Physicochemical basis for the rapid time-action of LysB28ProB29-insulin: Dissociation of a protein-ligand complex

Protein Science

Volumn 5, Issue 12, 1996, Pages 2521-2531

  Bakaysa, Diane L ^a   Radziuk, Jerry ^b   Havel, Henry A ^a   Brader, Mark L ^a   Li, Shun ^a   Dodd, Steven W ^a   Beals, John M ^a   Pekar, Allen H ^a   Brems, David N ^a,c  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c AMGEN INC   (United States)

Author keywords

Allosteric transition; In vivo activity; Ligand binding; Oligomer dissociation; Protein structure

Indexed keywords

ABSORPTION SPECTROSCOPY; AMINO ACID SUBSTITUTION; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIABETES CONTROL; DISSOCIATION; INSULIN METABOLISM; LIGAND BINDING; LIGHT SCATTERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE;

ALLOSTERIC REGULATION; FEMALE; HUMANS; INSULIN; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION;

SUS SCROFA;

EID: 0030479856     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560051215     Document Type: Article

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