Miroslav ^a   Knutson, Kristine ^a   Kim, Sung Kim ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Insulin aggregation; Microsphere preparation; Protein stability; Turbidity measurement

Indexed keywords

BUFFER; DICHLOROMETHANE; DODECYL MALTOSIDE; DODECYL SULFATE SODIUM; INSULIN; MICROSPHERE; ORGANIC SOLVENT; PHOSPHATE; POLYGLACTIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; DRUG CONFORMATION; DRUG STABILITY; DRUG SYNTHESIS; EVALUATION; MICROENCAPSULATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SPECTROPHOTOMETRY; TEMPERATURE SENSITIVITY; TURBIDITY;

CHEMISTRY, PHYSICAL; CIRCULAR DICHROISM; DELAYED-ACTION PREPARATIONS; DRUG STABILITY; EXCIPIENTS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MICROSPHERES; PROTEIN CONFORMATION; SURFACE-ACTIVE AGENTS;

EID: 0035663205     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013334916162     Document Type: Article

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