Diminished PGE2 content, enhanced PGE2 release and defects in 3H-PGE2 transport in embryos from overtly diabetic rats

Reproduction, Fertility and Development

Volumn 12, Issue 3-4, 2000, Pages 141-147

  Jawerbaum, A ^a   Gonzalez, E T ^a   Sinner, D ^a   Pustovrh, C ^a   White, V ^a   Gimeno, M A F ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Diabetic embryopathy; Malformations; Pregnancy diabetes; Prostaglandin E2; Rat embryo culture

Indexed keywords

PROSTAGLANDIN E2; STREPTOZOCIN; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYOPATHY; HORMONE TRANSPORT; INCUBATION TIME; MATING; NONHUMAN; ORGANOGENESIS; PROSTAGLANDIN RELEASE; RAT; STREPTOZOCIN DIABETES; ACTIVE TRANSPORT; ANIMAL; CONGENITAL MALFORMATION; CULTURE MEDIUM; EXPERIMENTAL DIABETES MELLITUS; FEMALE; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRENATAL DEVELOPMENT; SECRETION; WISTAR RAT;

ANIMALIA; TRITIUM;

ABNORMALITIES; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CULTURE MEDIA; DIABETES MELLITUS, EXPERIMENTAL; DINOPROSTONE; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; PREGNANCY; PREGNANCY IN DIABETICS; RATS; RATS, WISTAR; TRITIUM;

EID: 0034351537     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/rd00036     Document Type: Article

References (36)

1. Myoinositol and prostaglandins reverse the glucose inhibition of neural tube fusion in cultured mouse embryos
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. 2 transport across the plasma membrane of HeLa cells and xenopus oocytes expressing the prostaglandin transporter 'PGT'
4. Mouse embryo fibroblasts in culture: Characteristics of arachidonic acid metabolism during early passages. Prostaglandins Leukotrienes Essent
5. Effects of maternal diabetes or in vitro hyperglycemia on uptake or palmitic and arachidonic acid by rat embryos
6. Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro
7. Pregnant rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring
8. Diabetic embryopathy: Studies with animal and in vitro models
9. 2α in uterine strips isolated from ovariectomized rats: Influence of in vitro progesterone
10. Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid
11. 2 prevents anomalies induced by hyperglycemia or diabetic serum in mouse embryos
12. Mouse spermatozoa can synthesize PGE and 5HETE in vitro: Stimulatory action of nitric oxide. Prostaglandins Leukotrienes Essent
13. 2 in isolated rat uteri
14. Nitric oxide mediates hCG induced prostaglandin E generation in rat oocyte-cumulus complexes
15. Increased prostaglandin E generation and enhanced nitric oxide synthase activity in the non-insulin-dependent diabetic embryo during organogenesis
16. 3H prostaglandins in vitro
17. Identification and characterization of a prostaglandin transporter
18. Diabetic pregnancy and perinatal morbidity
19. Measurements of prostaglandins in embryonic tissue using radioimmunoassay
20. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH
21. 2alpha in the neoplastic cells as revealed by autoradiographic studies
22. Elevated maternal hemoglobin a in early pregnancy and major congenital anomalies in infants of diabetic mothers
23. Influence of progesterone levels on prostaglandin concentrations in isolated uterine tissue and incubation medium from pseudopregnant rats
24. Whole embryo culture and the study of mammalian embryos during organogenesis
25. Diabetes mellitus affects prostaglandin E2 levels in mouse embryos during neurulation
26. Arachidonic acid prevents hyperglycemia-associated yolk sac damage and embryopathy
27. Dietary polyunsaturated fatty acids prevents malformations in offspring of diabetic rats
28. 2 release from the hypothalamus
29. The eicosanoids and their biochemical mechanisms of action
30. The effect of maternal diabetes on trace element status and fetal development in the rat
31. Teratogenic effects of diabetes mellitus in the rat: Prevention with vitamin E
32. Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro
33. Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture
34. Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-gene expression and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment
35. Hyperglycemic pseudohypoxia and diabetic complications
36. Evidence for embyonic prostaglandin H synthase-catalyzed bioactivation and reactive oxygen species-mediated oxidation of cellular macromolecules in phenytoin and benzo[a]pyrene teratogenesis