Synthesis of a convenient thymidine glycol phosphoramidite monomer and its site-specific incorporation into DNA fragments

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 10-12, 2005, Pages 1831-1842

  Gasparutto, Didier ^a   Cognet, Sonia ^a   Roussel, Solveig ^a   Cadet, Jean ^a  

^a CEA GRENOBLE   (France)

Author keywords

Chemical synthesis; Oligodeoxyribonucleotide; Oxidative DNA lesion; Protecting groups; Thymine glycol

Indexed keywords

5,6 DIHYDRO 5,6 DIHYDROXYTHYMIDINE; DNA FRAGMENT; MONOMER; NUCLEIC ACID BASE; NUCLEOSIDE; PHOSPHORAMIDOUS ACID;

ARTICLE; DEPROTECTION REACTION; DIASTEREOISOMER; EPIMERIZATION; ISOMER; MASS SPECTROMETRY; OXIDATION; SOLID PHASE SYNTHESIS; SYNTHESIS;

DNA DAMAGE; OLIGODEOXYRIBONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; OXIDATION-REDUCTION; THYMIDINE;

EID: 29244439956     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500267279     Document Type: Article

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41. Modified 5-mer [sequence : TG(1)CA]: mass calculated = 1512.0 Da; mass found = 1511.7 Da. Modified 14-mer [sequence: ATCGTGAC(1)GATCT]: mass calculated = 4287.8 Da; mass found = 4286.9 Da. Modified 34-mer [sequence: GGCTTCATCGTTGTC(1)GAGACCTGGTGGATACCG]: mass calculated = 10.474.8 Da; mass found = 10475.4 Da.
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