Embryopathy in experimental diabetic gestation: Assessment of PGE 2 level, gene expression of cyclooxygenases and apoptosis

British Journal of Biomedical Science

Volumn 62, Issue 4, 2005, Pages 161-165

  El Bassiouni, E A ^a   Helmy, Madiha H ^b   Abou Rawash, N ^b   El Zoghby, S M ^b   Abd El Nabi Kamel, M ^b   Abou Raya, A N ^c  

^a Alexandria University Faculty of Pharmacy   (Egypt)

^b ALEXANDRIA UNIVERSITY   (Egypt)

^c ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Apoptosis; Cyclooxygenases; Diabetes mellitus; Fetal development; Prostaglandins; Teratogens

Indexed keywords

CASPASE 3; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMBRYO; EMBRYOPATHY; ENZYME ACTIVITY; FEMALE; FETUS DEVELOPMENT; GENE EXPRESSION; GESTATION PERIOD; NONHUMAN; ORGANOGENESIS; PATHOGENESIS; PLACENTA; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; RAT; RISK FACTOR; STREPTOZOCIN DIABETES; YOLK SAC;

ANIMALIA;

EID: 29144536704     PISSN: 09674845     EISSN: None     Source Type: Journal    
DOI: 10.1080/09674845.2005.11732704     Document Type: Article

References (27)

1. Reece EA, Homko CJ, Wu YK, Wiznitzer A. The role of free radicals and membrane lipids in diabetes-induced congenital malformations. J Soc Gynecol Invest 1998; 5: 178-87.
2. Piddington R, Joyce J, Dhanasekaran P, Baker L. Diabetes mellitus affects prostaglandin E2 levels in mouse embryos during neurulation. Diabetologia 1996; 39: 915-20.
3. Eriksson UJ, Borg LAH. Diabetes and embryonic malformations. Role of substrate-induced free oxygen radical production for dysmorphogenesis in cultured rat embryos. Diabetes 1993; 42: 411-9.
4. Goldman AS, Baker L, Piddington R, Marx B, Herold R, Elger J. Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Proc Natl Acad Sci USA 1985; 82: 8227-31.
5. Stanfield KM, Bell RR, Lisowski AR, English ML, Saldeen SS, Khan KN. Expression of cyclooxygenase-2 in embryonic and fetal tissues during organogenesis and late pregnancy. Birth Defects Res Part A Clin Mol Teratol 2003; 67: 54-8.
6. Moley KH. Hyperglycemia and apoptosis: mechanisms for congenital malformations and pregnancy loss in diabetic women. Trend Endocrinol Metab 2001; 12: 78-82.
7. Sun T, Kawasaki E, Akazawa S et al. Apoptosis and its pathway in early post-implantation embryos of diabetic rats. Diabetes Res Clin Pract 2005; 67: 110-8.
8. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to run: a comprehensive update of caspase substrates (Review). Cell Death Differ 2003; 10: 76-100.
9. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6.
10. El-Bassiouni EA, Helmy MH, Abou Rawash N, EL-Zoghby SM, Kamel MA-N, Abou Raya AN. Embryopathy in experimental diabetic gestation: assessment of oxidative stress and antioxidant defence. Br J Biomed Sci 2005, 62: 71-6.
11. Maclouf J, Grassi J, Pradelles P. Development of enzyme-immunoassay techniques for the measurement of eicosanoids. Prostaglandin Lipid Metabol Radiation Injury 1987; 355-64.
12. Lee HS, Soyoola E, Chanmugam P et al. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 1992; 267: 25934-8.
13. Thronberry NA. Interleukin-1 beta converting enzyme. Methods Enzymol 1994; 244: 615-21.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
15. 2, levels in rat embryos exposed to a diabetic environment. Diabetes 1999; 48: 813-20.
16. Kumagai T, Kawamoto Y, Nakamura Y et al. 4-hydroxy-2-nonenal, the end product of lipid peroxidation, is a specific inducer of cyclooxygenase-2 gene expression. Biochem Biophys Res Commun 2000; 273: 437-41.
17. 2 transport in embryos from overtly diabetic rats. Reprod Fertil Dev 2000; 12: 141-7.
18. Subbaramaiah K, Altorki N, Chung WJ, Mestre JR, Sampa A, Dannenberg AJ. Inhibition of cyclooxygenase-2 gene expression by p53. J Biol Chem 1999; 274: 10911-5.
19. Fiordaliso F, Leri A, Cesselli D et al. Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death. Diabetes 2001; 50: 2363-75.
20. Cao YZ, Reddy CC, Sordillo LM. Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. Free Radic Biol Med 2000; 28: 381-9.
21. Form DM, Auerbach R. PGE2 and angiogenesis. Proc Soc Exp Biol Med 1983; 172: 214-8.
22. Marsh J. Angiogenesis: trailblazer of the body or harmful cancer-causing agent? Harvard Science Review 2002; 1: 27-9.
23. Reece EA, Pinter E, Leranth CZ. Yolk sac failure in embryopathy due to hyperglycemia: horseradish peroxidase uptake in the assessment of yolk sac function. Obstet Gynecol 1989; 74: 755-62.
24. Reece EA, Pinter E, Homko C, Wu Y-K, Naftolin F. The yolk sac theory: closing the circle on why diabetes-associated malformations occur. J Soc Gynecol Invest 1994; 1: 3-13.
25. Reece EA. Maternal fuels, diabetic embryopathy: pathomechanisms and prevention. Semin Reprod Med 1999; 17: 183-94.
26. Wang T, Gotoh Y, Jennings MH, Rhoads CA, Aw TY. Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cell is associated with an early loss of cellular redox balance. FASEB J 2000; 14: 1567-76.
27. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptor. Cell 1995; 83: 841-50.